Results 211 to 220 of about 83,780 (258)

Enhanced Cochlear Transduction by AAV9 with High-Concentration Sucrose

Human Gene Therapy, 2023
The inner ear is a primary lesion in sensorineural hearing loss and has been a target in gene therapy. The efficacy of gene therapy depends on achieving sufficient levels of transduction at a safe vector dose. Vectors derived from various adeno-associated viruses (AAVs) are predominantly used to deliver therapeutic genes to inner ear cells.
Masao Noda, Ryota Koshu, Mari Shimada Dias, Chizu Saito, Naomi Takino, Mika Ito, Hidekane Yoshimura, Makoto Ito, Shin-ichi Muramatsu   +8 more
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Photochemically enhanced adenoviral transduction in a multicellular environment

Photochemical & Photobiological Sciences, 2006
Photochemical internalization (PCI) enhances adenovirus (Ad) transgene expression in a variety of cell lines in vitro. However, measurements of the photochemical effect on transduction in multicellular environments are lacking. In this study, spheroids of DU 145 prostate cancer cells were used as a model to evaluate Ad serotype 5 (Ad5) transduction in ...
Anette, Bonsted, Birgit Øvstebø, Engesaeter, Anders, Høgset, Kristian, Berg   +3 more
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Enhanced Neuroblastoma Transduction for an Improved Antitumor Vaccine

Journal of Surgical Research, 1999
A recent clinical trial of an antineuroblastoma vaccine used adenovirus serotype 5 (Ad5) vectors to transduce autologous tumor cells with the gene encoding IL-2. A method to improve transduction efficiency was sought to enable the use of lower viral titers, especially when in situ adenoviral-mediated tumor cell transduction is considered.A chimeric ...
A M, Davidoff, S C, Stevenson, A, McClelland, S J, Shochat, E F, Vanin   +4 more
openaire   +2 more sources

Virosomes: Cationic Liposomes Enhance Retroviral Transduction

Nature Biotechnology, 1996
Retrovirus-derived vectors are overwhelmingly preferred over other methods for ex vivo gene therapy because they provide permanent integration of foreign genes into cellular DNA. In comparison, cationic lipids mediate efficent gene transfer, but expression is transient.
C P, Hodgson, F, Solaiman
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Squeezing-enhanced optomechanical transduction sensitivity

2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC, 2013
High-sensitivity interferometric detection of mechanical displacements has received much attention over the past decades, due to its vast field of applicability, e.g. in gravitational wave detection, cantilever-based single spin detection, and the quest to reveal quantum effects in mesoscopic mechanical systems.
Hoff, Ulrich B., Harris, Glen I., Madsen, Lars S., Kerdoncuff, Hugo, Lassen, Mikael, Nielsen, Bo M., Bowen, Warwick P., Andersen, Ulrik L.   +7 more
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Magnetic Nanoparticles Enhance Adenovirus Transduction In Vitro and In Vivo

Pharmaceutical Research, 2011
Adenoviruses are among the most powerful gene delivery systems. Even if they present low potential for oncogenesis, there is still a need for minimizing widespread delivery to avoid deleterious reactions. In this study, we investigated Magnetofection efficiency to concentrate and guide vectors for an improved targeted delivery.Magnetic nanoparticles ...
Sapet, Cédric, Pellegrino, Christophe, Laurent, Nicolas, Sicard, Flavie, Zelphati, Olivier   +4 more
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Signal Transduction Pathways in Enhanced Microvascular Permeability

Microcirculation, 2000
ABSTRACTWe have been investigating the molecular mechanisms underlying pathophysiological regulation of microvascular permeability on isolated venules and cultured venular endothelial monolayers. Physiological approaches have been employed in combination with molecular analyses to probe the signal transduction pathways leading to enhanced microvascular
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Enhancement of Retroviral Transduction by Cationic Liposomes

2003
Publisher Summary This chapter discusses the enhancing effect of N-2,3-(dioleyloxy) propyl-N,N,N-trimethylammonium chloride (DOTMA) liposomes on HIV-1/infection, which is CD4-dependent. The complexation of retroviral vectors with cationic liposomes results in an increased transduction efficiency.
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Haircell forward and reverse transduction: Differential suppression and enhancement

Hearing Research, 1990
Cochlear outer haircells are believed to play a significant role in an amplification process which greatly enhances inner ear sensitivity. Haircell forward (mechanical-to-electrical) and reverse (electrical-to-mechanical) transduction may be involved.
A E, Hubbard, D C, Mountain
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Enhanced chemi-mechanical transduction at nanostructured interfaces

Chemical Physics Letters, 2001
Interfacial molecular recognition processes can be converted into mechanical responses via modulation of surface stress. We demonstrate dramatic enhancement in this transduction when quasi 3-D interfaces with nano-size features are used. Microcantelever surfaces are modified with gold nanospheres or granular films and functionalized with macrocycle ...
Nickolay V. Lavrik, Christopher A. Tipple, Michael J. Sepaniak, Panos G. Datskos   +3 more
openaire   +1 more source