Results 161 to 170 of about 37,961 (284)
A Biomimetic Micro‐Nano System Maximizing ‘Active Transport and Retention’ Effect in Solid Tumors
Small, Volume 22, Issue 25, 4 May 2026.The Active Transport and Retention (ATR) strategy is realized using a biomimetic micro‐nano system (PG@BAM‐LRC), achieving superior tumor accumulation and efficacy in low‐EPR pancreatic tumors. Platelet (PG)‐derived microcarriers enable tumor‐homing and MMP‐9‐responsive release of nanoliposomes (LRC), while berbamine (BAM) promotes transendothelial ...
Kaiyun Yang +4 more
wiley +1 more source
Aged Gut Microbiota Induces Mucosal Transcriptional Dysregulation, Impairing Immune Surveillance
Aging Cell, Volume 25, Issue 5, May 2026.Aging impaired intestinal mucosal immune homeostasis by altering the epithelial barrier, lamina propria immune cells, follicle‐associated epithelium, and gut microbiota. These changes, particularly the accumulation of pro‐inflammatory bacteria in the gut microbiota, are closely associated with dysregulation of follicle‐associated epithelium gene ...
Fang Wu +10 more
wiley +1 more source
Method of establishing breast cancer brain metastases affects brain uptake and efficacy of targeted, therapeutic nanoparticles [PDF]
, 2019 HER2‐targeted therapies effectively control systemic disease, but their efficacy against brain metastases is hindered by their low penetration of the blood‐brain and blood‐tumor barriers (BBB and BTB).
Davis, Mark E., Wyatt, Emily A.
core
Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik +3 more
wiley +1 more source
Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley +1 more source
HeliyonAims: Previous studies have reported that focused ultrasound (FUS) helps modulate the blood-brain barrier (BBB). These studies have generally used the paracellular pathway owing to tight junction proteins (TJPs) regulation.
Younghee Seo +7 more
doaj +1 more source
Normal cochlear lateral wall permeability to fluorescent macromolecules [PDF]
, 2013 Damage to the stria vascularis resulting in leakage of macromolecules from the capillaries has been indicated in research as undermining the endocochlear potential.
Henson, Veronica E
core +1 more source
Transcytosis of T4 Bacteriophage Through Intestinal Cells Enhances Its Immune Activation
VirusesInteractions between bacteriophages with mammalian immune cells are of great interest and most phages possess at least one molecular pattern (nucleic acid, sugar residue, or protein structure) that is recognizable to the immune system through pathogen ...
Amanda Carroll-Portillo +5 more
doaj +1 more source
BiomoleculesThe tympanic membrane forms an impenetrable barrier between the ear canal and the air-filled middle ear, protecting it from fluid, pathogens, and foreign material entry.
Arwa Kurabi +4 more
doaj +1 more source