Results 61 to 70 of about 93,495 (232)

Ionic liquid-iontophoresis mediates transdermal delivery of sparingly soluble drugs

Drug Delivery
Low solubility restricted transdermal penetration of drugs. We aimed to develop a novel ionic liquid-iontophoresis (IL-IS) technology and assess their efficacy and primary factors in facilitating transdermal drug delivery.
Wenyan Gao, Wenmin Xing, Zhan Tang, Qiao Wang, Wenying Yu, Qi Zhang   +5 more
doaj   +1 more source

Permeability Enhancement of Methotrexate Transdermal Gel using Eucalyptus oil, Peppermint Oil and Olive Oil(Conference Paper )#

Iraqi Journal of Pharmaceutical Sciences, 2022
Objective: the idea of this study to improve transdermal permeability of Methotrexate using eucalyptus oil, olive oil and peppermint oil as enhancers. Method: eucalyptus oil (2% and 4%), peppermint oil (2% and 4%) and olive oil (2% and 4%) all used as ...
Jamal Ali Ashoor, Jinan M. Mohsin, Hussein Mohammed Mohsin, Basam W. Mahde, Mowafaq M. Gareeb   +4 more
doaj   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities

Pharmaceutics, 2020
The transdermal route of drugs has received increased attention in recent years due to numerous advantages over the oral and injectable routes, such as avoidance of the hepatic metabolism, protection of drugs from the gastrointestinal tract, sustained ...
Rabin Neupane, Sai H.S. Boddu, Jwala Renukuntla, R. Jayachandra Babu, Amit K. Tiwari   +4 more
doaj   +1 more source

Novel mono, di and tri-fatty acid esters bearing secondary amino acid ester head groups as transdermal permeation enhancers

, 2018
Mono-oleate derivative (MOAPE) enhancing in vitro transdermal permeation of tenofovir.
M. Jadhav, T. Govender, R. S. Kalhapure, S. Rambharose   +3 more
core   +1 more source

Transdermal Delivery of Nicardipine: An Approach to In Vitro Permeation Enhancement [PDF]

Drug Delivery, 2002
Nicardipine hydrochloride (NC-HCl), a calcium channel blocker for the treatment of chronic stable angina and hypertension, seems to be a potential therapeutic transdermal system candidate, mainly due to its low dose, short half-life, and high first-pass metabolism.
Reza, Aboofazeli, Hossein, Zia, Thomas E, Needham   +2 more
openaire   +2 more sources

Use of "bricks and mortar" model to predict transdermal permeation: Model development and initial validation

, 2020
Presented in this paper is a general purpose computer model for predicting transdermal permeation of solutes in vivo. The "bricks and mortar" model is employed to represent the stratum corneum (SC), the main barrier to transdermal permeation. Transdermal
Chen, L, Han, L, Lian, G
core   +2 more sources

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

The permeation rate and transdermal amount at 24 h of naringenin-loaded elastic liposomes through rat skin.

, 2015
The permeation rate and transdermal amount at 24 h of naringenin-loaded elastic liposomes through rat skin.
Pao-Chu Wu (605395), Ming-Jun Tsai (605393), Jhih-Wun Fang (767717), Yaw-Bin Huang (605394), Yaw-Syan Fu (297430)   +4 more
core   +1 more source

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source