Results 21 to 30 of about 7,154 (195)

Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies

Frontiers in Pharmacology, 2020
In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued.
Ludmilla R. Jorge, Liliam K. Harada, Erica C. Silva, Welida F. Campos, Fernanda C. Moreli, Gustavo Shimamoto, Jorge F. B. Pereira, José M. Oliveira, Matthieu Tubino, Marta M. D. C. Vila, Victor M. Balcão, Victor M. Balcão   +11 more
doaj   +1 more source

Effect of Microneedle Type on Transdermal Permeation of Rizatriptan [PDF]

AAPS PharmSciTech, 2017
The present study was aimed to investigate the effect of salient microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation of rizatriptan (RIZ). Studies were carried out using two types of MN devices viz. AdminPatch® arrays (ADM) (0.6, 0.9, 1.2 and 1.5 mm lengths) and laboratory-fabricated polymeric MNs (PMs ...
Chandrateja, Uppuluri, Ashraf Sultana, Shaik, Tao, Han, Atul, Nayak, Karthik J, Nair, Benjamin R, Whiteside, Buchi N, Nalluri, Diganta B, Das   +7 more
openaire   +2 more sources

Electret Enhances Transdermal Drug Permeation

Biological and Pharmaceutical Bulletin, 2008
Electrets are polymeric discs that carry semi permanent electrostatic charge. These provide electrostatic potentials in the range of 500 to 3,000 V. In the current work, the effect of electret exposure on the skin permeability was investigated. Transdermal transport studies were carried out across porcine epidermis in Franz diffusion cells.
Narasimha Sathyanarayana Murthy, Narasimha Sathyanarayana, Boguda, Vishwanath Anantharamaiah, Payasada, Kotrappa   +2 more
openaire   +2 more sources

Investigation of transdermal permeation of atorvastatinloaded microemulsions

Tropical Journal of Pharmaceutical Research, 2022
Purpose: To develop microemulsions containing atorvastatin for transdermal application, which will improve the bioavailability and reduce the side effects associated with the oral administration of atorvastatin.Methods: Atorvastatin-loaded microemulsions (MEs) were developed using tween 80 as a nonionic surfactant, isopropyl myristate, polyethylene ...
Alkrad, Jamal Alyoussef, Musa, Raad J., Al-Hijjawi, Rawan, Hussein- Al-Ali, Samer H.   +3 more
openaire   +2 more sources

Transdermal Film Loaded with Garlic Oil-Acyclovir Nanoemulsion to Overcome Barriers for Its Use in Alleviating Cold Sore Conditions

Pharmaceutics, 2021
The exponentially mounting cases of herpes simplex virus infection or cold sores have become a serious global concern. Acyclovir (ACV) and garlic oil (GO)-loaded lipid nanocarrier could be a promising therapeutic approach in alleviating cold sores, as ...
Alshaimaa M. Almehmady, Sarah A. Ali
doaj   +1 more source

Optimization and Characterization of Chitosan Films for Transdermal Delivery of Ondansetron

Molecules, 2013
The aim of this study was to develop novel transdermal films of ondansetron HCl with high molecular weight chitosan as matrix polymer and 2-(2-ethoxy-ethoxy) ethanol (Transcutol®) as plasticizer. In this context, firstly the physicochemical properties of
Yıldız Özsoy, Sevgi Güngör, Meryem Sedef Erdal, Aslı Sedef Can   +3 more
doaj   +1 more source

The Relationship between Solubility and Transdermal Absorption of Tadalafil [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: The aim of this study was to find a relationship between drug solubility and its transdermal permeation and find the best vehicle composition to improve transdermal permeation of Tadalafil.
Hamed Hamishehkar, Mehdi Khoshbakht, Abolghasem Jouyban, Saeed Ghanbarzadeh   +3 more
doaj   +1 more source

Permeation enhancer strategies in transdermal drug delivery

Drug Delivery, 2014
Today, ∼74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate.
Harneet, Marwah, Tarun, Garg, Amit K, Goyal, Goutam, Rath   +3 more
openaire   +2 more sources

Preparation, Characterization and Ex vivo Permeability Study of Transdermal Apixaban O/W Nanoemulsion Based Gel

Iraqi Journal of Pharmaceutical Sciences, 2020
This study designed to prepare ultrafine apixaban (APX) o/w nanoemulsion (NE) based gel with droplet size below 50 nm as a good method for transdermal APX delivery without using permeation enhancer, alternatively, the formulation components itself act as
Mustafa R. Abdulbaqi, Nawal A.Rajab
doaj   +1 more source

Alfuzosin hydrochloride transdermal films: evaluation of physicochemical, in vitro human cadaver skin permeation and thermodynamic parameters

International Brazilian Journal of Urology, 2009
Purpose: The main objective of the investigation was to develop a transdermal therapeutic system for alfuzosin hydrochloride and to study the effects of polymeric system and loading dose on the in vitro skin permeation pattern.
Satyanarayan Pattnaik, Swain Kalpana, Parthagan Choudhury, Pradeepta K. Acharya, Subrata Mallick   +4 more
doaj   +1 more source