Results 201 to 210 of about 304,117 (294)

Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote immune evasion in head and neck squamous cell carcinoma. [PDF]

Commun Biol
Ando T, Okamoto K, Sato K, Goto Y, Izumi H, Kataoka N, Ueda Y, Kobayashi Y, Omachi K, Maeda Y, Furusho H, Iglesias-Bartolome R, Yoshimoto T, Shintani T, Yanamoto S, Miyauchi M, Gutkind JS, Kajiya M.   +17 more
europepmc   +1 more source

Measuring Blood Plasma Glutamine Levels Using a Nanopore‐Based Sensor

Advanced Healthcare Materials, EarlyView.
Glutamine (GLN) is a biomarker useful for predicting toxic ammonia accumulation. Here, we used a biosensor based on the Cytolysin A (ClyA) nanopore coupled with the GLN‐specific protein substrate‐binding domain 2 (SBD2) to demonstrate real‐time measurement of GLN in blood plasma, highlighting the potential for future point‐of‐care applications ...
Sofia B. Relvas, Iris M. Kormelink, Sandra Michel‐Souzy, Florian L. R. Lucas, Nieck J. van der Heide, Hans R. Waterham, Ramon Versteeg, Judith Jans, Loes I. Segerink, Carsten Wloka   +9 more
wiley   +1 more source

From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review). [PDF]

Mol Med Rep
Wang X, Deng W, Tu S, Tang H, Yin K, Zhu X.   +5 more
europepmc   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice. [PDF]

Adv Sci (Weinh)
Hong Z, Zhang Y, Zhang J, Liu H, Liu Q, Li Y, Yang L, Li L, Liu Z, Yuan Z, Lu Z, Chen Y, Li Y, Jiang Y, Liu T.   +14 more
europepmc   +1 more source

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source

Biocompatible Conjugated Electrospinning Nanofibrous Membrane With Self‐Powered Piezoelectric Capacity for Accelerated Wound Healing

Advanced Healthcare Materials, EarlyView.
A self‐powered PCL/gelatin‐PVDF‐TrFE/MXene conjugated electrospun membrane integrates biocompatibility with enhanced piezoelectric responsiveness. Mechanical deformation is converted into localized electrical signals that stimulate wound‐repair cells proliferation and migration, promote angiogenesis and tissue remodeling, and accelerate full‐thickness ...
Diandian Li, Ke Wu, Yangyang Lu, Qinglan Xia, Jialong Chen, Yifan Zhang, Zhaoyu Chen, Zhiyuan She, Junjin Jie, Juzi Xia, Muran Zhou, Aimei Zhong   +11 more
wiley   +1 more source

LncRNA <i>RAMS11</i>-dependent <i>NOTCH3</i> activation drives tumor progression in non-small cell lung cancer. [PDF]

NAR Cancer
Jeffers GG, Kim Y, White NM, Lin L, Rozycki EB, Ly A, Maher CA.   +6 more
europepmc   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Efficient NK cell transduction with VSV-G-pseudotyped lentiviral vectors. [PDF]

Mol Ther Adv
Järvelä E, Koski J, Jahan F, Tuhkala A, Saari M, Elmadani M, Salokas K, Veltman L, Andersson L, Kerkelä E, Can H, Nyman M, Ylä-Herttuala S, Varjosalo M, Schenkwein D, Paavilainen H, Vettenranta K, Korhonen M, Göös H.   +18 more
europepmc   +1 more source