Results 231 to 240 of about 304,117 (294)

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Genome architecture: nuclear context links noncoding variants to transcriptional programs. [PDF]

Signal Transduct Target Ther
El-Osta A, El-Osta A.
europepmc   +1 more source

A Noninvasive Approach to Study Localized Forces in 3D Epithelia

Advanced Materials, EarlyView.
Epithelial morphogenesis depends on dynamic mechanical coupling between adhesion complexes and the cytoskeleton, yet its regulation in polarized 3D tissues remains elusive. We developed a noninvasive strategy using cell‐like elastic microbeads to quantify local forces in intact epithelia.
Niels Gouirand, Muhamet Ibrahimi, Claire Valotteau, Brice Lecouffe, André Le Bivic, Dominique Massey‐Harroche, Felix Rico, Matthias Merkel, Delphine Delacour, Elsa Bazellières   +9 more
wiley   +1 more source

Understanding Operando Water Management in Hydroxide‐Exchange‐Membrane Fuel Cells

Advanced Materials Interfaces, EarlyView.
Effective water management is vital for high‐performance hydroxide‐exchange‐membrane fuel cells. Using a custom water‐flux station, this study quantifies how membrane thickness, microporous layers, and operating conditions dictate internal water transport.
Catherine M. Weiss, Shiyi Wang, Brian P. Setzler, Yushan Yan, Adam Z. Weber   +4 more
wiley   +1 more source

Conserved Regulatory DNA Methylation in Human and MYC/PI3K-Driven Murine EBV-Negative Burkitt Lymphoma. [PDF]

Cancers (Basel)
Glaser S, Ren M, Sander S, Siebert R.
europepmc   +1 more source

Light‐Controlled Localized Delamination and Blistering of Azobenzene‐Containing Polymer Thin Films in an Aqueous Environment

Advanced Materials Interfaces, EarlyView.
When exposed to light of a defined wavelength, the photoisomerization of azobenzene chromophores leads to polymer reorientation, generating stresses that result in solvent‐facilitated localized delamination of the film from the substrate. Additionally, blisters that form spontaneously when exposed to an aqueous environment can be manipulated via ...
James Robert Benson, Jonas Strobelt, Nino Lomadze, Svetlana Santer, Stephan Eickelmann   +4 more
wiley   +1 more source

Temporal dynamics of intragenic enhancer RNAs regulate Lin28a expression in response to external stimuli in embryonic stem cells. [PDF]

Nucleic Acids Res
Lee H, Oh M, Moon J, Jeong S, Jang Y, Lee MH, Um D, Lee D, Kim TK, Kim SK.   +9 more
europepmc   +1 more source

Advances in Halide Perovskites for Photon Radiation Detectors

Advanced Materials Technologies, EarlyView.
This work highlights recent progress in perovskite‐based photon radiation detectors, covering organic–inorganic hybrid, inorganic, lead‐free double, and vacancy‐ordered halide perovskites. Their detection performance is compared, material‐specific advantages and challenges are examined, and provides insight into current limitations and future ...
Liangling Wang, Jieqi Wang, Xiaojun Cui, Carsten Ronning   +3 more
wiley   +1 more source

A prostate cancer-specific super-enhancer at 1q42.3 regulates the CAPN2 and KRT19. [PDF]

J Biol Chem
Zhao Z, Bai Y, Wang Q, Zhao Y, Jiang Y, Li H, Yang Z, Liu X, Zhang L, Zhao Z, Qian Y, Li P, Shi J, Lu W.   +13 more
europepmc   +1 more source

A molecular and spinal circuit basis for the functional segregation of itch and pain. [PDF]

Neuron
Noh MC, Corrigan KA, Williams SG, Peirs C, Leone MJ, Headrick DJ, Guvercin M, Lee S, Phan BN, Zhao X, Henry DA, Yeramosu D, Babu S, Brown AR, Van De Weerd R, Dum RP, Mathys H, Pfenning AR, Seal RP.   +18 more
europepmc   +1 more source