Physiological and anatomical determinants of placental drug transfer
The Journal of Physiology, EarlyView.Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
wiley +1 more source
Advanced ScienceHydrogels are prevailing drug delivery depots to improve antitumor efficacy and reduce systemic toxicity. However, the application of conventional free drug‐loaded hydrogel is hindered by poor drug penetration in solid tumors.
Rong Liu +6 more
doaj +1 more source
Painless Biosensing for Non‐Invasive Health Monitoring: Advances, Platforms and Future Directions
Electrochemical Science Advances, Volume 6, Issue 5, October 2026.ABSTRACT Non‐invasive biosensing has expanded blood‐based diagnostics into a growing set of accessible peripheral biofluids, yet most existing reviews remain confined to sweat, tears, saliva and urine, and treat the underlying literature descriptively rather than critically.
Ayub Alam +10 more
wiley +1 more source
Ferritin‐Based Nanomotors for Deep Glioblastoma Penetration and Enhanced Drug Delivery
Macromolecular Bioscience, Volume 26, Issue 10, October 2026.We report an oxygen‐propelled nanomotor composed of human heavy‐chain ferritin nanocage (HFn) and catalytic CeO2 nanoparticles to enhance tumor penetration and therapeutic efficacy. HFn efficiently traversed the blood‐brain barrier (BBB), while oxygen generated by CeO2‐catalyzed H2O2 decomposition propelled the nanomotor deep into tumor spheroids ...
Jun Ma +4 more
wiley +1 more source
Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment
Biology of the Cell, Volume 118, Issue 10, October 2026.Functional alliances of stromal, innate and adaptive immune cells in EV immunity in the lymph node. EV reflect the phenotype of their mother cell and cluster material from their surroundings. In the lymph node, EV preserve valuable context information between multiple cellular effectors to coordinate immunity in adaption to change.
Alicia Charrier +4 more
wiley +1 more source
Transcytosis of LDL across arterial endothelium: mechanisms and therapeutic targets
Transport of LDL (low-density lipoprotein) from plasma to arterial intima is thought to be rate limiting in the development of atherosclerosis. Its variation likely determines where lesions develop within arteries and might account for some of the ...
de Liedekerke Beaufort, Gaetan +2 more
core +1 more source
Impact of ASO conjugation and receptor binding affinity on intracellular transport of mono- and bispecific TfR- and CD98-Brainshuttle<sup>TM</sup> variants. [PDF]
MAbsSela T +13 more
europepmc +1 more source
Fine-tuning of liposome integrity for differentiated transcytosis and enhanced antitumor efficacy
Transcytosis-inducing nanomedicines have been developed to improve tumor extravasation. However, the fate during transcytosis across multicell layers and the structural integrity of the nanomedicines before reaching tumor cells could impact antitumor ...
Wu, Chenchen +7 more
core +1 more source
Laser interstitial thermal therapy enhances bidirectional blood-brain barrier permeability in glioblastoma. [PDF]
Neuro OncolCleary RT +11 more
europepmc +1 more source
Multifunctional Hybrid Nanomedicines for Neurodegenerative Diseases: A Paradigm Shift from Rational Design to Clinical Translation. [PDF]
Int J NanomedicineWu Y +6 more
europepmc +1 more source