TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
Biological Research, 2015 BACKGROUND: Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis.
Yijie Chen +5 more
doaj +1 more source
Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1 [PDF]
, 2011 Background Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth
Hendrik Ungefroren +5 more
core +2 more sources
Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 [PDF]
, 2018 Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is ...
A Clayton +58 more
core +2 more sources
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 Background: Polycystic ovary syndrome (PCOS) is common heterogeneous disorder syndrome in females, characterized by chronic oligoovulation, polycystic ovary, and hyperandrogenism. This study aimed to the association of ferritin and transforming growth factor- β1 (TGF-β1) levels with insulin resistance, cardiovascular and type 2 diabetes risks ...
Qays A. Mahdi +2 more
openaire +1 more source
Transforming growth factor beta-1 (TGF-β1) expression in patients with adenomyosis [PDF]
Revista Brasileira de Ginecologia e ObstetríciaObjective: To compare Transforming growth factor beta-1 (TGF-β1) expression in patients with and without adenomyosis. Methods: A prospective design was performed including 49 patients submitted to hysterectomy.
Andreia Jacobo +4 more
doaj +1 more source
Development of ex vivo organ culture models to mimic human corneal scarring [PDF]
, 2012 PURPOSE: To develop ex vivo organ culture models of human corneal scarring suitable for pharmacological testing and the study of the molecular mechanisms leading to corneal haze after laser surgery or wounding.
Damour, O +6 more
core +1 more source
Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro. [PDF]
, 2011 OBJECTIVE: The origin of the mesenchymal cells responsible for the intimal fibrosis in systemic sclerosis (SSc) has not been fully identified. The present study was undertaken to investigate whether subendothelial mesenchymal cells may emerge through ...
Jimenez, Sergio A., Li, zhaodong
core +2 more sources
ANALYSIS OF THE LEVEL OF TRANSFORMING GROWTH FACTOR β1 IN CHILDREN WITH BRONCHIAL ASTHMA
Мать и дитя в Кузбассе, 2019 Achieving control over the symptoms of the disease is the most important and serious task in the treatment of bronchial asthma. The cause of uncontrolled flow may be the activation of tissue growth factors that trigger the process of remodeling the ...
Наталья Леонидовна Потапова +1 more
doaj
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells
Stem Cell Reports, 2018 Summary: Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) in vivo. We asked whether TGF-β1 controls the cell cycle status of HSCs in vitro to enhance the reconstitution activity.
Xiaofang Wang +14 more
doaj +1 more source
Journal of Immunology Research, 2021 Background and Aims. Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease. We found microRNA-34a (miR-34a), as the downstream gene of p53, was overexpressed in some of fibrogenic diseases.
Ying Pan +3 more
doaj +1 more source