Results 31 to 40 of about 41,997,054 (284)

A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk

Frontiers in Genetics, 2022
Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression. While eQTL studies of long RNAs has yielded many potential risk genes, the relationship between PrCa risk ...
Larson, Nicholas B., McDonnell, Shannon K., Fogarty, Zachary, Liu, Yuanhang, French, Amy J., Tillmans, Lori S., Cheville, John C., Wang, Liang, Schaid, Daniel J., Thibodeau, Stephen N.   +9 more
openaire   +3 more sources

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Frontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma, Peilin Li, Li Liu, Shiqiang Cheng, Bolun Cheng, Chu Jun Liang, Sijia Tan, Wenyu Li, Yan Wen, Xiong Guo, Cuiyan Wu   +10 more
doaj   +1 more source

Genome- and Transcriptome-wide Association Studies to Discover Candidate Genes for Diverse Root Phenotypes in Cultivated Rice

Rice, 2023
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control.
Shujun Wei, Ryokei Tanaka, Taiji Kawakatsu, Shota Teramoto, Nobuhiro Tanaka, Matthew Shenton, Yusaku Uga, Shiori Yabe   +7 more
doaj   +1 more source

Assigning function to genome wide association study variants associated with complex gastrointestinal disease [PDF]

, 2009
PhDThe genome‐wide association study era has identified numerous loci associated with many common polygenic diseases. The next challenge is to identify the functional consequences of these variants and elicit how they impact on disease risk.
Heap, Graham Alastair Richard
core   +2 more sources

Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease [PDF]

, 2022
Genetic correlations and an increased incidence of psychiatric disorders in inflammatory-bowel disease have been reported, but shared molecular mechanisms are unknown. We performed cross-tissue and multiple-gene conditioned transcriptome-wide association
Borisov, Oleg V., Maj, Carlo, Krawitz, Peter, Folseraas, Trine,, Degenhardt, Franziska,, Karlsen, Tom Hemming,, Schramm, Christoph, Steiert, Tim Alexander, Karlsen, Tom Hemming, Hoffmann, Per,, Wacker, Eike Matthias, Borisov, Oleg, Franke, Andre,, Jorgensen, Isabella Friis, Bej, Saptarshi, Schreiber, Stefan, Borisov, Oleg,, Jørgensen, Isabella Friis, Schramm, Christoph,, Schreiber, Stefan,, Brunak, Søren, Nöthen, Markus,, Ellinghaus, David,, Wolkenhauer, Olaf, Juzėnas, Simonas,, Jørgensen, Isabella Friis,, Banasik, Karina,, Wolkenhauer, Olaf,, Uellendahl-Werth, Florian, Banasik, Karina, Franke, Andre, Ellinghaus, David, Noethen, Markus, Uellendahl-Werth, Florian,, Degenhardt, Franziska, Maj, Carlo,, Steiert, Tim Alexander,, Juzenas, Simonas, Folseraas, Trine, Nöthen, Markus, Hoffmann, Per, Wacker, Eike Matthias,, Krawitz, Peter,, Nöthen, Markus M., Bej, Saptarshi,, Brunak, Søren,, Uellendahl-Werth, Florian ; Maj, Carlo ; Borisov, Oleg ; Juzenas, Simonas ; Wacker, Eike Matthias ; Jørgensen, Isabella Friis ; Steiert, Tim Alexander ; Bej, Saptarshi ; Krawitz, Peter ; Hoffmann, Per ; Schramm, Christoph ; Wolkenhauer, Olaf ; Banasik, Karina ; Brunak, Søren ; Schreiber, Stefan ; Karlsen, Tom Hemming ; Degenhardt, Franziska ; Nöthen, Markus ; Franke, Andre ; Folseraas, Trine ; Ellinghaus, David, Trine Folseraas, Franziska Degenhardt, Karina Banasik, Christoph Schramm, Peter Krawitz, Eike Matthias Wacker, David Ellinghaus, Søren Brunak, Stefan Schreiber, Markus Nöthen, Tim Alexander Steiert, Olaf Wolkenhauer, Per Hoffmann, Tom Hemming Karlsen, Oleg Borisov, Florian Uellendahl-Werth, Andre Franke, Saptarshi Bej, Isabella Friis Jørgensen, Simonas Juzenas, Carlo Maj   +67 more
core   +2 more sources

