Recent developments in skin mimic systems to predict transdermal permeation [PDF]
, 2015 In recent years there has been a drive to create experimental techniques that can facilitate the accurate and precise prediction of transdermal permeation without the use of in vivo studies.
Waters, Laura J.
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Drug crystallization – implications for topical and transdermal delivery [PDF]
, 2016 INTRODUCTION: Crystallization of actives in skin following topical application was suggested by studies in the 1950s and 1960s but is poorly understood.
Hadgraft, J, Lane, ME
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Transdermal delivery of ibuprofen utilizing a novel solvent free pressure sensitive adhesive (PSA) : TEPI® technology [PDF]
, 2017 Purpose The main objective of this present study was the investigation of potential novel transdermal patch technology (TEPI®) delivering ibuprofen as the active pharmaceutical ingredient (API) using a novel poly(ether-urethane)-silicone crosslinked ...
Haddleton, David M. +3 more
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In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil
Brazilian Journal of Pharmaceutical Sciences, 2013 The aim of this study was to develop and validate a method for evaluating the release and skin permeation from transdermal nicotine patches using the vertical diffusion cell (VDC).
André Luís Morais Ruela +5 more
doaj +1 more source
Design, synthesis of novel lipids as chemical permeation enhancers and development of nanoparticle system for transdermal drug delivery. [PDF]
PLoS ONE, 2013 In the present study, we designed and developed novel lipids that include (Z)-1-(Octadec-9-en-1-yl)-pyrrolidine (Cy5T), 1, 1-Di-((Z)-octadec-9-en-1-yl)pyrrolidin-1-ium iodide (Cy5), (Z)-1-(Octadec-9-en-1-yl)-piperidine (Cy6T), and 1, 1-Di-((Z)-octadec-9 ...
Srujan Marepally +5 more
doaj +1 more source
OpenNano, 2023 The study aimed to design trandolapril-embedded nanostructured lipid carriers (NLCs) transdermal patch and evaluate its in vitro drug permeation, bioavailability and pharmacokinetics.
Ramankit Jaiswal, Rita Wadetwar
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Evaluation of the In Vitro Permeation Parameters of Topical Diclofenac Sodium from Transdermal Pentravan<sup>®</sup> Products and Hydrogel Celugel Through Human Skin. [PDF]
Pharmaceuticals (Basel)Adamiak-Giera U +11 more
europepmc +2 more sources
Microemulsion as a vehicle for transdermal permeation of nimesulide
Indian Journal of Pharmaceutical Sciences, 2006 Topical microemulsions of nimesulide, a poorly water-soluble nonsteroidal antiinflammatory drug, using olive oil as oil phase and Tween 80/iso-octanol as surfactant/co-surfactant were designed. Various concentrations of surfactant: co-surfactant (2:1, 3:1, 4:1) were used in constructing a pseudoternary phase diagram.
Sagar Pimpale, D. V. Derle, Bsh Sagar
openaire +2 more sources
A two-phase two-layer model for transdermal drug delivery and percutaneous absorption
, 2014 One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery).
de Monte, Filippo, Pontrelli, Giuseppe
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A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine. [PDF]
, 2017 BackgroundDFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM).
Allenby, Kent +5 more
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