Results 61 to 70 of about 84,478 (232)

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Transforming growth factor-β1 impairs neuropathic pain through pleiotropic effects

Molecular Pain, 2009
Background Understanding the underlying mechanisms of neuropathic pain caused by damage to the peripheral nervous system remains challenging and could lead to significantly improved therapies.
Liu Hong, Haw Alexandra, Shi Xiang, Echeverry Stefania, Zhang Zhong-wei, Zhang Ji   +5 more
doaj   +1 more source

Monolithic 3D‐Integrated All‐Solid Ion‐Gated Carbon Nanotube Transistors With Tunable Ionic Conductance for Multi‐Timescale Reservoir Computing

Advanced Materials, EarlyView.
A dual‐timescale reservoir based on monolithically 3D (M3D)‐integrated CNT solid ion‐gated transistors is demonstrated. Tunable ionic dynamics and pulse‐engineered operation enable linear and symmetric synaptic updates. The M3D‐integrated array achieves robust temporal encoding and accurate classification of moving MNIST sequences, highlighting its ...
Haksoon Jung, Hanbin Cho, Yongwoo Lee, Seunghun Baek, Hyeongjun Kim, Yun Goo Ro, Hyunhyub Ko, Joonki Suh, Yong‐Young Noh, Jimin Kwon   +9 more
wiley   +1 more source

Serum and urinary transforming growth factor beta 1 as biochemical markers in diabetic nephropathy patients

Beni-Suef University Journal of Basic and Applied Sciences, 2014
Diabetic nephropathy is a common complication of diabetes mellitus. Transforming growth factor beta 1 (TGF-β1) is considered to be one of the major cytokines involved in the regulation of extracellular matrix (ECM) synthesis and degradation.
Yehia M. Shaker, Hanan A. Soliman, Elham Ezzat, Nervana S. Hussein, Esmat Ashour, Ashraf Donia, Soad M. Eweida   +6 more
doaj   +1 more source

De Novo Autogenic Engineered Living Functional Materials

Advanced Materials, EarlyView.
A versatile platform for de novo autogenic engineered living materials is presented, leveraging protein mining, computational modeling, and synthetic biology. By reprogramming the Escherichia coli curli machinery with β‐solenoid proteins from non‐model bacteria, macroscopic biomaterials with enhanced mechanical properties, UV‐C irradiation protection ...
Hoda M. Hammad, Seth Swarnadeep, Erin C. Jackson, Nicolas Burns, Hongyu Wang, Harrison Priode, Robert B. Moore, Sanket Deshmukh, Avinash Manjula‐Basavanna, Anna M. Duraj‐Thatte   +9 more
wiley   +1 more source

Experimental Right Ventricular Hypertension Induces Regional β1‐Integrin–Mediated Transduction of Hypertrophic and Profibrotic Right and Left Ventricular Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundDevelopment of right ventricular (RV) hypertension eventually contributes to RV and left ventricular (LV) myocardial fibrosis and dysfunction. The molecular mechanisms are not fully elucidated.
Mei Sun, Ryo Ishii, Kenichi Okumura, Adrienn Krauszman, Siegfried Breitling, Olga Gomez, Aleksander Hinek, Stellar Boo, Boris Hinz, Kim A. Connelly, Wolfgang M. Kuebler, Mark K. Friedberg   +11 more
doaj   +1 more source

Aggregation‐Controlled Vat Dyeing of Meta‐Aramid Fibers: Mechanistic Insights and Suppression of Surface Dye Deposition

Advanced Materials Interfaces, EarlyView.
Supramolecular aggregation governs the interfacial adsorption, diffusion, and fixation of anthraquinone‐based vat dyes in meta‐aramid fibers. By correlating reduction chemistry, aggregate formation, and fiber microstructure, a multiscale mechanism for aggregation‐controlled dyeing is established, providing an effective strategy to suppress surface dye ...
Jisiyuan Qin, Yahui Xia, Shiqi Hu, Yongmin Wu, Mohammad Raza Miah, Ruizhe Lu, Yunhan Tang, Genyang Cao, Sakil Mahmud   +8 more
wiley   +1 more source

Comparison of Transforming Growth Factor-Beta 1 Concentration in Preeclampsia and Normal Pregnancy Women

Indonesian Biomedical Journal, 2017
BACKGROUND: According to the theory of endothelial dysfunction, the pathogenesis of preeclampsia is associated with the imbalance of angiogenic and anti-angiogenic factors.
Yusrawati Yusrawati, Dyka Aidina, Eti Yerizel   +2 more
doaj   +1 more source

LncRNA PlncRNA-1 participates in rheumatoid arthritis by regulating transforming growth factor β1

Autoimmunity, 2020
LncRNA PlncRNA-1(PlncRNA-1) participates in breast cancer by upregulating TGF-β1. It is known that TGF-β1 plays an inhibitory role in the inflammatory responses in rheumatoid arthritis (RA). Therefore, PlncRNA-1 may also participate in RA.
Yang Wang, Guoqing Li, Wentao Guo, Baochao Ji, Aishajiang Aisikeerbayi, Yelborati Boratibai, Li Cao   +6 more
doaj   +1 more source

Molybdenum Disulfide Bilayers Hybridized With Reduced Graphene Oxide Nanosheets for Enhanced Hydrogen Evolution Reaction

Advanced Materials Interfaces, EarlyView.
The integration of reduced graphene oxide nanosheet‐hybridized molybdenum disulfide bilayers to enhance hydrogen evolution reaction capabilities unveils thrilling opportunities for strain engineering, defect manipulation, and sophisticated twist‐angle assemblies with 2D heterostructures.
Bruno Ferreira Brischi, Gabriela Frajtag, João Pedro da Silva Mariano, Laís Fernanda Medeiros Ruela, Gustavo Duarte Verçosa, Camila Desiderio Fernandes, Murilo Santhiago, Letícia Mariê Minatogau Ferro, Leandro Merces   +8 more
wiley   +1 more source