Results 61 to 70 of about 40,064,637 (293)

A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes

Genome Medicine, 2021
Background Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown.
Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy J. Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu   +8 more
doaj   +1 more source

First genome-wide association study on anxiety-related behaviours in childhood [PDF]

, 2013
Background: Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects.
Hanscombe, K.B., Oliver S. P. Davis, Plomin, Robert, Maciej Trzaskowski (185577), Hanscombe, Ken B, Doherty, Sophia J, Thomas Price, Haworth, C., Haworth, Claire M. A., Ken B Hanscombe, Robert Plomin (27675), Davis, OS, Haworth, Claire M A, Thalia C Eley, Sophia J. Doherty, Eley, Thalia C, Price, T.S, Hanscombe, KB, Eley Thalia C., Doherty, Sophia J., Eley, Thalia C., Oliver S P Davis, Claire M. A. Haworth (185578), Price, T, Oliver S. P. Davis (185580), Robert Plomin, Doherty, SJ, Maciej Trzaskowski, Claire M A Haworth, Haworth, CM, Thalia C. Eley (397316), Price Thomas, Davis, O.S.P., Haworth Claire M. A., Trzaskowski, Maciej, Claire M. A. Haworth, Davis, Oliver S P, Price, Thomas, Meaburn, Emma L, Thomas Price (397319), Thalia C. Eley, Eley, T.C., Davis Oliver S. P., Trzaskowski, M., Hanscombe Ken B., Docherty, Sophia J., Meaburn Emma L., Meaburn, EL, Davis, Oliver S. P., Emma L. Meaburn, Ken B. Hanscombe (185575), Plomin, R., Sophia J. Doherty (397317), Meaburn, Emma L., Price, Tom S., Plomin Robert, Sophia J Doherty, Doherty, S.J., Trzaskowski, M, Hanscombe, Ken B., Ken B. Hanscombe, Plomin, R, Emma L. Meaburn (397318), Eley, TC, Trzaskowski Maciej, Emma L Meaburn, Doherty Sophia J.   +66 more
core   +1 more source

Prediction of Alzheimer’s Disease-Associated Genes by Integration of GWAS Summary Data and Expression Data

Frontiers in Genetics, 2019
Alzheimer’s disease (AD) is the most common cause of dementia. It is the fifth leading cause of death among elderly people. With high genetic heritability (79%), finding the disease’s causal genes is a crucial step in finding a treatment for AD ...
Sicheng Hao, Rui Wang, Yu Zhang, Hui Zhan   +3 more
doaj   +1 more source

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]

, 2014
Background: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.
Palmer, C. N. A.; id_orcid, H.M. Colhoun, C.N.A. Palmer, Colhoun, H. M., L.A. Donnelly, Liu, Y., Zhou, K., Palmer, C. N A, van Zuydam, N. R., Smith, B. H.; id_orcid, H.A. Deshmukh, N.R. van Zuydam, K. Zhou, A.D. Morris, Donnelly, L. A., Deshmukh, H. A., Morris, A. D., Meng, W., Smith, B. H., Y. Liu, B.H. Smith, W. Meng   +21 more
core   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Identifying susceptibility genes for essential hypertension by transcriptome-wide association study

Biochemistry and Biophysics Reports, 2022
Hypertension is a leading risk factor of cardiovascular disease and mortality in the population worldwide. Recently, hundreds of genomic loci were reported for hypertension by GWAS, however, the most SNPs are located in intergenic regions of genome, where a functional cause is difficult to determine.
Lu-jie Huang, Qiao-xia Zhang, Robert K. Valenzuela, Jia-chen Xu, Fang Yan, Jie Ma   +5 more
openaire   +4 more sources

Identification of asthma-related genes using asthmatic blood eQTLs of Korean patients

BMC Medical Genomics, 2023
Background More than 200 asthma-associated genetic variants have been identified in genome-wide association studies (GWASs). Expression quantitative trait loci (eQTL) data resources can help identify causal genes of the GWAS signals, but it can be ...
Dong Jun Kim, Ji Eun Lim, Hae-Un Jung, Ju Yeon Chung, Eun Ju Baek, Hyein Jung, Shin Young Kwon, Han Kyul Kim, Ji-One Kang, Kyungtaek Park, Sungho Won, Tae-Bum Kim, Bermseok Oh   +12 more
doaj   +1 more source

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Lindgren, Cecilia, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +53 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A transcriptome-wide association study identifies novel susceptibility genes for psoriasis

Human Molecular Genetics, 2021
Abstract Although >80 psoriasis genetic risk loci have been reported through genome-wide association studies (GWASs), the genetic mechanism of psoriasis remains unclear. To identify novel candidate genes associated with psoriasis and reveal the potential effects of genetic factors in the development of psoriasis, we conducted a ...
Dongli, Zhu, Shi, Yao, Hao, Wu, Xin, Ke, Xiaorong, Zhou, Songmei, Geng, Shanshan, Dong, Hao, Chen, Tielin, Yang, Ying, Cheng, Yan, Guo   +10 more
openaire   +2 more sources