Results 251 to 260 of about 851,785 (340)

DNA-Loaded Nanoparticles Reprogram the Tumor Immune Microenvironment to Treat Brain Tumors. [PDF]

Small Sci
Yang J, Raj D, Slika H, Shahani A, Cheng L, Jain M, Idnani E, Luly KM, Ruchika F, Kraft C, Eberhart C, Brem H, Tyler B, Green JJ, Tzeng SY.   +14 more
europepmc   +1 more source

Proteomic analysis of human glutathione transferase omega (hGSTO1) stable transfection in a 6-hydroxydopamine-induced neuronal cells

, 2018
Jeerang Wongtrakul, Chonticha Saisawang, Benjawan Kumrapich, Jiraprapa Wipasa, Sittiruk Roytrakul, Albert J. Ketterman   +5 more
openalex   +2 more sources

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

Self-Reporting Aggregation-Induced Emission Gene Transfection System via Multivalent Tetrazole-Amine Complexation. [PDF]

JACS Au
Wang S, Li X, Yin C, Zhang Y, Zheng B, Xie S.   +5 more
europepmc   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner. [PDF]

Int J Mol Med
Wang Y, Tian Y, Yao G.
europepmc   +1 more source

83. Topical Tissue Nano Transfection (TNT) Delivery Of VEGFC Prevents Postsurgical Lymphedema

Ganesh Mohan, Shahnur Ahmed, Luci Hulsman, Anish Khan, Miguel D. Jorge, Chandan K. Sen, Mithun Sinha, Aladdin H. Hassanein   +7 more
openalex   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Research progress and application prospect of engineered small extracellular vesicles. [PDF]

Cell Transplant
Zhang H, Chen J, Tang X, Liu X, Li Z.
europepmc   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source