Results 81 to 90 of about 93 (93)
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Transdermal permeation of vasopressin. II. Influence of Azone on in vitro and in vivo permeation
International Journal of Pharmaceutics, 1989Abstract Different enhancers were evaluated by measuring in vitro diffusion of aqueous vasopressin solution through excised rat skin after pretreatment with enhancers. Azone was found to be the most effective enhancer studied, increasing the flux about 15 times.
Partha S. Banerjee, Wolfgang A. Ritschel
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Permeation enhancers in transdermal drug delivery: benefits and limitations
Expert Opinion on Drug Delivery, 2020Introduction: Transdermal drug delivery has several clinical benefits over conventional routes of drug administration. To open the transdermal route for a wider range of drugs, including macromolecules, numerous physical and chemical techniques to overcome the natural low skin permeability have been developed.Areas covered: This review focuses on ...
Andrej Kováčik +2 more
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Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers
Journal of Controlled Release, 2005The purpose of this work was to develop a novel approach to transdermal permeation enhancer design, based on utilizing some favorable properties of their metabolites. As an example of this concept, a series of carbamic acid salts of tranexamic acid (TXA) esters was synthesized, because TXA was previously shown to improve skin barrier homeostasis ...
Tomáš Holas +4 more
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Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: In vivo
Colloids and Surfaces B: Biointerfaces, 2006In vivo transdermal permeation of tetracaine hydrochloride encapsulated in lecithin water-in-oil and oil-in-water microemulsion was studied. The effect of the composition of the lecithin microemulsion on analgesic response of tetracaine hydrochloride was evaluated on Wistar rats by tail flick method.
Jagdish Chander +2 more
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Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids
Cannabis and Cannabinoid ResearchIntroduction: This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids. Methods: A systematic and comprehensive literature search across academic databases, search engines, and online sources to identify relevant literature on the
Atefeh Torabi +2 more
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Amphiphilic Transdermal Permeation Enhancers: Structure-Activity Relationships
Current Medicinal Chemistry, 2005Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of this methodology. One of the approaches used to enlarge the number of transdermally-applicable drugs uses permeation enhancers.
Kateřina Vávrová +2 more
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Transdermal permeation enhancement of N-trimethyl chitosan for testosterone
International Journal of Pharmaceutics, 2008The aim of this study was to evaluate the transdermal permeation enhancement of N-trimethyl chitosan (TMC) with different degrees of quaternization (DQ). TMCs with DQ of 40 and 60% (TMC40 and TMC60) were synthesized and characterized by (1)H NMR. Testosterone (TS) used as an effective drug, four different gels were prepared without enhancer, with 5 ...
Wen He, Mian Zhang, Xianxi Guo
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Transdermal delivery of naloxone: ex vivo permeation studies
International Journal of Pharmaceutics, 1999The purpose of this investigation was to study the feasibility of transdermal drug delivery of the potent opioid antagonist naloxone. The pharmacokinetic profile of naloxone makes it a suitable candidate for transdermal delivery. Ex vivo permeation of naloxone through excised rat skin was studied using a diffusion cell.
Ramesh Panchagnula +2 more
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In vitro transdermal permeation and penetration properties for transfersomes of brucine
China Journal of Chinese Materia Medica, 2016To prepare the liposomes and transfersomes of brucine, characterize their pharmaceutical properties, and compare their in vitro transdermal permeation properties. The liposomes and transfersomes of brucine were prepared by ammonium sulfate gradient method to investigate their pharmaceutical properties such as the particle size, encapsulation efficiency
Jun Chen +4 more
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Transdermal Absorption of Radioprotectors Using Permeation-Enhancing Vehicles
Radiation Research, 1990Radioprotectors are not currently used clinically due to concerns regarding toxicity and uncertainties regarding tumor protection. Topical radioprotection of skin might find clinical applications with protectors such as WR-2721, but laboratory studies in which protectors have been applied in water have not been promising. We have studied the absorption
Albert A. Lamperti +2 more
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