Results 31 to 40 of about 7,154 (195)

In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil

Brazilian Journal of Pharmaceutical Sciences, 2013
The aim of this study was to develop and validate a method for evaluating the release and skin permeation from transdermal nicotine patches using the vertical diffusion cell (VDC).
André Luís Morais Ruela, Eduardo Costa Figueiredo, Aline Gravinez Perissinato, Ana Carolina Zogbi Lima, Magali Benjamim Araújo, Gislaine Ribeiro Pereira   +5 more
doaj   +1 more source

Design, synthesis of novel lipids as chemical permeation enhancers and development of nanoparticle system for transdermal drug delivery. [PDF]

PLoS ONE, 2013
In the present study, we designed and developed novel lipids that include (Z)-1-(Octadec-9-en-1-yl)-pyrrolidine (Cy5T), 1, 1-Di-((Z)-octadec-9-en-1-yl)pyrrolidin-1-ium iodide (Cy5), (Z)-1-(Octadec-9-en-1-yl)-piperidine (Cy6T), and 1, 1-Di-((Z)-octadec-9 ...
Srujan Marepally, Cedar H A Boakye, Punit P Shah, Jagan Reddy Etukala, Adithi Vemuri, Mandip Singh   +5 more
doaj   +1 more source

Nanostructured lipid carriers mediated transdermal delivery of trandolapril as an impeccable therapeutic approach against hypertension: Development, characterization and in vivo evaluation

OpenNano, 2023
The study aimed to design trandolapril-embedded nanostructured lipid carriers (NLCs) transdermal patch and evaluate its in vitro drug permeation, bioavailability and pharmacokinetics.
Ramankit Jaiswal, Rita Wadetwar
doaj   +1 more source

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source

Status of surfactants as penetration enhancers in transdermal drug delivery

Journal of Pharmacy and Bioallied Sciences, 2012
Surfactants are found in many existing therapeutic, cosmetic, and agro-chemical preparations. In recent years, surfactants have been employed to enhance the permeation rates of several drugs via transdermal route.
Iti Som, Kashish Bhatia, Mohd. Yasir
doaj   +1 more source

Mimicking Human Perspiration: A Layered Microfluidic Skin Phantom With Tunable Hydrodynamics

Advanced Materials Interfaces, EarlyView.
A multilayer microfluidic skin phantom based on thermoplastic elastomers is developed to mimic human perspiration. Spatially controlled wettability enables capillary‐driven transport and controlled droplet formation at the surface, resembling sweat gland behavior.
Chunyu Yang, Ángeles Ivón Rodríguez‐Villarreal, Joan Antoni López‐Martínez, Josep Farré‐Lladós, Genís Rabost‐García, Jasmina Casals‐Terré   +5 more
wiley   +1 more source

Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery

Scientia Pharmaceutica, 2018
Curcumin is a naturally occurring substance with various pharmacological activities. It has not been developed as a drug because of its low bioavailability due to its low solubility and absorption. Piperine is a natural enhancer that is popularly used to
Chutima Jantarat, Pornpak Sirathanarun, Somruedee Boonmee, Wanida Meechoosin, Husna Wangpittaya   +4 more
doaj   +1 more source

Assessment of Finite and Infinite Dose In Vitro Experiments in Transdermal Drug Delivery

Pharmaceutics, 2021
Penetration, usually with finite dosing, provides data about the total active amount in the skin and permeation, being the most used methodology, usually with infinite dosing, leads to data about pharmacokinetic parameters.
Luisa Coderch, Ilaria Collini, Victor Carrer, Clara Barba, Cristina Alonso   +4 more
doaj   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Retinol-Loaded Mannosylerythritol Lipid Nanoliposome for Enhanced Human Skin Penetration. [PDF]

Skin Res Technol
ABSTRACT Background Functional cosmetic materials with anti‐aging properties, such as wrinkle reduction, often struggle to penetrate the skin's stratum corneum (skin barrier). Therefore, to exert anti‐aging effects, these materials must pass through the skin barrier and reach fibroblasts in the dermal layer.
Park HW, Yoo DS, Jeong CJ, Park SN.
europepmc   +2 more sources