Results 81 to 90 of about 145,799 (355)

Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice [PDF]

, 2006
Recombinant adenovirus (rAd)-mediated apoE gene transfer to the liver of apoE(-/-) mice is anti-atherogenic. However, first generation rAd vectors were associated with immune clearance of transduced hepatocytes, while an improved [E1(-), E3(-) polymerase(
Amalfitano, A, Dickson, G, Graham, IR, Harris, JD, Owen, JS   +4 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Analysis of the Effect of Methylation Alterations on Enhancer Activity in Cancer

Guoji laonian yixue zazhi
Objective To analyze and identify the impact of methylation changes on enhancer activity in cancer. Methods Obtain enhancers, transcription factor binding sites, and molecular pathway data from the human enhancer database FANTOM5, methylated DNA binding ...
Yunxiao Xie, Na Ding
doaj   +1 more source

Comparative AAV-eGFP Transgene Expression Using Vector Serotypes 1–9, 7m8, and 8b in Human Pluripotent Stem Cells, RPEs, and Human and Rat Cortical Neurons

Stem Cells International, 2019
Recombinant adeno-associated virus (rAAV), produced from a nonpathogenic parvovirus, has become an increasing popular vector for gene therapy applications in human clinical trials. However, transduction and transgene expression of rAAVs can differ across
Thu T. Duong, James Lim, Vidyullatha Vasireddy, Tyler Papp, Hung Nguyen, Lanfranco Leo, Jieyan Pan, Shangzhen Zhou, H. Isaac Chen, Jean Bennett, Jason A. Mills   +10 more
doaj   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core   +2 more sources

Internal-noise-enhanced signal transduction in neuronal systems [PDF]

Physical Review E, 1997
The ability of a neuron to detect and enhance a weak periodic flow of information within an ``internal-noise'' background has been studied through the mechanism of stochastic resonance. Two kinds of nonlinear synaptic input, a coherent firing of spikes from a number of coupled neurons and an irregular firing of spikes from a single neuron, are ...
Wang, ZD, Wang, W
openaire   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Sox2 Transduction Enhances Cardiovascular Repair Capacity of Blood-Derived Mesoangioblasts [PDF]

Circulation Research, 2010
Rationale : Complementation of pluripotency genes may improve adult stem cell functions. Objectives : Here we show that clonally ...
Koyanagi, M., Iwasaki, M., Rupp, S., Tedesco, F.S., Yoon, C.H., Boeckel, J.N., Trauth, J., Schutz, C., Ohtani, K., Goetz, R., Iekushi, K., Bushoven, P., Momma, S., Mummery, C., Passier, R., Henschler, R., Akintuerk, H., Schranz, D., Urbich, C., Galvez, B.G., Cossu, G., Zeiher, A.M., Dimmeler, S.   +22 more
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Near-field optomechanical transduction enhanced by Raman gain

Optics Express
Raman-gain-enhanced near-field optomechanical transduction between a movable optical cavity and SiN-membrane resonator is demonstrated. The Raman gain compensates for the intrinsic loss of the cavity and amplifies the optomechanical transduction, through which the membrane vibration is sensed using a high-Q whispering-gallery-mode optical cavity ...
Ryoko Sakuma, Motoki Asano, Hiroshi Yamaguchi, Hajime Okamoto   +3 more
openaire   +3 more sources