Results 141 to 150 of about 37,961 (284)

Human placental exposure to pollutant nanoparticles: uptake, translocation and functional impact

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to pollutant nanoparticles has been increasingly investigated due to concerns about their potential effects on placental function and pregnancy outcomes. Maternal inhalation of pollutant nanoparticles can result in a pro‐inflammatory response; particles can also translocate across the alveolus epithelial barrier
Katherine L. Bethell, Andrew C. Povey, Edward D. Johnstone, Peter T. Ruane   +3 more
wiley   +1 more source

Exploring Zika Virus Impact on Endothelial Permeability: Insights into Transcytosis Mechanisms and Vascular Leakage

Viruses
Treating brain disease is challenging, and the Zika virus (ZIKV) presents a unique obstacle due to its neuroinvasive nature. In this review, we discuss the immunopathogenesis of ZIKV and explore how the virus interacts with the body’s immune responses ...
Dama Faniriantsoa Henrio Marcellin, Jufang Huang   +1 more
doaj   +1 more source

Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge. [PDF]

, 2015
Although IgA is the most abundantly produced immunoglobulin in humans, its role in preventing HIV-1 acquisition, which occurs mostly via mucosal routes, remains unclear.
Agatic, Gloria, Bachler, Barbara C, Corti, Davide, Forthal, Donald N, Gupta, Sandeep, Heeney, Jonathan L, Hemashettar, Girish, Lakhashe, Samir K, Lanzavecchia, Antonio, Ruprecht, Ruth M, Sattentau, Quentin J, Sholukh, Anton M, Thorat, Swati, Villinger, Francois, Vyas, Hemant K, Watkins, Jennifer D, Weiss, Robin A, Zhou, Mingkui   +17 more
core   +2 more sources

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Modulation of Paracellular Permeability in SARS-CoV-2 Blood-to-Brain Transcytosis

Viruses
SARS-CoV-2 primarily infects the lungs via the ACE2 receptor but also other organs including the kidneys, the gastrointestinal tract, the heart, and the skin.
Taylor E. Martinez, Karthick Mayilsamy, Shyam S. Mohapatra, Subhra Mohapatra   +3 more
doaj   +1 more source

Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection

Viruses, 2018
The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage.
Chanettee Chanthick, Aroonroong Suttitheptumrong, Nantapon Rawarak, Sa-nga Pattanakitsakul   +3 more
doaj   +1 more source

PPARγ agonist-loaded PLGA -PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies [PDF]

, 2018
Objective: The first aim of this study was to develop a nanocarrier that could transport the peroxisome proliferator-activated receptor agonist, pioglitazone (PGZ) across brain endothelium and examine the mechanism of nanoparticle transcytosis.
Benito, Pol Andres, Calpena, Ana Cristina, Espina, Marta, Ferrer, Isidre, Garcia, Maria Luisa, Gromnicova, Radka, Male, David, Roig-Carles, David, Romero, Ignacio A., Silva-Abreu, Marcelle   +9 more
core   +1 more source

Human brain pericytes protect the blood–brain barrier from triple‐negative breast cancer cells while promoting tumor aggressiveness

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract The majority of breast cancer‐related deaths result from metastatic progression, especially brain metastasis, associated with the poorest prognosis. Patients with triple‐negative breast cancer (TNBC) are particularly prone to developing brain metastases.
Eloise Happernegg, Marine Carroué, Julien Cicero, Lucie Dehouck, Fumitaka Shimizu, Takashi Kanda, Chann Lagadec, Fabien Gosselet, Xuefen Le Bourhis, Maxime Culot, Robert‐Alain Toillon, Caroline Mysiorek   +11 more
wiley   +1 more source

TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells [PDF]

, 2014
Rab11a is a key modulator of vesicular trafficking processes, but there is limited information about the guanine nucleotide-exchange factors and GTPase-activating proteins (GAPs) that regulate its GTP-GDP cycle. We observed that in the presence of Mg(2+)
Apodaca, Gerard, Clayton, Dennis R., Fukuda, Mitsunori, Gallo, Luciana I., Jiang, Yu, Li, Min, Liao, Yong, Liu, Yong-Jian, Ruiz, Wily G., Yin, Xiao-Ming   +9 more
core   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source