Results 21 to 30 of about 248,325 (264)

Metatranscriptomics reveals a differential temperature effect on the structural and functional organization of the anaerobic food web in rice field soil

open access: yesMicrobiome, 2018
Background The expected increase in global surface temperature due to climate change may have a tremendous effect on the structure and function of the anaerobic food web in flooded rice field soil.
Jingjing Peng   +4 more
doaj   +1 more source

Methylocystis sp. Strain SC2 Acclimatizes to Increasing NH4+ Levels by a Precise Rebalancing of Enzymes and Osmolyte Composition

open access: yesmSystems, 2022
A high NH4+ load is known to inhibit bacterial methane oxidation. This is due to a competition between CH4 and NH3 for the active site of particulate methane monooxygenase (pMMO), which converts CH4 to CH3OH.
Kangli Guo   +4 more
doaj   +1 more source

Quantitative RNA-seq Analysis Unveils Osmotic and Thermal Adaptation Mechanisms Relevant for Ectoine Production in Chromohalobacter salexigens [PDF]

open access: yes, 2018
Quantitative RNA sequencing (RNA-seq) and the complementary phenotypic assays were implemented to investigate the transcriptional responses of Chromohalobacter salexigens to osmotic and heat stress.
Carmen Vargas   +6 more
core   +2 more sources

Modeling population size independent tissue epigenomes by ChIL‐seq with single thin sections

open access: yesMolecular Systems Biology, 2021
Recent advances in genome‐wide technologies have enabled analyses using small cell numbers of even single cells. However, obtaining tissue epigenomes with cell‐type resolution from large organs and tissues still remains challenging, especially when the ...
Kazumitsu Maehara   +11 more
doaj   +1 more source

Photo-isolation chemistry for high-resolution and deep spatial transcriptome with mouse tissue sections

open access: yesSTAR Protocols, 2022
Summary: Photo-isolation chemistry (PIC) enables isolation of transcriptome information from locally defined areas by photo-irradiation. Here, we present an optimized PIC protocol for formalin-fixed frozen and paraffin mouse sections and fresh-frozen ...
Mizuki Honda   +6 more
doaj   +1 more source

The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target

open access: yesViruses, 2023
The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19.
Teresa Santos-Mendoza
doaj   +1 more source

Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli [PDF]

open access: yes, 2017
Escherichia coli that are capable of causing human disease are often classified into pathogenic variants (pathovars) based on their virulence gene content. However, disease-associated hybrid E.
Daugherty, Sean C   +6 more
core   +2 more sources

Transcriptomics technologies

open access: yesPLOS Computational Biology, 2017
© 2017 Lowe et al. Transcriptomics technologies are the techniques used to study an organism’s transcriptome, the sum of all of its RNA transcripts. The information content of an organism is recorded in the DNA of its genome and expressed through transcription.
Rohan Lowe   +4 more
openaire   +6 more sources

Rare Variants in Neurodegeneration Associated Genes Revealed by Targeted Panel Sequencing in a German ALS Cohort

open access: yesFrontiers in Molecular Neuroscience, 2016
Amyotrophic lateral sclerosis (ALS) is a progressive fatal multisystemic neurodegenerative disorder caused by preferential degeneration of upper and lower motor neurons.
Stefanie Krüger   +15 more
doaj   +1 more source

Inferring spatial and signaling relationships between cells from single cell transcriptomic data. [PDF]

open access: yes, 2020
Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however, crucial spatial information is often lost. We present SpaOTsc, a method relying on structured optimal transport to recover spatial properties of scRNA-seq data by ...
Cang, Zixuan, Nie, Qing
core  

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