Transcriptome-wide association study identifies genes associated with bladder cancer risk. [PDF]
Sci RepAbstractGenome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear. To extend GWAS findings, we conducted a transcriptome-wide association study (TWAS) using PrediXcan to predict gene expression levels in whole blood using genome ...
Li S, Gui J, Karagas MR, Passarelli MN.
europepmc +6 more sources
Transcriptome-wide association study identified candidate genes associated with gut microbiota [PDF]
Gut Pathogens, 2021 Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.
Chuyu Pan +12 more
doaj +3 more sources
MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies [PDF]
PLOS Genetics, 2020 Traditional predictive models for transcriptome-wide association studies (TWAS) consider only single nucleotide polymorphisms (SNPs) local to genes of interest and perform parameter shrinkage with a regularization process. These approaches ignore the effect of distal-SNPs or other molecular effects underlying the SNP-gene association.
Arjun Bhattacharya +2 more
openaire +8 more sources
Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis [PDF]
Arthritis Research & Therapy, 2021 Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu +11 more
doaj +3 more sources
A Transcriptome‐Wide Association Study Identifies Candidate Susceptibility Loci and Genes for Lung Cancer Risk [PDF]
Cancer MedicineBackground Genome‐wide association studies (GWAS) have identified over 80 susceptibility loci for lung cancer risk. However, the genes underlying these associations remain largely unknown. Methods We conducted a large transcriptome‐wide association study
Tianying Zhao +13 more
doaj +2 more sources
Multi-tissue transcriptome-wide association study identifies novel candidate genes and pleiotropy effects across four abdominal hernia subtypes [PDF]
HGG AdvancesSummary: Abdominal hernias are caused by the protrusion of an organ or tissue through a weakened abdominal wall. Genome-wide association studies (GWASs) have identified 81 genetic susceptibility loci for different hernia subtypes, with 26 loci associated
Dima L. Chaar +10 more
doaj +2 more sources
Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s disease [PDF]
Genome Medicine, 2020 Alzheimer’s disease (AD) is an incurable neurodegenerative disease currently affecting 1.75% of the US population, with projected growth to 3.46% by 2050.
Jake Gockley +11 more
semanticscholar +2 more sources
Multi-ethnic transcriptome-wide association study of prostate cancer.
PLoS ONE, 2020 The genetic risk for prostate cancer has been governed by a few rare variants with high penetrance and over 150 commonly occurring variants with lower impact on risk; however, most of these variants have been identified in studies containing exclusively ...
Peter N Fiorica +4 more
doaj +4 more sources
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions [PDF]
Nature Communications, 2018 Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown.
Nicholas Mancuso +74 more
semanticscholar +2 more sources
Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes [PDF]
Human Genomics, 2019 Background While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and
Molly Went +28 more
doaj +5 more sources