Results 251 to 260 of about 304,117 (294)

Enhanced Neuroblastoma Transduction for an Improved Antitumor Vaccine

Journal of Surgical Research, 1999
A recent clinical trial of an antineuroblastoma vaccine used adenovirus serotype 5 (Ad5) vectors to transduce autologous tumor cells with the gene encoding IL-2. A method to improve transduction efficiency was sought to enable the use of lower viral titers, especially when in situ adenoviral-mediated tumor cell transduction is considered.A chimeric ...
A M, Davidoff, S C, Stevenson, A, McClelland, S J, Shochat, E F, Vanin   +4 more
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Virosomes: Cationic Liposomes Enhance Retroviral Transduction

Nature Biotechnology, 1996
Retrovirus-derived vectors are overwhelmingly preferred over other methods for ex vivo gene therapy because they provide permanent integration of foreign genes into cellular DNA. In comparison, cationic lipids mediate efficent gene transfer, but expression is transient.
C P, Hodgson, F, Solaiman
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Squeezing-enhanced optomechanical transduction sensitivity

2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC, 2013
High-sensitivity interferometric detection of mechanical displacements has received much attention over the past decades, due to its vast field of applicability, e.g. in gravitational wave detection, cantilever-based single spin detection, and the quest to reveal quantum effects in mesoscopic mechanical systems.
Hoff, Ulrich B., Harris, Glen I., Madsen, Lars S., Kerdoncuff, Hugo, Lassen, Mikael, Nielsen, Bo M., Bowen, Warwick P., Andersen, Ulrik L.   +7 more
openaire   +2 more sources

Signal Transduction Pathways in Enhanced Microvascular Permeability

Microcirculation, 2000
ABSTRACTWe have been investigating the molecular mechanisms underlying pathophysiological regulation of microvascular permeability on isolated venules and cultured venular endothelial monolayers. Physiological approaches have been employed in combination with molecular analyses to probe the signal transduction pathways leading to enhanced microvascular
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Magnetic Nanoparticles Enhance Adenovirus Transduction In Vitro and In Vivo

Pharmaceutical Research, 2011
Adenoviruses are among the most powerful gene delivery systems. Even if they present low potential for oncogenesis, there is still a need for minimizing widespread delivery to avoid deleterious reactions. In this study, we investigated Magnetofection efficiency to concentrate and guide vectors for an improved targeted delivery.Magnetic nanoparticles ...
Sapet, Cédric, Pellegrino, Christophe, Laurent, Nicolas, Sicard, Flavie, Zelphati, Olivier   +4 more
openaire   +2 more sources

Enhancement of Retroviral Transduction by Cationic Liposomes

2003
Publisher Summary This chapter discusses the enhancing effect of N-2,3-(dioleyloxy) propyl-N,N,N-trimethylammonium chloride (DOTMA) liposomes on HIV-1/infection, which is CD4-dependent. The complexation of retroviral vectors with cationic liposomes results in an increased transduction efficiency.
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Haircell forward and reverse transduction: Differential suppression and enhancement

Hearing Research, 1990
Cochlear outer haircells are believed to play a significant role in an amplification process which greatly enhances inner ear sensitivity. Haircell forward (mechanical-to-electrical) and reverse (electrical-to-mechanical) transduction may be involved.
A E, Hubbard, D C, Mountain
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Enhanced chemi-mechanical transduction at nanostructured interfaces

Chemical Physics Letters, 2001
Interfacial molecular recognition processes can be converted into mechanical responses via modulation of surface stress. We demonstrate dramatic enhancement in this transduction when quasi 3-D interfaces with nano-size features are used. Microcantelever surfaces are modified with gold nanospheres or granular films and functionalized with macrocycle ...
Nickolay V. Lavrik, Christopher A. Tipple, Michael J. Sepaniak, Panos G. Datskos   +3 more
openaire   +1 more source

Noise-enhanced energy transduction of molecular machinery

Chemical Physics Letters, 2002
We have numerically investigated the enhance effect of noise on the energy transduction of molecular machinery. The energy transduction is enhanced with the increase of relative amplitude of the limit-cycle oscillation in polymer chain. And noise can enlarge the relative amplitude through a mechanism of stochastic resonance (SR). In the simulation, two
Zhiwei Wang, Zhonghuai Hou, Houwen Xin
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Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo.

Cancer research, 2001
The protein transduction domain (PTD) embedded in the HIV TAT protein (amino acids 47-57) has been shown to successfully mediate the introduction of heterologous peptides and proteins in excess of Mr 100,000 into mammalian cells in vitro and in vivo. We report here that the modeled structure of the TAT PTD is a strong amphipathic helix. On the basis of
A, Ho, S R, Schwarze, S J, Mermelstein, G, Waksman, S F, Dowdy   +4 more
openaire   +1 more source