Results 71 to 80 of about 93 (93)
Some of the next articles are maybe not open access.
Solubility and in vitro transdermal permeation of nifedipine
International Journal of Pharmaceutics, 1997Abstract The solubilities of a hydrophobic drug, nifedipine, in a diverse panel of solvent and cosolvent systems were determined experimentally at room temperature. The observed solubilities were examined for deviations from regular solution solubilities as calculated by the Hildebrand and Scott Equation.
Hossein Zia +2 more
openaire +2 more sources
Transdermal permeation of neutral molecules by skin electroporation
Journal of Controlled Release, 1998Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold.
Véronique Préat +2 more
openaire +3 more sources
Transdermal Permeation Modulation by Cyclodextrins: A Mechanistic Study
Pharmaceutical Development and Technology, 1998The purpose of this study was to investigate permeation modulation by beta- and 2-hydroxypropyl-beta-cyclodextrins (beta-CD and HP-beta-CD, respectively) alone and complexed with penetration enhancers for the test drugs 5-fluorouracil and estradiol through human skin, and to probe the value of the CDs in a barrier cream against toluene exposure ...
Syed R. S. Shatri +2 more
openaire +3 more sources
Transdermal self-permeation enhancement of ibuprofen
Journal of Controlled Release, 2004The objective of this study was to prepare saturated solutions of ibuprofen, of different concentrations, and to investigate their effect on permeation of ibuprofen across rat epidermis. Ibuprofen saturated solutions were prepared using 0.1, 0.2, 0.3 and 0.4 M disodium hydrogen phosphate solution (DHP).
openaire +3 more sources
Amino acid derivatives as transdermal permeation enhancers
Journal of Controlled Release, 2013Transdermal permeation enhancers are compounds that temporarily decrease skin barrier properties to promote drug flux. In this study, we investigated enhancers with amino acids (proline, sarcosine, alanine, β-alanine, and glycine) attached to hydrophobic chain(s) via a biodegradable ester link.
Katarína Tükörová +11 more
openaire +3 more sources
Transkarbams with terminal branching as transdermal permeation enhancers
Bioorganic & Medicinal Chemistry Letters, 2008Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear ...
Petr Kosák +5 more
openaire +3 more sources
An Electrochemical Transdermal Patch for Permeation Enhancement
2017A novel electrochemical patch is described that works by the hydrolysis of water in a hydrogel between two suitable electrodes that produces a strongly enhanced drug flux through the skin. This non-iontophoretic mechanism requires only a short voltage application (60 s) yet produces enhanced skin permeation over up to 5 h.
Elisabeth Meyer +3 more
openaire +2 more sources
Design of improved permeation enhancers for transdermal drug delivery
Journal of Pharmaceutical Sciences, 2009One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical penetration enhancers (CPEs) by integrating nonlinear, theory-based ...
Krishna M. Yerramsetty +6 more
openaire +3 more sources
Transdermal Permeation: Physiological and Physicochemical Aspects
1991Prior to the introduction of transdermal delivery systems, topical delivery of drugs was achieved by application of ointments or creams to intact skin. When the goal was systemic therapy (e.g., nitroglycerin and estradiol ointments), reproducible dosing was extremely difficult to achieve because of the difficulty in applying uniform amounts of ointment
S. S. Hwang, M. Southam, K. C. Nichols
openaire +2 more sources
Sucrose Esters as Transdermal Permeation Enhancers
2015Surfactants are widely used excipients in topical formulations, not only for their solubilizing and emulsifying properties but also for their well-known capacity to enhance drug permeation. Although nonionic surfactants are frequently chosen because of their mild effect on the skin, they share a low efficacy as permeation enhancers.
Elizabeth Piñón-Segundo +2 more
openaire +2 more sources