Results 41 to 50 of about 142,802 (274)

Integrin control of the transforming growth factor-β pathway in glioblastoma [PDF]

, 2017
Transforming growth factor-β is a central mediator of the malignant phenotype of glioblastoma, the most common and malignant form of intrinsic brain tumours.
Goodman, Simon L., Hasenbach, Kathy, Maurer, Gabriele, Moch, Holger, Roth, Patrick, Schraml, Peter, Silginer, Manuela, Tabatabai, Ghazaleh, Thies, Svenja, Tritschler, Isabel, Weller, Michael   +10 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Effect of freeze-drying process of collagen-activated platelet-rich plasma on transforming growth factor-β1 level

Majalah Kedokteran Gigi Indonesia, 2019
Periodontal tissue damage requires regenerative material to repair the damage. Platelet-rich plasma (PRP) is known as a regenerative material from blood which contains high level of growth factor that plays a role in wound healing and tissue remodeling ...
Kwartarini Murdiastuti, Fitri Yuniawati, Dahlia Herawati, Nunuk Purwanti, Dyah Ayu Mira Oktarina   +4 more
doaj   +1 more source

Possible Consequences for TGF-β1 Signaling [PDF]

, 2017
Glycosaminoglycans are known to bind biological mediators thereby modulating their biological activity. Sulfated hyaluronans (sHA) were reported to strongly interact with transforming growth factor (TGF)-β1 leading to impaired bioactivity in ...
Koehler, Linda, Köhling, Sebastian, Moeller, Stephanie, Rademann, Jörg, Rother, Sandra, Samsonov, Sergey, Vogel, Sarah   +6 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Preparation and functional identification of anti-human transforming growth factor β1 nanobodies [PDF]

Jichu yixue yu linchuang, 2020
Objective To prepare alpaca-derived anti-human TGF-β1 nanobodies with high specificity and high affinity. Methods The eukaryotic expression plasmid cFUGW-TGF-β1 was constructed and transiently transfected into HEK-293T cells to obtain recombinant TGF-β1 ...
WANG Yue, LI Zheng, CHEN Hui, ZHANG Jian-min, HE Wei
doaj  

Endogenous transforming growth factor β1 suppresses inflammation and promotes survival in adult CNS [PDF]

, 2007
Transforming growth factor β1 (TGFβ1) is a pleiotropic cytokine with potent neurotrophic and immunosuppressive properties that is upregulated after injury, but also expressed in the normal nervous system.
Bauer, K, Bohatschek, M, Bueringer, D, Cuthill, D, Doetschman, T, Friedrichsen, S, Heuer, H, Hristova, M, Jones, LL, Koppius, A, Makwana, M, Ormsby, I, Raivich, G   +12 more
core  

EGF and TGF-β1 effects on thyroid function [PDF]

, 2011
Normal epithelial thyroid cells in culture are inhibited by TGF-β1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-β responsiveness could be due to a reduced expression of TGF-β receptors, as
Gabriella Mincione, Maria Carmela Di Marcantonio, Chiara Tarantelli, D'INZEO, SONIA, NICOLUSSI, Arianna, NARDI, Francesco, Caterina Francesca Donini, COPPA, Anna   +7 more
core   +2 more sources

MOESM1 of Transforming Growth Factor-β1 Downregulates Vascular Endothelial Growth Factor-D Expression in Human Lung Fibroblasts via the Jun NH2-Terminal Kinase Signaling Pathway

, 2014
Supplementary material, approximately 700 KB.
Cui, Ye, Osorio, Juan, Risquez, Cristobal, Wang, Hao, Shi, Ying, Gochuico, Bernadette, Morse, Danielle, Rosas, Ivan, El-Chemaly, Souheil   +8 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source