Transdermal Permeation of Drugs in Various Animal Species. [PDF]
Pharmaceutics, 2017 Excised human skin is utilized for in vitro permeation experiments to evaluate the safety and effect of topically-applied drugs by measuring its skin permeation and concentration. However, ethical considerations are the major problem for using human skin to evaluate percutaneous absorption.
Todo H.
europepmc +8 more sources
Mechanism investigation of ethosomes transdermal permeation. [PDF]
Int J Pharm X, 2019 Ethosomes are widely used to promote transdermal permeation of both lipophilic and hydrophilic drugs, but the mechanism of interaction between the ethosomes and the skin remains unclear. In this work, it was exploded with several technologies and facilities.
Niu XQ +10 more
europepmc +4 more sources
Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers. [PDF]
Sci Rep, 2022 Kopečná M +3 more
europepmc +3 more sources
Investigation of transdermal permeation of atorvastatinloaded microemulsions
Tropical Journal of Pharmaceutical Research, 2022 Purpose: To develop microemulsions containing atorvastatin for transdermal application, which will improve the bioavailability and reduce the side effects associated with the oral administration of atorvastatin.Methods: Atorvastatin-loaded microemulsions (MEs) were developed using tween 80 as a nonionic surfactant, isopropyl myristate, polyethylene ...
Jamal Alyoussef Alkrad +3 more
openalex +4 more sources
Fabrication of Ethosomes Containing Tocopherol Acetate to Enhance Transdermal Permeation: In Vitro and Ex Vivo Characterizations. [PDF]
Gels, 2022 Akhtar N +6 more
europepmc +3 more sources
Recent developments in skin mimic systems to predict transdermal permeation [PDF]
Current Pharmaceutical Design, 2015 In recent years there has been a drive to create experimental techniques that can facilitate the accurate and precise prediction of transdermal permeation without the use of in vivo studies.
Waters, Laura J.
core +4 more sources
Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients. [PDF]
AAPS PharmSciTech, 2020 Davis DA +6 more
europepmc +3 more sources
Effect of microneedles on transdermal permeation enhancement of amlodipine [PDF]
Drug Delivery and Translational Research, 2017 The present study aimed to investigate the effect of microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of amlodipine (AMLO). Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PM) of 0.6 mm length were employed. In the
Buchi N. Nalluri +6 more
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Predicting Skin Permeability by means of Computational Approaches : Reliability and Caveats in Pharmaceutical Studies [PDF]
, 2019 © 2019 American Chemical Society.The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters.
Almerico, Anna Maria +5 more
core +2 more sources
Transdermal evaluation of caffeine in different formulations and excipients [PDF]
, 2013 Background: The stratum corneum(SC) forms adifficultphysical barrier fordrugs to pass through the skin. Several strategieswere developed to overcome this barrier.Optimization of topical drug formulations by selected excipients may facilitate the ...
Boonen, Jente +7 more
core +2 more sources