Results 61 to 70 of about 93 (93)

Detailed Analysis of Back Pain: A Cross‐Sectional Study of Epidemiology and Previous Therapies in a German Population

Pain Practice, Volume 25, Issue 7, September 2025.
ABSTRACT Background Diagnosing cLBP is complex due to its heterogeneity, lack of definitive biomarkers, and the subjective nature of pain. This study aims to analyze cLBP patients comprehensively, characterizing demographic and clinical profiles of patients and evaluating the types and effectiveness of previous treatments.
Bernhard U. Hoehl, Nima Taheri, Luis Alexander Becker, Lukas Mödl, Lukas Schönnagel, Christoph Stein, Matthias Pumberger, Hendrik Schmidt   +7 more
wiley   +1 more source

Enhanced Skin Permeation and Pigmentation Reduction Effects of a Novel Tranexamic Acid‐Mandelic Acid Ion‐Pairing Complex

Skin Research and Technology, Volume 31, Issue 9, September 2025.
ABSTRACT Purpose This study investigated the enhanced skin permeation and pigmentation reduction effects of an ion‐pair complex formed between tranexamic acid (TXA) and mandelic acid (MA). The TXA‐MA complex demonstrated superior skin permeability and greater inhibition of cytokine expression compared to TXA alone, ultimately proving more effective in ...
Hyungjoon Jeon, Nojin Park, Jong Gu Won, Yong Won Shin, Jiwon Choi, Kyoungin Min, Eunjung Choi, Chang Kyu Kim, Sang‐Wook Park, Nam Seo Son   +9 more
wiley   +1 more source

Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi, Liesbet Lagae, Johanna Bolander   +2 more
wiley   +1 more source

EFFECT OF NATURAL ENHANCERS IN TRANSDERMAL PERMEATION OF FLUOXETINE [PDF]

International Journal of Innovations in Biological and Chemical Sciences , 2016
Dashrath Singh, Amrish Chandra
openaire   +2 more sources

Eutectic formulations of Ibuprofen to enhance transdermal permeation

European Journal of Pharmaceutical Sciences, 1996
Adrian C. Williams, P.W. Stott, Brian W. Barry   +2 more
openaire   +2 more sources

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Homoharringtonine is a transdermal granular permeation enhancer

Biochemical and Biophysical Research Communications, 2022
Although modulation of claudin-1-based tight junction (TJ) in stratum granulosum is an option for transdermal absorption of drugs, granular permeation enhancers have never been developed. We previously found that homoharringtonine (HHT), a natural alkanoid, weakened intestinal epithelial barrier with changing expression and cellular localization of TJ ...
Akihiro, Watari, Kana, Fujiwara, Kiyohito, Yagi, Keisuke, Tachibana, Takeshi, Katsurada, Akira, Myoui, Masuo, Kondoh   +6 more
openaire   +2 more sources

Physicochemical aspects of transdermal permeation

Journal of Controlled Release, 1987
Abstract The nature and state of lipids are often important regulators in many membrane functions and properties. Current studies probe the physicochemical aspects of the enhanced permeabilities of lipophilic solutes through hairless mouse stratum corneum.
Steven L. Krill, William J. Lambert, Kristine Knutson, William I. Higuchi   +3 more
openaire   +2 more sources

Permeation Enhancers for Transdermal Drug Delivery

Drug Development and Industrial Pharmacy, 2000
The transdermal route has been recognized as one of the highly potential routes of systemic drug delivery and provides the advantage of avoidance of the first-pass effect, ease of use and withdrawal (in case of side effects), and better patient compliance.
V. R. Sinha, Maninder Kaur
openaire   +3 more sources

In Vitro Studies on Transdermal Permeation of Butorphanol

Drug Development and Industrial Pharmacy, 2007
The influence of the donor vehicles pH and the addition of laurocapram or transkarbam 12 as permeation enhancers on the transdermal permeation of butorphanol through human skin were examined with the aim of finding out about its possible use in the transdermal delivery system.
Michal Svozil, Pavel Mericka, Pavel Dolezal, Alexander Hrabalek   +3 more
openaire   +3 more sources

Alaptide as Transdermal Permeation Modifier

2015
Based on the fact that alaptide is able to influence the creation and function of keratinocytes, it was supposed that alaptide could be used as a transdermal permeation modifier. Various APIs (bases, acids, salts, neutral molecules, small molecules, steroid-like molecules) were tested on their transdermal permeation in the mixture with micronized and ...
Josef Jampilek, Jiří Dohnal
openaire   +2 more sources