Results 41 to 50 of about 9,216,194 (230)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Preparation and functional identification of anti-human transforming growth factor β1 nanobodies [PDF]

Jichu yixue yu linchuang, 2020
Objective To prepare alpaca-derived anti-human TGF-β1 nanobodies with high specificity and high affinity. Methods The eukaryotic expression plasmid cFUGW-TGF-β1 was constructed and transiently transfected into HEK-293T cells to obtain recombinant TGF-β1 ...
WANG Yue, LI Zheng, CHEN Hui, ZHANG Jian-min, HE Wei
doaj  

Pathogenetic significance of transforming growth factor β1 in patients with colorectal cancer

Фундаментальная и клиническая медицина, 2022
Aim. We aimed to evaluate levels of transforming growth factor β1 (TGF-β1) in the serum, lymph nodes, and primary tumour in patients with colorectal cancer.Materials and Methods.
A. V. Chetveryakov, V. L. Tsepelev
doaj   +1 more source

Endogenous transforming growth factor β1 suppresses inflammation and promotes survival in adult CNS [PDF]

, 2007
Transforming growth factor β1 (TGFβ1) is a pleiotropic cytokine with potent neurotrophic and immunosuppressive properties that is upregulated after injury, but also expressed in the normal nervous system.
Bauer, K, Koppius, A, Makwana, M, Cuthill, D, Ormsby, I, Jones, LL, Bueringer, D, Friedrichsen, S, Hristova, M, Heuer, H, Bohatschek, M, Doetschman, T, Raivich, G   +12 more
core  

Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells

, 2011
The critical involvement of TGF-β1 (transforming growth factor-β1) in DN (diabetic nephropathy) is well established. However, the role of CTGF (connective tissue growth factor) in regulating the complex interplay of TGF-β1 signalling networks is poorly ...
John Crean, Kavanagh, David H, Kavanagh, David H., Fionnuala Hickey, David H. Kavanagh, Catherine Godson, Godson, Catherine, Noelynn Oliver, O'Donovan, Helen C, Crean, John, Brazil, Derek P, Derek P. Brazil, Finian Martin, Helen C. O'Donovan, Hickey, Fionnuala, Martin, Finian, Oliver, Noelynn, Brazil, Derek P., O'Donovan, Helen C.   +18 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Effect of freeze-drying process of collagen-activated platelet-rich plasma on transforming growth factor-β1 level

Majalah Kedokteran Gigi Indonesia, 2019
Periodontal tissue damage requires regenerative material to repair the damage. Platelet-rich plasma (PRP) is known as a regenerative material from blood which contains high level of growth factor that plays a role in wound healing and tissue remodeling ...
Kwartarini Murdiastuti, Fitri Yuniawati, Dahlia Herawati, Nunuk Purwanti, Dyah Ayu Mira Oktarina   +4 more
doaj   +1 more source

MOESM1 of Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling

, 2015
Supplementary material, approximately 723 KB.
Nicolini, Giuseppina, Forini, Francesca, Kusmic, Claudia, Pitto, Letizia, Mariani, Laura, Iervasi, Giorgio   +5 more
openaire   +1 more source

Role of Transforming Growth Factor-β1 in Invasion and Metastasis in Gastric Carcinoma

, 1999
PURPOSE: Transforming growth factor-beta1 (TGF-β1) is a major modulator of cellular proliferation and extracellular matrix formation. We determined the role of TGF-β1 in invasion and metastasis in gastric cancer.
Yasunori Emi, Yoshihiro Kakeji, Hideo Baba, Yoshihiko Maehara, Akira Kabashima, Shunji Kohnoe, Akihiro Watanabe, Keizo Sugimachi, Kohei Akazawa   +8 more
core   +1 more source

Effects of 530 nm monochromatic light on basic fibroblast growth factor and transforming growth factor-β1 expression in Müller cells [PDF]

, 2015
AIM: To expose rat retinal Müller cells to 530 nm monochromatic light and investigate the influence of varying light illumination times on basic fibroblast growth factor (bFGF) and transforming growth factor-β1 (TGF-β1) expression.METHODS: Three groups ...
Xin-Yi Fu, Zheng-Tai Sun, Wei Xia, Xiao-Feng Zhang, Lei Zhong, Ying-Ming Wang, Jing Xia   +6 more
core   +1 more source