Results 21 to 30 of about 181,971 (294)

2D association and integrative omics analysis in rice provides systems biology view in trait analysis. [PDF]

, 2018
The interactions among genes and between genes and environment contribute significantly to the phenotypic variation of complex traits and may be possible explanations for missing heritability.
Dai, Xinbin, Xu, Shizhong, Zhang, Wenchao, Zhao, Patrick X   +3 more
core   +2 more sources

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source

Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia. [PDF]

, 2016
Autism (AUT), schizophrenia (SCZ) and bipolar disorder (BPD) are three highly heritable neuropsychiatric conditions. Clinical similarities and genetic overlap between the three disorders have been reported; however, the causes and the downstream effects ...
Arking, DE, Ellis, SE, Panitch, R, West, AB   +3 more
core   +1 more source

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

Human Genomics, 2019
Background While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and
Molly Went, Ben Kinnersley, Amit Sud, David C. Johnson, Niels Weinhold, Asta Försti, Mark van Duin, Giulia Orlando, Jonathan S. Mitchell, Rowan Kuiper, Brian A. Walker, Walter M. Gregory, Per Hoffmann, Graham H. Jackson, Markus M. Nöthen, Miguel Inacio da Silva Filho, Hauke Thomsen, Annemiek Broyl, Faith E. Davies, Unnur Thorsteinsdottir, Markus Hansson, Martin Kaiser, Pieter Sonneveld, Hartmut Goldschmidt, Kari Stefansson, Kari Hemminki, Björn Nilsson, Gareth J. Morgan, Richard S. Houlston   +28 more
doaj   +1 more source

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

Cancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han   +5 more
doaj   +1 more source

Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs. [PDF]

, 2018
Approximately 1500 RNA-binding proteins (RBPs) profoundly impact mammalian cellular function by controlling distinct sets of transcripts, often using sequence-specific binding to 3' untranslated regions (UTRs) to regulate mRNA stability and translation ...
Estep, Jason A, Karginov, Fedor V, Li, Yahui, Nguyen, Daniel K, Sternburg, Erin L   +4 more
core   +3 more sources

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

Frontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng, Mengnan Lu, Lin Liu, Ke Xu, Peng Xu   +4 more
doaj   +1 more source

Integrative analysis of transcriptome-wide association study and gene expression profiling identifies candidate genes associated with stroke [PDF]

PeerJ, 2019
Background Stroke is a major public health burden worldwide. Although genetic variation is known to play a role in the pathogenesis of stroke, the specific pathogenic mechanisms are still unclear.
Jian Yang, Bin Yan, Yajuan Fan, Lihong Yang, Binbin Zhao, Xiaoyan He, Qingyan Ma, Wei Wang, Ling Bai, Feng Zhang, Xiancang Ma   +10 more
doaj   +2 more sources

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights [PDF]

, 2018
Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 ...
Crawford, Gregory E, Finucane, Hilary K, Geschwind, Daniel H, Gusev, Alexander, Katsanis, Nicholas, Kousi, Maria, Mancuso, Nicholas, McCarroll, Steven, Neale, Benjamin M, O'Donovan, Michael C, Ophoff, Roel A, Pasaniuc, Bogdan, Price, Alkes L, Reshef, Yakir, Safi, Alexias, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Song, Lingyun, Sullivan, Patrick F, Won, Hyejung   +18 more
core   +2 more sources