A Rapid Assessment Approach for Skin Stratum‐Targeted Drug Delivery Systems Using Mass Spectrometry Imaging and Spatial Clustering [PDF]
Small ScienceA novel mass spectrometry imaging (MSI)‐based concept that enables rapid visualization and evaluation of active pharmaceutical ingredient (API) distribution across skin layers following dermal delivery is presented.
Ravit Yakobi Arancibia +9 more
doaj +3 more sources
Design and Characterization of a Transethosome-Based Gel for Cutaneous Administration of Genistein
Journal of NanotechnologyIn this study, lipid nanovesicular systems such as ethosome and transethosome dispersions were studied as potential vehicles for the cutaneous administration of genistein, an isoflavone with antioxidant and chemopreventive properties.
Federico Santamaria +13 more
doaj +4 more sources
Ex Vivo Evaluation of Ethosomes and Transethosomes Applied on Human Skin: A Comparative Study [PDF]
International Journal of Molecular Sciences, 2022 In this study, the transdermal fate of vesicular nanosystems was investigated. Particularly, ethosomes based on phosphatidylcholine 0.9% w/w and transethosomes based on phosphatidylcholine 0.9 or 2.7% w/w plus polysorbate 80 0.3% w/w as an edge activator were prepared and characterized.
Elisabetta Esposito +2 more
exaly +6 more sources
Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis
Royal Society Open Science, 2022 Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis, because of its easy administration, reduced systemic adverse effects and low cost.
Husna Khalid +4 more
doaj +3 more sources
Pharmaceutics, 2022 The present study is aimed to design ethosomes and transethosomes for topical administration of quercetin. To overcome quercetin low bioavailability, scarce solubility and poor permeability that hamper its pharmaceutical use, the drug was loaded in ...
Francesca Ferrara +7 more
doaj +3 more sources
Numerical Optimization of Prednisolone–Tacrolimus Loaded Ultraflexible Transethosomes for Transdermal Delivery Enhancement; Box–Behnken Design, Evaluation, Optimization, and Pharmacokinetic Study [PDF]
Gels, 2023 The aim of the present study is to formulate highly permeable carriers (i.e., transethosomes) for enhancing the delivery of prednisolone combined with tacrolimus for both topical and systemic pathological conditions. A Box–Behnken experimental design was
Munerah M. Alfadhel +3 more
doaj +2 more sources
Enhancing transdermal delivery of retinyl acetate via transethosomes with emphasis on the impact of edge activators on penetration, safety, and efficacy [PDF]
Scientific ReportsTransethosomes are advanced lipid-based nanocarriers engineered to improve the transdermal delivery of therapeutic agents by combining phospholipids, ethanol, and edge activators (EAs), resulting in enhanced membrane fluidity, deformability, and skin ...
Nichaporn Wongsirojkul +7 more
doaj +2 more sources
Physiochemical Characterization of Lipidic Nanoformulations Encapsulating the Antifungal Drug Natamycin [PDF]
NanomaterialsNatamycin is a tetraene polyene that exploits its antifungal properties by irreversibly binding components of fungal cell walls, blocking the growth of infections.
Luigi Talarico +10 more
doaj +2 more sources
Nanotechnology-Based Drug Delivery Systems in the Transdermal Treatment of Melanoma [PDF]
Advanced Pharmaceutical Bulletin, 2023 The incidence rate of melanoma is dramatically increasing worldwide, raising it to the fifth most common cancer in men and the sixth in women currently. Resistance generally occurs to the agents used in chemotherapy; besides their high toxicity destroys ...
Zahra Saeidi +3 more
doaj +2 more sources
Vesicular Carriers for Phytochemical Delivery: A Comprehensive Review of Techniques and Applications [PDF]
PharmaceuticsNatural substances, especially those derived from plants, exhibit a diverse range of therapeutic benefits, such as antioxidant, anti-inflammatory, anticancer, and antimicrobial effects.
Shery Jacob +4 more
doaj +2 more sources