Results 31 to 40 of about 84,530 (234)

Additional file 1: of P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression

, 2016
Supplementary information containing Table S1. presenting primer sequences used for real-time PCR, and Table S2. presenting the characterization of epithelial to myofibroblast/ myofibroblast-like cell transdifferentiation in 36 articles. (PDF 487 kb)
Li, Haisheng, Yao, Zhihui, He, Weifeng, Gao, Hongyan, Bai, Yang, Yang, Sisi, Zhang, Lu, Zhan, Rixing, Tan, Jianglin, Zhou, Junyi, Takata, Masao, Wu, Jun, Luo, Gaoxing   +12 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Marein alleviates myocardial fibrosis in diabetic mice [PDF]

Jichu yixue yu linchuang
Objective To study the effect of marein on myocardial fibrosis in diabetic mice. Methods Ten leptin receptor gene defective heterozygous (db/m) mice aged 5-6 weeks were selected as the control group and 30 diabetic mice with leptin receptor gene ...
TIAN Yating, ZHANG Fang, ZHANG Boxiang, LI Tian
doaj   +1 more source

Pathogenetic significance of transforming growth factor β1 in patients with colorectal cancer

Фундаментальная и клиническая медицина, 2022
Aim. We aimed to evaluate levels of transforming growth factor β1 (TGF-β1) in the serum, lymph nodes, and primary tumour in patients with colorectal cancer.Materials and Methods.
A. V. Chetveryakov, V. L. Tsepelev
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis?

Dental Hypotheses, 2013
Introduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after ...
Qian Wei Zhuang, Zhi Yuan Zhang, Guang Long Liu, Shui Ting Fu, Yue He   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Preparation and functional identification of anti-human transforming growth factor β1 nanobodies [PDF]

Jichu yixue yu linchuang, 2020
Objective To prepare alpaca-derived anti-human TGF-β1 nanobodies with high specificity and high affinity. Methods The eukaryotic expression plasmid cFUGW-TGF-β1 was constructed and transiently transfected into HEK-293T cells to obtain recombinant TGF-β1 ...
WANG Yue, LI Zheng, CHEN Hui, ZHANG Jian-min, HE Wei
doaj  

MOESM1 of Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling

, 2015
Supplementary material, approximately 723 KB.
Nicolini, Giuseppina, Forini, Francesca, Kusmic, Claudia, Pitto, Letizia, Mariani, Laura, Iervasi, Giorgio   +5 more
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source