Results 231 to 240 of about 181,971 (294)

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

Advanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue   +8 more
wiley   +1 more source

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for frailty. [PDF]

Front Genet
Lin D, Wu S, Li W, Ye P, Pan X, Zheng T, Gao F.   +6 more
europepmc   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

Transcriptome-Wide Association Study Reveals New Molecular Interactions Associated with Melanoma Pathogenesis. [PDF]

Cancers (Basel)
Saad MN, Hamed M.
europepmc   +1 more source

Additional file 9: Table S7. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis

, 2017
Tatiana Maroilley, Gaëtan Lemonnier, Jérôme Lecardonnel, D. EsquerrĂŠ, Yuliaxis Ramayo‐Caldas, Marie-José Mercat, Claire Rogel Gaillard, J. EstellĂŠ   +7 more
openalex   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine. [PDF]

J Headache Pain
Gui J, Yang X, Tan C, Wang L, Meng L, Han Z, Liu J, Jiang L.   +7 more
europepmc   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

A transcriptome-wide association study identified susceptibility genes for hepatocellular carcinoma in East Asia. [PDF]

Gastroenterol Rep (Oxf)
Zhang J, Zhang Q, Hu W, Liang Y, Jiang D, Chen H.   +5 more
europepmc   +1 more source