Results 51 to 60 of about 9,299,804 (276)

Measurement of Ferritin and Transforming Growth Factor-β1 Levels in Iraqi Women with Polycystic Ovary Syndrome.

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
      Background: Polycystic ovary syndrome (PCOS) is common heterogeneous disorder syndrome in females, characterized by chronic oligoovulation, polycystic ovary, and hyperandrogenism. This study aimed to the association of ferritin and transforming growth factor- β1 (TGF-β1) levels with insulin resistance, cardiovascular and type 2 diabetes risks ...
Qays A. Mahdi, Shatha A. Adbul Rahman, Fatima M. Mohammed   +2 more
openaire   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Role of the Transforming-Growth-Factor-β1 Gene in Late-Onset Alzheimer's Disease: Implications for the Treatment.

, 2013
Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. LOAD has a complex and largely unknown etiology with strong genetic determinants.
Sabrina Castellano, Raffaele Ferri, NICOLETTI, Ferdinando, M. G. Salluzzo, Paolo Bosco, Filippo Caraci, Filippo Drago, Maria Signorelli, Santo Di Nuovo, DRAGO, Filippo, DI NUOVO, Santo, Bosco P, Signorelli M, CARACI, FILIPPO, Ferri R, Nicoletti F, Salluzzo MG, Castellano S   +17 more
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Transforming growth factor-β1 modulates the expression of vascular endothelial growth factor by osteoblasts

, 1999
Angiogenesis is essential to both normal and pathological bone physiology. Vascular endothelial growth factor (VEGF) has been implicated in angiogenesis, whereas transforming growth factor-β1 (TGF-β1) modulates bone differentiation, matrix formation, and
Babak J. Mehrara, Matthew E. Dudziak, Hikaru Ueno, Joshua A. Greenwald, George K. Gittes, Pierre B. Saadeh, Douglas S. Steinbrech, Jason A. Spector, Michael T. Longaker, Jonathan S. Luchs   +9 more
core   +1 more source

TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma

Biological Research, 2015
BACKGROUND: Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis.
Yijie Chen, Lin Ma, Qian He, Shaobo Zhang, Chenghua Zhang, Wei Jia   +5 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Hyaluronan Facilitates Transforming Growth Factor-β1-dependent Proliferation via CD44 and Epidermal Growth Factor Receptor Interaction

, 2011
Fibroblast proliferation is an early feature of progressive tissue fibrosis and is largely regulated by the cytokine transforming growth factor-β1 (TGF-β1).
Robert Steadman, Dong Dong Luo, Alan Wells, Wells, Alan, Luo, Dong Dong, John Martin, Martin, John, Aled O. Phillips, Meran, Soma, Simpson, Russell M. L., Russell Simpson, Soma Meran, Steadman, Robert, Phillips, Aled Owain   +13 more
core   +1 more source

The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy [PDF]

, 2011
Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of tubulointerstitial fibrosis is epithelial-to-mesenchymal transition ...
Hills, Claire E., Paul E. Squires, Claire E. Hills, Squires, Paul E.   +3 more
core   +1 more source

Constitutive expression of mature transforming growth factor β1 in the liver accelerates hepatocarcinogenesis in transgenic mice

, 1997
Transforming growth factor β-1 (TGF-β1) is a potent inhibitor of hepatocyte growth both in vivo and in vitro. In this study, we analyzed the effects of TGF-β1 on both naturally occurring and diethylnitrosamine- induced hepatocarcinogenesis using single ...
Factor, Valentina M., Kao, Chien Yuan, Jensen, Michael R., Woitach, Joseph T., Thorgeirsson, Snorri S., Santoni-Rugiu, Eric   +5 more
core   +1 more source