Results 31 to 40 of about 84,478 (232)
Marein alleviates myocardial fibrosis in diabetic mice [PDF]
Jichu yixue yu linchuangObjective To study the effect of marein on myocardial fibrosis in diabetic mice. Methods Ten leptin receptor gene defective heterozygous (db/m) mice aged 5-6 weeks were selected as the control group and 30 diabetic mice with leptin receptor gene ...
TIAN Yating, ZHANG Fang, ZHANG Boxiang, LI Tian
doaj +1 more source
Pathogenetic significance of transforming growth factor β1 in patients with colorectal cancer
Фундаментальная и клиническая медицина, 2022 Aim. We aimed to evaluate levels of transforming growth factor β1 (TGF-β1) in the serum, lymph nodes, and primary tumour in patients with colorectal cancer.Materials and Methods.
A. V. Chetveryakov, V. L. Tsepelev
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Dental Hypotheses, 2013 Introduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after ...
Qian Wei Zhuang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Preparation and functional identification of anti-human transforming growth factor β1 nanobodies [PDF]
Jichu yixue yu linchuang, 2020 Objective To prepare alpaca-derived anti-human TGF-β1 nanobodies with high specificity and high affinity. Methods The eukaryotic expression plasmid cFUGW-TGF-β1 was constructed and transiently transfected into HEK-293T cells to obtain recombinant TGF-β1 ...
WANG Yue, LI Zheng, CHEN Hui, ZHANG Jian-min, HE Wei
doaj
Jurnal Kedokteran Brawijaya, 2013 Meningocele pathogenesis is based on skull defect that occurs since the first three month of fertilization period. Through that defect, mening, cerebrospinal liquid, and cerebral parenchym is protruded. Meningocele can cause by folic aciddeficiency that had proved correlation with TGF-β1 and IGF-I level, both in maternal blood or baby rat’s skull.
openaire +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Majalah Kedokteran Gigi Indonesia, 2019 Periodontal tissue damage requires regenerative material to repair the damage. Platelet-rich plasma (PRP) is known as a regenerative material from blood which contains high level of growth factor that plays a role in wound healing and tissue remodeling ...
Kwartarini Murdiastuti +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source