Results 1 to 10 of about 50 (50)

Effect of Ultrasound on Transdermal Permeation of Diclofenac [PDF]

European Journal of Inflammation, 2006
During the last two decades the effects of ultrasound on the transdermal permeability to a wide variety of drugs have been extensively investigated. There is still some uncertainty regarding the mechanisms involved in ultrasonic permeation enhancement, thus we investigated the effect of ultrasonic treatment on the transdermal permeation of the NSAID ...
Van der Bijl P, Basson E, Van Eyk AD, Seifart HI   +3 more
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Investigation of transdermal permeation of atorvastatinloaded microemulsions

Tropical Journal of Pharmaceutical Research, 2022
Purpose: To develop microemulsions containing atorvastatin for transdermal application, which will improve the bioavailability and reduce the side effects associated with the oral administration of atorvastatin.Methods: Atorvastatin-loaded microemulsions (MEs) were developed using tween 80 as a nonionic surfactant, isopropyl myristate, polyethylene ...
Alkrad, Jamal Alyoussef, Musa, Raad J., Al-Hijjawi, Rawan, Hussein- Al-Ali, Samer H.   +3 more
openaire   +2 more sources

In vitro transdermal permeation of fenoterol hydrobromide

Journal of Advanced Research, 2012
AbstractThe aim of this study was to determine if transdermal penetration of fenoterol, a β-agonist drug, could be enhanced and controlled by formulation modification and formulation of transdermal patches. Pre-formulation studies were performed to determine the feasibility of a transdermal dosage form of fenoterol.
Hossein Zia, Ahmed H. Elshafeey, Ahmed H. Elshafeey, Yassin El-Said Hamza, Soad Y. Amin   +4 more
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Mechanism investigation of ethosomes transdermal permeation

International Journal of Pharmaceutics: X, 2019
Ethosomes are widely used to promote transdermal permeation of both lipophilic and hydrophilic drugs, but the mechanism of interaction between the ethosomes and the skin remains unclear. In this work, it was exploded with several technologies and facilities.
Xiao-Qian Niu, Dan-Ping Zhang, Qiong Bian, Xing-Fu Feng, Hao Li, Yue-Feng Rao, Yong-Mei Shen, Fu-Neng Geng, An-Ran Yuan, Xiao-Ying Ying, Jian-Qing Gao   +10 more
openaire   +4 more sources

Effect of Microneedle Type on Transdermal Permeation of Rizatriptan [PDF]

AAPS PharmSciTech, 2017
The present study was aimed to investigate the effect of salient microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation of rizatriptan (RIZ). Studies were carried out using two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 0.9, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PMs ...
Diganta Bhusan Das, Benjamin R. Whiteside, Tao Han, Chandra Teja Uppuluri, Ashraf Sultana Shaik, Karthik J. Nair, Atul Nayak, Buchi N. Nalluri   +7 more
openaire   +3 more sources

Permeation enhancer strategies in transdermal drug delivery [PDF]

Drug Delivery, 2014
Today, ∼74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate.
Amit K. Goyal, Harneet Marwah, Tarun Garg, Goutam Rath   +3 more
openaire   +2 more sources

Electret Enhances Transdermal Drug Permeation

Biological and Pharmaceutical Bulletin, 2008
Electrets are polymeric discs that carry semi permanent electrostatic charge. These provide electrostatic potentials in the range of 500 to 3,000 V. In the current work, the effect of electret exposure on the skin permeability was investigated. Transdermal transport studies were carried out across porcine epidermis in Franz diffusion cells.
Vishwanath Anantharamaiah Boguda, Narasimha Murthy, Kotrappa Payasada   +2 more
openaire   +3 more sources

Effect of microneedles on transdermal permeation enhancement of amlodipine [PDF]

Drug Delivery and Translational Research, 2017
The present study aimed to investigate the effect of microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation enhancement of amlodipine (AMLO). Two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PM) of 0.6 mm length were employed. In the
Diganta Bhusan Das, Atul Nayak, Jyothirmayee Devineni, Karthik J. Nair, Benjamin R. Whiteside, Chandra Teja Uppuluri, Buchi N. Nalluri   +6 more
openaire   +3 more sources

Transdermal Permeation of Drugs in Various Animal Species [PDF]

Pharmaceutics, 2017
Excised human skin is utilized for in vitro permeation experiments to evaluate the safety and effect of topically-applied drugs by measuring its skin permeation and concentration. However, ethical considerations are the major problem for using human skin to evaluate percutaneous absorption.
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Microemulsion as a vehicle for transdermal permeation of nimesulide

Indian Journal of Pharmaceutical Sciences, 2006
Topical microemulsions of nimesulide, a poorly water-soluble nonsteroidal antiinflammatory drug, using olive oil as oil phase and Tween 80/iso-octanol as surfactant/co-surfactant were designed. Various concentrations of surfactant: co-surfactant (2:1, 3:1, 4:1) were used in constructing a pseudoternary phase diagram.
Sagar Pimpale, D. V. Derle, Bsh Sagar
openaire   +2 more sources