Results 21 to 30 of about 398,969 (379)

Cost effective, experimentally robust differential-expression analysis for human/mammalian, pathogen and dual-species transcriptomics. [PDF]

, 2020
As sequencing read length has increased, researchers have quickly adopted longer reads for their experiments. Here, we examine 14 pathogen or host-pathogen differential gene expression data sets to assess whether using longer reads is warranted.
Bruno, Vincent M, Chung, Matthew, Dunning Hotopp, Julie C, Filler, Scott G, Fraser, Claire M, Mahurkar, Anup, Mattick, John, McCracken, Carrie, Rasko, David A, Shetty, Amol C   +9 more
core   +2 more sources

Advances in spatial transcriptomics and related data analysis strategies

Journal of Translational Medicine, 2023
Spatial transcriptomics technologies developed in recent years can provide various information including tissue heterogeneity, which is fundamental in biological and medical research, and have been making significant breakthroughs.
Jun Du, Yu-chen Yang, Zhi-Jie An, Ming-hui Zhang, Xue-Hang Fu, Zoufang Huang, Ye Yuan, Jian Hou   +7 more
semanticscholar   +1 more source

Molecular tumor analysis and liquid biopsy: a feasibility investigation analyzing circulating tumor DNA in patients with central nervous system lymphomas

BMC Cancer, 2019
Background Central nervous system lymphomas (CNSL) is a devastating disease. Currently, a confirmatory biopsy is required prior to treatment. Objective Our investigation aims to prove the feasibility of a minimally-invasive diagnostic approach for the ...
Anne-Katrin Hickmann, Maximilian Frick, Dirk Hadaschik, Florian Battke, Markus Bittl, Oliver Ganslandt, Saskia Biskup, Dennis Döcker   +7 more
doaj   +1 more source

NF-κB activity during pancreas development regulates adult β-cell mass by modulating neonatal β-cell proliferation and apoptosis

Cell Death Discovery, 2021
NF-κB is a well-characterized transcription factor, widely known for its roles in inflammation and immune responses, as well as in control of cell division and apoptosis. However, its function in β-cells is still being debated, as it appears to depend on
Dror Sever, Anat Hershko-Moshe, Rohit Srivastava, Roy Eldor, Daniel Hibsher, Hadas Keren-Shaul, Ido Amit, Federico Bertuzzi, Lars Krogvold, Knut Dahl-Jørgensen, Iddo Z. Ben-Dov, Limor Landsman, Danielle Melloul   +12 more
doaj   +1 more source

Tricks to translating TB transcriptomics. [PDF]

, 2015
Transcriptomics and other high-throughput methods are increasingly applied to questions relating to tuberculosis (TB) pathogenesis. Whole blood transcriptomics has repeatedly been applied to define correlates of TB risk and has produced new insight into ...
Coussens, AK, Deffur, A, Wilkinson, RJ
core   +1 more source

Morpho-molecular identification and first report of Fusarium equiseti in causing chilli wilt from Kashmir (Northern Himalayas)

Scientific Reports, 2021
Chilli (Capsicum annuum L.) is one of the most significant vegetable and spice crop. Wilt caused by Fusarium Sp. has emerged as a serious problem in chilli production.
Ammarah Hami, Rovidha S. Rasool, Nisar A. Khan, Sheikh Mansoor, Mudasir A. Mir, Nazeer Ahmed, Khalid Z. Masoodi   +6 more
doaj   +1 more source

Complex Systems Science: Dreams of Universality, Reality of Interdisciplinarity [PDF]

, 2012
Using a large database (~ 215 000 records) of relevant articles, we empirically study the "complex systems" field and its claims to find universal principles applying to systems in general. The study of references shared by the papers allows us to obtain
Bastian M., Börner K., Fox–Keller E., Galison P., Kessler M.M., Leydesdorff L., Nicolis G., Press W.H., Venturini T., Von Bertalanffy L.   +9 more
core   +4 more sources

Probabilistic embedding, clustering, and alignment for integrating spatial transcriptomics data with PRECAST

bioRxiv, 2023
Spatially resolved transcriptomics involves a set of emerging technologies that enable the transcriptomic profiling of tissues with the physical location of expressions. Although a variety of methods have been developed for data integration, most of them
Wei Liu, Xu Liao, Ziye Luo, Yi Yang, M. Lau, Yuling Jiao, Xingjie Shi, Weiwei Zhai, Hongkai Ji, J. Yeong, Jin Liu   +10 more
semanticscholar   +1 more source

The custom transcriptome [PDF]

Science, 2020
Unraveling tissue-specific ...
openaire   +3 more sources

Tumor mutation burden and circulating tumor DNA in combined CTLA-4 and PD-1 antibody therapy in metastatic melanoma – results of a prospective biomarker study

Journal for ImmunoTherapy of Cancer, 2019
Background Metastasized or unresectable melanoma has been the first malignant tumor to be successfully treated with checkpoint inhibitors. Nevertheless, about 40–50% of the patients do not respond to these treatments and severe side effects are observed ...
Andrea Forschner, Florian Battke, Dirk Hadaschik, Martin Schulze, Stephanie Weißgraeber, Chung-Ting Han, Maria Kopp, Maximilian Frick, Bernhard Klumpp, Nicola Tietze, Teresa Amaral, Peter Martus, Tobias Sinnberg, Thomas Eigentler, Ulrike Keim, Claus Garbe, Dennis Döcker, Saskia Biskup   +17 more
doaj   +1 more source