Identifying and Exploring the Candidate Susceptibility Genes of Cirrhosis Using the Multi-Tissue Transcriptome-Wide Association Study

Frontiers in Genetics, 2022
Objective: We identify and explore the candidate susceptibility genes for cirrhosis and their underlying biological mechanism.Methods: We downloaded the genome-wide association studies summary data of 901 cirrhosis cases and 451,363 controls and ...
Xiao-Bo Zhu, Yu-Qing Hou, Xiang-Yu Ye, Yi-Xin Zou, Xue-Shan Xia, Sheng Yang, Peng Huang, Rong-Bin Yu   +7 more
doaj   +1 more source

Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma. [PDF]

Cancer Epidemiol Biomarkers Prev
Abstract Background: Hepatoblastoma (HB) is a rare embryonal liver tumor, with an increasing global incidence that underscores the need to understand its genetic etiology. Methods: Utilizing the ancestry-matched ...
Xie T, Sorenson JC, Spector LG, Pankratz N, Huang RS, Hiyama E, Poynter JN, Tomlinson GE, Armengol C, Kappler R, Scheurer ME, Roman E, Castellano A, Grotzer MA, Ziegler DS, Basu S, Marcotte EL, Yang T.   +17 more
europepmc   +3 more sources

Multivariate adaptive shrinkage improves cross-population transcriptome prediction for transcriptome-wide association studies in underrepresented populations

, 2023
This Zenodo file collection contains transcriptome prediction models built for PrediXcan, as well as concatenated raw results from SPrediXcan. Files belong to the scientific research paper: "Multivariate adaptive shrinkage improves cross-population ...
Liu, Yongmei, Rich, Stephen S, Durda, Peter, Mikhaylova, Anna V, Gignoux, Chris, Papanicolaou, George, Nguyen, Chris, Im, Hae Kyung, Rotter, Jerome I, Manichaikul, Ani, Taylor, Kent D, Wheeler, Heather E, Hu, Xiaowei, Cho, Michael H, Araujo, Daniel S, NHLBI TOPMed Consortium, Ardlie, Kristin   +16 more
core   +1 more source

Transcriptome-wide association studies: opportunities and challenges [PDF]

, 2017
Transcriptome-wide association studies (TWAS) integrate GWAS and gene expression datasets to find gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes, using simulations and case studies of literature-curated candidate causal genes for schizophrenia, LDL cholesterol and Crohn’s ...
Wainberg, Michael, Sinnott-Armstrong, Nasa, Mancuso, Nicholas, Barbeira, Alvaro N., Knowles, David A, Golan, David, Ermel, Raili, Ruusalepp, Arno, Quertermous, Thomas, Hao, Ke, Björkegren, Johan LM, Kyung Im, Hae, Pasaniuc, Bogdan, Rivas, Manuel A, Kundaje, Anshul   +14 more
openaire   +1 more source

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

Human Genomics, 2019
Background While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and
Molly Went, Ben Kinnersley, Amit Sud, David C. Johnson, Niels Weinhold, Asta Försti, Mark van Duin, Giulia Orlando, Jonathan S. Mitchell, Rowan Kuiper, Brian A. Walker, Walter M. Gregory, Per Hoffmann, Graham H. Jackson, Markus M. Nöthen, Miguel Inacio da Silva Filho, Hauke Thomsen, Annemiek Broyl, Faith E. Davies, Unnur Thorsteinsdottir, Markus Hansson, Martin Kaiser, Pieter Sonneveld, Hartmut Goldschmidt, Kari Stefansson, Kari Hemminki, Björn Nilsson, Gareth J. Morgan, Richard S. Houlston   +28 more
doaj   +1 more source