Results 11 to 20 of about 142,698 (173)

Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing. [PDF]

, 2020
Platelets are a recognised potent source of transforming growth factor-β1 (TGFβ1), a cytokine known to promote wound healing and regeneration by stimulating dermal fibroblast proliferation and extracellular matrix deposition.
Chong, DLW, Holmes, AM, Hughes, S, Labelle, M, Porter, JC, Rodriguez-Justo, M, Scotton, CJ, Trinder, S   +7 more
core   +3 more sources

Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis

Frontiers in Pharmacology, 2020
Idiopathic pulmonary fibrosis is a chronic, progressive, and lethal lung disease of unknown etiology. Antifibrotic drugs, including pirfenidone, are currently used for the treatment of the disease.
Tomohito Okano, Tetsu Kobayashi, Taro Yasuma, Taro Yasuma, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Hajime Fujimoto, Hiroki Nakahara, Yuko Okano, Yuko Okano, Atsuro Takeshita, Atsuro Takeshita, Kota Nishihama, Haruko Saiki, Atsushi Tomaru, Valeria Fridman D’Alessandro, Satoru Ishida, Hiromi Sugimoto, Yoshiyuki Takei, Yoshiyuki Takei, Esteban C. Gabazza, Esteban C. Gabazza   +21 more
doaj   +1 more source

Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis

Haematologica, 2013
Megakaryocytes release platelets into the bloodstream by elongating proplatelets. In this study, we showed that human megakaryocytes constitutively release Transforming Growth Factor β1 and express its receptors.
Stefania Badalucco, Christian Andrea Di Buduo, Rita Campanelli, Isabella Pallotta, Paolo Catarsi, Vittorio Rosti, David L. Kaplan, Giovanni Barosi, Margherita Massa, Alessandra Balduini   +9 more
doaj   +1 more source

Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia

Haematologica, 2018
Mesenchymal stromal cells are involved in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia, but the underlying mechanisms are incompletely understood.
Stefanie Geyh, Manuel Rodríguez-Paredes, Paul Jäger, Annemarie Koch, Felix Bormann, Julian Gutekunst, Christoph Zilkens, Ulrich Germing, Guido Kobbe, Frank Lyko, Rainer Haas, Thomas Schroeder   +11 more
doaj   +1 more source

TGF-β1 on induced osteogenic differentiation of human dermal fibroblast [PDF]

, 2014
PURPOSE:To evaluate the role of transforming growth factor beta 1 (TGF-β1) on the induced osteogenic differentiation of human dermal fibroblasts.METHODS:We performed four groups with cultured dermal fibroblasts according to the culture medium: CONTROL ...
Aloise, Antonio Carlos, Duailibi, Silvio Eduardo, Ferreira, Lydia Masako, Gragnani, Alfredo, Pereira, Max Domingues   +4 more
core   +3 more sources

Transforming growth factor β1 gene polymorphism in postmenopausal osteoporosis

Научно-практическая ревматология, 2009
Objective. Transforming growth factor β1 (TGF β1) prevails among growth factors in bone. It is produced by osteoblasts and is able to hamper osteoclast proliferation, activate and stimulate osteoblasts precursors proliferation and differentiation.
M Y Krylov, K A Maslova, T A Korotkova, N A Toroptsova, O A Nikitinskaya, N V Demin, V A Myakotkin, L I Benevolenskaya   +7 more
doaj   +1 more source

Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy? [PDF]

, 2015
Dupuytren's contracture (DC) is a benign fibro-proliferative disease of the hand causing fibrotic nodules and fascial cords which determine debilitating contracture and deformities of fingers and hands.
Alberto Signore, Caterina Chiappetta, Cira Di Gioia, Elena Pompili, Enrica Bianchi, Francesco S. Pastore, Lia Bardella, Lorenzo Fumagalli, Marco Artico, Samanta Taurone, Susanna Scarpa, Vincenzo Sessa   +11 more
core   +1 more source

Korelasi Antara Transforming Growth Factor -Î’1 Monosit dengan Kebocoran Vaskuler pada Demam Berdarah Dengue

Jurnal Kedokteran Brawijaya, 2013
ABSTRAKSel monosit merupakan target utama infeksi virus Demam Berdarah Dengue (DBD) yang dapat memproduksi faktor vasoaktif yang mempengaruhi fungsi sel endotel dan berperan dalam kebocoran vaskuler. Transforming growth factor beta 1 (TGF-1) merupakan salah satu sitokin yang mempunyai banyak peran dalam patogenesis DBD.
Mohamad Supriatna, Haryson Tondy, Tatty Ermin, Yusrina Istanti, Kisdjamiatun RMD   +4 more
openaire   +1 more source

Transforming growth factor β1, pituitary-specifi c transcriptional factor 1 and insulin-like growth factor I gene polymorphisms in the population of the Poltava clay chicken breed: association with productive traits

Agricultural Science and Practice, 2015
Aim. To investigate the gene polymorphisms of transforming growth factor β1 (TGF-β1), pituitary-specifi c transcriptional factor 1 (PIT-1) and insulin-like growth factor I (IGF-I) in the population of Poltava clay chicken breed, used for egg and meat ...
R. Kulibaba, A. Tereshchenko
doaj   +1 more source

Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion [PDF]

, 2014
Cancer progression is characterized by a complex reciprocity between neoplastic epithelium and adjacent stromal cells. In ductal carcinoma in situ (DCIS) of the breast, both reduced stromal decorin expression and myxoid stroma are correlated with ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Vlieghere, Elly, De Wever, Olivier, Denys, Hannelore, Lambein, Kathleen, Libbrecht, Louis, LIMAME, RIDHA, Van Bockstal, Mieke, Van den Broecke, Rudy, Van Gele, Mireille   +11 more
core   +3 more sources