Results 11 to 20 of about 84,530 (234)

Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis

Frontiers in Pharmacology, 2020
Idiopathic pulmonary fibrosis is a chronic, progressive, and lethal lung disease of unknown etiology. Antifibrotic drugs, including pirfenidone, are currently used for the treatment of the disease.
Tomohito Okano, Tetsu Kobayashi, Taro Yasuma, Taro Yasuma, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Hajime Fujimoto, Hiroki Nakahara, Yuko Okano, Yuko Okano, Atsuro Takeshita, Atsuro Takeshita, Kota Nishihama, Haruko Saiki, Atsushi Tomaru, Valeria Fridman D’Alessandro, Satoru Ishida, Hiromi Sugimoto, Yoshiyuki Takei, Yoshiyuki Takei, Esteban C. Gabazza, Esteban C. Gabazza   +21 more
doaj   +1 more source

Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia

Haematologica, 2018
Mesenchymal stromal cells are involved in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia, but the underlying mechanisms are incompletely understood.
Stefanie Geyh, Manuel Rodríguez-Paredes, Paul Jäger, Annemarie Koch, Felix Bormann, Julian Gutekunst, Christoph Zilkens, Ulrich Germing, Guido Kobbe, Frank Lyko, Rainer Haas, Thomas Schroeder   +11 more
doaj   +1 more source

Role of transforming growth factor-β1 in breast carcinogenesis [PDF]

Archive of Oncology, 2006
The main objective of this presentation is to review current knowledge regarding molecular mechanisms of Transforming Growth Factor-β1(TGF-ß1) action in breast carcinogenesis.
Ivanović Vesna, Krtolica Koviljka, Krajnović Milena, Dimitrijević Bogomir   +3 more
doaj   +1 more source

Korelasi Antara Transforming Growth Factor -Î’1 Monosit dengan Kebocoran Vaskuler pada Demam Berdarah Dengue

Jurnal Kedokteran Brawijaya, 2013
ABSTRAKSel monosit merupakan target utama infeksi virus Demam Berdarah Dengue (DBD) yang dapat memproduksi faktor vasoaktif yang mempengaruhi fungsi sel endotel dan berperan dalam kebocoran vaskuler. Transforming growth factor beta 1 (TGF-1) merupakan salah satu sitokin yang mempunyai banyak peran dalam patogenesis DBD.
Mohamad Supriatna, Haryson Tondy, Tatty Ermin, Yusrina Istanti, Kisdjamiatun RMD   +4 more
openaire   +1 more source

Transforming growth factor β1 gene polymorphism in postmenopausal osteoporosis

Научно-практическая ревматология, 2009
Objective. Transforming growth factor β1 (TGF β1) prevails among growth factors in bone. It is produced by osteoblasts and is able to hamper osteoclast proliferation, activate and stimulate osteoblasts precursors proliferation and differentiation.
M Y Krylov, K A Maslova, T A Korotkova, N A Toroptsova, O A Nikitinskaya, N V Demin, V A Myakotkin, L I Benevolenskaya   +7 more
doaj   +1 more source

Transforming growth factor β1, pituitary-specifi c transcriptional factor 1 and insulin-like growth factor I gene polymorphisms in the population of the Poltava clay chicken breed: association with productive traits

Agricultural Science and Practice, 2015
Aim. To investigate the gene polymorphisms of transforming growth factor β1 (TGF-β1), pituitary-specifi c transcriptional factor 1 (PIT-1) and insulin-like growth factor I (IGF-I) in the population of Poltava clay chicken breed, used for egg and meat ...
R. Kulibaba, A. Tereshchenko
doaj   +1 more source

Evaluation of rs1982073 polymorphism of transforming growth factor-β1 in glioblastoma

Journal of Research in Medical Sciences, 2019
Background: Glioblastoma (GBM) is the most common and invasive form of primary malignant brain tumors, with a survival rate of about 1 year. Transforming growth factor-β1 (TGF- β 1) plays a very important role in tissue homeostasis and cancers.
Yasaman Sadeghi, Pouya Tabatabaei Irani, Laleh Rafiee, Mohamadhasan Tajadini, Alireza Amouheidari, Shaghayegh Haghjooy Javanmard   +5 more
doaj   +1 more source

Hubungan Kadar Transforming Growth Factor-Beta 1 (TGF-β1) Urin dengan Proteinuria pada Anak Sindrom Nefrotik Resisten Steroid

Jurnal Kedokteran Brawijaya, 2013
 Transforming  Growth  Factor-Beta  1  (TGF-β1)  menjadi  perantara  fibrosis  interstisial,  atrofi  tubular,  dan  kerusakan gromelurus ginjal. Proteinuria menunjukkan prognosis yang buruk pada  sindroma nefrotik. Terdapat kecenderungan persisten proteinuria pada sindroma nefrotik resisten steroid.
Prasetya Ismail P, L Enggar Fitri, Krisni Subandijah   +2 more
openaire   +2 more sources

Effect of Sini decoction on angiotensin II, transforming growth factor β1 and connective tissue growth factor in rats with myocardial fibrosis-induced banding of the abdominal aorta

Journal of Traditional Chinese Medicine, 2018
To investigate the effect of Sini decoction on rats with myocardial fibrosis induced by banding the abdominal aorta, and explore the mechanism underlying its actions on angiotensin ¢ò(Ang ¢ò), transforming growth factor-¦Â1 (TGF-¦Â1) and connective tissue growth factor (CTGF).Forty-eight male Sprague-Dawley rats were randomly divided into sham ...
Yueping, Shi, Chunxiao, Liu, Jianli, Zhai   +2 more
openaire   +2 more sources

Kadar Transforming Growth Factor β-1 Urin pada Berbagai Keadaan Proteinuria

Sari Pediatri, 2019
Latar belakang. Proteinuria masif pada sindrom nefrotik (SN) akan menginduksi suatu rentetan reaksi biologis di tubular proksimal. Reaksi ini mengaktivasi peptida vasoaktif dan produksi sitokin, seperti TGF-β1.
Partini P. Trihono, Husein Alatas, Taralan Tambunan, Sudigdo Sastroasmoro   +3 more
doaj   +1 more source