Results 41 to 50 of about 6,917 (245)
Iraqi Journal of Pharmaceutical Sciences, 2020 This study designed to prepare ultrafine apixaban (APX) o/w nanoemulsion (NE) based gel with droplet size below 50 nm as a good method for transdermal APX delivery without using permeation enhancer, alternatively, the formulation components itself act as
Mustafa R. Abdulbaqi, Nawal A.Rajab
doaj +1 more source
The Relationship between Solubility and Transdermal Absorption of Tadalafil [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: The aim of this study was to find a relationship between drug solubility and its transdermal permeation and find the best vehicle composition to improve transdermal permeation of Tadalafil.
Hamed Hamishehkar +3 more
doaj +1 more source
Microemulsion as a vehicle for transdermal permeation of nimesulide
Indian Journal of Pharmaceutical Sciences, 2006 Topical microemulsions of nimesulide, a poorly water-soluble nonsteroidal antiinflammatory drug, using olive oil as oil phase and Tween 80/iso-octanol as surfactant/co-surfactant were designed. Various concentrations of surfactant: co-surfactant (2:1, 3:1, 4:1) were used in constructing a pseudoternary phase diagram.
Sagar Pimpale, D. V. Derle, Bsh Sagar
openaire +2 more sources
In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil
Brazilian Journal of Pharmaceutical Sciences, 2013 The aim of this study was to develop and validate a method for evaluating the release and skin permeation from transdermal nicotine patches using the vertical diffusion cell (VDC).
André Luís Morais Ruela +5 more
doaj +1 more source
Status of surfactants as penetration enhancers in transdermal drug delivery
Journal of Pharmacy and Bioallied Sciences, 2012 Surfactants are found in many existing therapeutic, cosmetic, and agro-chemical preparations. In recent years, surfactants have been employed to enhance the permeation rates of several drugs via transdermal route.
Iti Som, Kashish Bhatia, Mohd. Yasir
doaj +1 more source
Design, synthesis of novel lipids as chemical permeation enhancers and development of nanoparticle system for transdermal drug delivery. [PDF]
PLoS ONE, 2013 In the present study, we designed and developed novel lipids that include (Z)-1-(Octadec-9-en-1-yl)-pyrrolidine (Cy5T), 1, 1-Di-((Z)-octadec-9-en-1-yl)pyrrolidin-1-ium iodide (Cy5), (Z)-1-(Octadec-9-en-1-yl)-piperidine (Cy6T), and 1, 1-Di-((Z)-octadec-9 ...
Srujan Marepally +5 more
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Scientia Pharmaceutica, 2018 Curcumin is a naturally occurring substance with various pharmacological activities. It has not been developed as a drug because of its low bioavailability due to its low solubility and absorption. Piperine is a natural enhancer that is popularly used to
Chutima Jantarat +4 more
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Iraqi Journal of Pharmaceutical Sciences, 2022 Objective: the idea of this study to improve transdermal permeability of Methotrexate using eucalyptus oil, olive oil and peppermint oil as enhancers. Method: eucalyptus oil (2% and 4%), peppermint oil (2% and 4%) and olive oil (2% and 4%) all used as ...
Jamal Ali Ashoor +4 more
doaj +1 more source
H2O2‐Generating Advanced Nanomaterials for Cancer Treatment
Advanced Functional Materials, EarlyView.H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie +8 more
wiley +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source