Results 201 to 210 of about 988,014 (243)

Transforming growth factor‐α

Molecular Reproduction and Development, 1986
Transforming growth factor-α (TGF-α) was first detected in the culture medium of certain retrovirus-transformed cell lines as an activity which binds to the receptor for epidermal growth factor (EGF) and thereby inhibits the binding of EGF. Subsequent examination showed that this factor is made by many other transformed cell lines but not by adult ...
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Transforming growth factors β

British Medical Bulletin, 1989
Since its discovery as a factor able to induce phenotypic transformation with transforming growth factor alpha, transforming growth factor beta (TGF beta) has been found to have unexpectedly widespread and frequently, seemingly paradoxical effects on a variety of cell types.
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Transforming growth factor-? receptors

Cytotechnology, 1989
Transforming growth factor beta (TGF-β) binds specifically and with high affinity to several different cell surface proteins. Low M(r) proteins of 50,000 and 80,000 have been termed type I and type II receptors. Intermediate sized binding components of 115,000-140,000 M(r) and a high binding components of approximately 250,000 M(r) in subunit size have
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Fibronectin‐associated transforming growth factor

Journal of Cellular Physiology, 1987
AbstractWe have studied the ability of fibronectins to induce anchorage‐independent growth of NRK‐49F cells in serum‐free medium. Cells were seeded in soft agar in the presence of various concentrations of plasma fibronectins, and colonies were counted after 10 days.
R A, Fava, D B, McClure
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Epidermal growth factor and transforming growth factor α

Baillière's Clinical Endocrinology and Metabolism, 1991
I have attempted here to outline the basic biochemical knowledge that we have now secured on the EGF family of proteins. In the future we will learn much more about the differential role of EGF versus TGF-alpha, about the physiological significance of amphiregulin, the newest member of this family, and about the roles of TGF-alpha and amphiregulin in ...
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Epidermal growth factor and transforming growth factor α

British Medical Bulletin, 1989
This review describes the discovery and initial characterization of the epidermal growth factors (EGFs) and transforming growth factors alpha (TGF alpha), the biosynthesis and tissue distribution of these molecules and a brief description of the effects of these molecules in culture and animals.
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Growth Factors and Malignant Transformation

1993
In the early 1980’s, approaches aimed at identifying the functions of retroviral oncogenes converged with efforts to investigate normal mitogenic signaling by growth factors. A number of retroviral oncogene products were found to be similar to the protein kinase encoded by v-src product1.
S A, Aaronson   +3 more
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