Results 31 to 40 of about 93 (93)

A Single‐Component Adhesive Sponge Based on Blood‐Triggered and Autopenetrative Adhesion for Robust Vascular Closure

Advanced Science, EarlyView.
This study presents MonoSeal, a single‐component adhesive sponge powered by the novel Autopenetrative Adhesion (APA) mechanism. Unlike traditional adhesives, which require external stimuli, APA enables strong tissue adhesion under dynamic, high‐pressure bleeding conditions. MonoSeal's ability to autonomously seal large‐size arterial defects underscores
Rong Wang, Weishi Zheng, Yuxuan Huang, Rui Zhang, Yi Zhang, Jingying Yan, Yuqing Gu, Jingyun Xi, Tun Yuan, Hua Su, Xianzhu Zhang, Xiaozhao Wang, Shaohui Xiong, Zhenfeng Cheng, Hongwei Ouyang, Yi Hong   +15 more
wiley   +1 more source

Characterizing local and systemic exposure to clobetasol propionate in healthy subjects and patients with atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims There is a potential risk of systemic side‐effects with the use of potent corticosteroids, such as clobetasol propionate (CP). This concern is of particular interest in paediatric patients. The aim of this study was to develop and verify a physiologically based pharmacokinetic (PBPK) model to describe the local and systemic exposure to CP
Janna K. Duong, Sven van Dijkman, Gary Ong, Alexandra Marta, Adriana Ceci, Ernesto Bonifazi, Oscar Della Pasqua   +6 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Bonding of Hydrogel to Biometal Surfaces: Principles, Methods and Applications

Exploration, EarlyView.
This article reviews the research progress of hydrogel coatings on biometal surfaces, focusing on biometal surface pretreatment methods, hydrogel‐biometal bonding methods, and applications of hydrogel coatings on biometal surfaces. The article also discusses potential future applications of hydrogel coatings on biometal surfaces to provide a broader ...
Yujie Zhou, Luyao Zhang, Shufei Liu, Yan Wei, Yinchun Hu, Xiaojie Lian, Longfei Wang, Ziwei Liang, Weiyi Chen, Xin Xie, Di Huang   +10 more
wiley   +1 more source

The impact and management of hyperemesis gravidarum: Current and future perspectives

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting in pregnancy affecting around 1%–3% of pregnancies worldwide and is the most common reason for hospital admission in early pregnancy. HG can have lasting consequences for both pregnant individuals and their offspring.
L. M. van der Minnen, I. J. Grooten, C. Dean, J. Trovik, R. C. Painter   +4 more
wiley   +1 more source

An investigation of the effect of surfactants on transdermal permeation

, 1994
The aim of this study was to investigate the direct effects of surfactants on the stratum corneum, and thus propose mechanisms of action for these compounds as penetration enhancers. The main methods used in the study were: determination of the permeability of neonatal rat stratum corneum to propan-2-ol; differential scanning calorimetry (DSC); Fourier
openaire   +2 more sources

Surfactant‐Modified Progesterone‐Loaded PVP/Cellulose Fibres for Future Drug Delivery Applications in Menopause

Macromolecular Materials and Engineering, EarlyView.
Surfactant‐modified progesterone‐loaded PVP/cellulose fibres present a novel transdermal drug delivery system for hormone replacement therapy in menopause. Electrospun ethyl cellulose and cellulose acetate matrices, optimised by inclusion of polysorbate 80, are studied via SEM, FTIR, rheology, and in vitro studies and found to have improved structure ...
Omar Shafi, Michelle Swer, Un Hou Chan, Alisha Kassam, Mirkomol Mirzarakhimov, Jai Yi Huang, F Brako   +6 more
wiley   +1 more source

The Design and Development of a Dexamethasone‐Tranfersome‐PF‐127/HA Stimuli‐Responsive Hydrogel for Intra‐Articular Therapy in Osteoarthritis

Nano Select, EarlyView.
A dexamethasone‐loaded transfersome‐based hydrogel was developed for sustained intra‐articular delivery in osteoarthritis. The system showed nanoscale particles size, high drug loading capacity, and shear‐thinning behavior. It enabled smooth injection, self‐healing, and prolonged drug release for up to 6 weeks.
Atang Motaung, Thankhoe A. Rants'o, Ravindra V. Badhe, Khonzisizwe Somandi, Yahya E. Choonara   +4 more
wiley   +1 more source

Electrochemical and Nanomaterial‐Based Strategies for Nonenzymatic Glucose Detection: A Review

ChemistryOpen, EarlyView.
This review critically evaluates emerging nonenzymatic glucose sensing platforms, smartphone‐integrated devices, and fifth‐generation strategies for continuous noninvasive glucose monitoring. Electrochemical glucose sensing technologies have undergone significant evolution, with continual advancements aimed at improving sensitivity, selectivity, and ...
Reagan Aviha, Gymama Slaughter
wiley   +1 more source