Review of precision cancer medicine: Evolution of the treatment paradigm. [PDF]
, 2020 In recent years, biotechnological breakthroughs have led to identification of complex and unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling, immune markers, and proteomic and RNA analyses are used to identify ...
Fountzilas, Elena +3 more
core +1 more source
Nutrigenomics and immune function in fish : new insights from omics technologies [PDF]
, 2017 This study was funded by BBSRC grant BB/M026604/1.Peer reviewedPublisher ...
Krol, Elzbieta, Martin, Samuel A. M.
core +1 more source
Pathway analysis and transcriptomics improve protein identification by shotgun proteomics from samples comprising small number of cells - a benchmarking study [PDF]
, 2014 BACKGROUND: Proteomics research is enabled with the high-throughput technologies, but our ability to identify expressed proteome is limited in small samples. The coverage and consistency of proteome expression are critical problems in proteomics.
Brusic, Vladimir +8 more
core +5 more sources
Making open data work for plant scientists [PDF]
, 2013 Despite the clear demand for open data sharing, its implementation within plant science is still limited. This is, at least in part, because open data-sharing raises several unanswered questions and challenges to current research practices.
Alsheikh-Ali +24 more
core +1 more source
Maternal recognition of pregnancy in the horse : are MicroRNAs the secret messengers? [PDF]
, 2020 The signal for maternal recognition of pregnancy (MRP) has still not been identified in the horse. High-throughput molecular biology at the embryo-maternal interface has substantially contributed to the knowledge on pathways affected during MRP, but an ...
Deforce, Dieter +11 more
core +2 more sources
Single-cell transcriptomics : a high-resolution avenue for plant functional genomics [PDF]
, 2019 Plant function is the result of the concerted action of single cells in different tissues. Advances in RNA-seq technologies and tissue processing allow us now to capture transcriptional changes at single-cell resolution.
Finch, Jessica A. +5 more
core +1 more source
Complex Systems Science: Dreams of Universality, Reality of Interdisciplinarity [PDF]
, 2012 Using a large database (~ 215 000 records) of relevant articles, we empirically study the "complex systems" field and its claims to find universal principles applying to systems in general. The study of references shared by the papers allows us to obtain
Bastian M. +9 more
core +4 more sources
2D association and integrative omics analysis in rice provides systems biology view in trait analysis. [PDF]
, 2018 The interactions among genes and between genes and environment contribute significantly to the phenotypic variation of complex traits and may be possible explanations for missing heritability.
Dai, Xinbin +3 more
core +2 more sources
Cost effective, experimentally robust differential-expression analysis for human/mammalian, pathogen and dual-species transcriptomics. [PDF]
, 2020 As sequencing read length has increased, researchers have quickly adopted longer reads for their experiments. Here, we examine 14 pathogen or host-pathogen differential gene expression data sets to assess whether using longer reads is warranted.
Bruno, Vincent M +9 more
core +2 more sources
Using transcriptomics to guide lead optimization in drug discovery projects : lessons learned from the QSTAR project [PDF]
, 2015 The pharmaceutical industry is faced with steadily declining R&D efficiency which results in fewer drugs reaching the market despite increased investment.
Bender, Andreas +10 more
core +2 more sources