Results 1 to 10 of about 568,858 (297)

G-CSF augments the neuroprotective effect of conditioned medium of dental pulp stem cells against hypoxic neural injury in SH-SY5Y cells [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Dental pulp stem cells (DPSCs) can differentiate into functional neurons and have the potential for cell therapy in neurological diseases.
Farahnaz Ahmadi, Zahra Salmasi, Majid Mojarad, Atieh Eslahi, Zahra Tayarani-Najaran   +4 more
doaj   +1 more source

Inhibition of Small-Conductance, Ca2+-Activated K+ Current by Ondansetron

Frontiers in Pharmacology, 2021
Background: Small-conductance Ca2+-activated K+ channels (SK channels) have been proposed as antiarrhythmic targets for the treatment of atrial fibrillation.
Shuai Guo, Zhenhui Chen, Peng-Sheng Chen, Michael Rubart, Michael Rubart   +4 more
doaj   +1 more source

Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response

Exploration of Targeted Anti-tumor Therapy, 2022
Aim: Gene-based immunotherapy against cancer is limited by low gene transfer efficiency. In the literature, interleukin-12 (IL-12) encoding plasmid associated with sonoporation has been shown to enhance antitumoral activity. Moreover, non-viral carriers
Hai Doan Do, Corinne Marie, Stéphanie Bessoles, Hélène Dhotel, Johanne Seguin, Benoit Larrat, Bich-Thuy Doan, Daniel Scherman, Virginie Escriou, Salima Hacein-Bey-Abina, Nathalie Mignet   +10 more
doaj   +1 more source

Headgroup modification of cholesterol-based cationic lipids: Synthesis, transfection efficiency evaluation, and serum compatibility [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2020
There were two objectives for this study. First, it focused on eight lipids having cholesterol as hydrophobic tails, carbamate linkers, and different polar headgroups.
Chopaka Thongbamrer, Nattisa Niyomtham, Chayutra Chaiwut, Charoen Posa, Nuttapon Apiratikul, Ek Sangvichien, Praneet Opanasopit, Uthai Sakee, Boon-ek Yingyongnarongkul, Widchaya Radchatawedchakoon   +9 more
doaj   +1 more source

ACT001 reduced the expression of programmed cell death protein ligand 1 in glioblastoma cells by inhibiting P65 phosphorylation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To investigate the anti⁃tumoral effect of ACT001, a novel antitumor compound, on the nuclear factor⁃κB (NF⁃κB) pathway and programmed cell death protein ligand 1 (PDL1) expression in U87 glioblastoma cell line.
ZHANG Jin⁃hao, LIU Pei⁃dong, ZHANG Chen, LI Jia⁃bo, REN Xiao, CHEN Lu⁃lu, SUN Jin⁃zhang, WANG Xu⁃ya, ZHANG Liang, YANG Xue⁃jun   +9 more
doaj   +1 more source

Cationic lipid-mediated intracellular delivery of antibodies into live cells

BioTechniques, 2008
The ability to introduce antibodies to live cells opens new insights to a wide range of applications, such as protein intracellular trafficking studies, protein interference studies with blocking antibodies, and live immunolabeling or protein ...
Claire O. Weill, Stéphanie Biri, Patrick Erbacher   +2 more
doaj   +1 more source

Inhibition of Sox2 Expression in the Adult Neural Stem Cell Niche In Vivo by Monocationic-based siRNA Delivery

Molecular Therapy: Nucleic Acids, 2013
RNA interference (RNAi) is a major tool for basic and applied investigations. However, obtaining RNAi data that have physiological significance requires investigation of regulations and therapeutic strategies in appropriate in vivo settings.
Sylvie Remaud, Silvia Alejandra López-Juárez, Anne-Laure Bolcato-Bellemin, Patrick Neuberg, Fabrice Stock, Marie-Elise Bonnet, Rym Ghaddab, Marie Stéphanie Clerget-Froidevaux, Jacqueline Pierre-Simons, Patrick Erbacher, Barbara A Demeneix, Ghislaine Morvan-Dubois   +11 more
doaj   +1 more source

Novel Antitumor Strategy Utilizing a Plasmid Expressing a Mycobacterium tuberculosis Antigen as a “Danger Signal” to Block Immune Escape of Tumor Cells

Pharmaceutics, 2015
Immune escape of tumor cells is one of the main obstacles hindering the effectiveness of cancer immunotherapy. We developed a novel strategy to block immune escape by transfecting tumor cells in vivo with genes of pathogenic antigens from Mycobacterium ...
Yoshiyuki Koyama, Chieko Yoshihara, Tomoko Ito   +2 more
doaj   +1 more source

Gemini Cationic Lipid-Type Nanovectors Suitable for the Transfection of Therapeutic Plasmid DNA Encoding for Pro-Inflammatory Cytokine Interleukin-12

Pharmaceutics, 2021
Ample evidence exists on the role of interleukin-12 (IL-12) in the response against many pathogens, as well as on its remarkable antitumor properties. However, the unexpected toxicity and disappointing results in some clinical trials are prompting the ...
Natalia Sánchez-Arribas, María Martínez-Negro, Clara Aicart-Ramos, Conchita Tros de Ilarduya, Emilio Aicart, Andrés Guerrero-Martínez, Elena Junquera   +6 more
doaj   +1 more source

Lipsome-mediated uptake of exogenous DNA by Sahiwal cattle spermatozoa

Veterinary World, 2012
Aim: To investigate the influence of lipofection treatment and exogenous DNA uptake on the quality of sahiwal cattle spermatozoa. Materials and Methods: Semen collected from sahiwal bulls (n=7) were evaluated separately for color, volume, mass activity ...
Thomas V. Babu, M. D. Pratheesh, N. Anandlaxmi, K. Amarnath   +3 more
doaj   +1 more source