Results 51 to 60 of about 142,802 (274)

Effects of TGF-β1 and IGF-1 on proliferation of human nucleus pulposus cells in medium with different serum concentrations [PDF]

, 2006
Background The low proliferative viability of human nucleus pulposus(NP) cells is considered as a cause of intervertebral discs degeneration. Growth factors, such as TGF-β1 and IGF-1, have been implicated in cell proliferation and matrix synthesis ...
Rongfeng Zhang, Dike Ruan, Chao Zhang, Le Maitre, HA Horner, Delatte, K Chaipinyo, WC Wu, S Sobajima, ST Pattison, BE Loveland, YL Joon, YB Tan, M Alini, Gu Shouming, Y Hiraki, R Osada, HE Gruber, K Takegami, H An   +19 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma

Biological Research, 2015
BACKGROUND: Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis.
Yijie Chen, Lin Ma, Qian He, Shaobo Zhang, Chenghua Zhang, Wei Jia   +5 more
doaj   +1 more source

Biological activity differences between TGF-β1 and TGF-β3 correlate with differences in the rigidity and arrangement of their component monomers [PDF]

, 2014
[Image: see text] TGF-β1, -β2, and -β3 are small, secreted signaling proteins. They share 71–80% sequence identity and signal through the same receptors, yet the isoform-specific null mice have distinctive phenotypes and are inviable.
Andrew P. Hinck, Archer S. J., Archer S. J., Baardsnes J., Baker S. M., Bandyopadhyay B., Biernacka A., Bocharov E. V., Bocharov E. V., Cheifetz S., Daopin S., Deep S., Delaglio F., Eghbalnia H. R., Freedberg D. I., Gato A., Goddard T. D., Groppe J., Grutter C., Grzesiek S., Grzesiek S., Hall B. E., Hart P. J., Hinck A. P., Hinck A. P., Huang T., Kay L. E., Kay L. E., Kulkarni A. B., Liu Q., Loeys B. L., Lopez-Casillas F., Marley J., Massague J., Massague J., Massague J., Mendoza V., Mittl P. R., Moustakas A., Munoz V., Munoz V., Nilsen-Hamilton M., Pellaud J., Proetzel G., Qian S. W., Radaev S., Sanford L. P., Schlunegger M. P., Schor S. L., Seth L. Schor, Shah M., Shi Y., Shull M. M., Tao Huang, Taya Y., Tudela C., Wittekind M., Wrana J. L., Wrana J. L., Yang L. T., Zou Z., Zuniga J. E.   +61 more
core   +2 more sources

Additional file 1: of Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1

, 2016
Additional methods.
Hahn, Jennifer, McFarland, Kevin, Combs, Kelly, Supp, Dorothy   +3 more
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Vascular reactivity modulation by exposure to serum from patients with Marfan syndrome in healthy rat aortic rings

Heliyon
Introduction: Marfan syndrome is a rare disease in which different metabolic pathways and immune mediators such as transforming growth factor β1, interleukins and metalloproteinases participate.
María Elena Soto, Linaloe Manzano-Pech, Omar Gonzalez-Marcos, Verónica Guarner-Lans, Elizabeth Soria-Castro, Ricardo Gamboa, Claudia Huesca, Giovanny Fuentevilla-Álvarez, Israel Pérez-Torres   +8 more
doaj   +1 more source

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1 [PDF]

, 2011
Background Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth
Hendrik Ungefroren, Stephanie Groth, Susanne Sebens, Hendrik Lehnert, Frank Gieseler, Fred Fändrich   +5 more
core   +2 more sources

Additional file 1: of P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression

, 2016
Supplementary information containing Table S1. presenting primer sequences used for real-time PCR, and Table S2. presenting the characterization of epithelial to myofibroblast/ myofibroblast-like cell transdifferentiation in 36 articles. (PDF 487 kb)
Haisheng Li, Zhihui Yao, Weifeng He, Hongyan Gao, Bai, Yang, Sisi Yang, Zhang, Lu, Rixing Zhan, Jianglin Tan, Junyi Zhou, Takata, Masao, Wu, Jun, Gaoxing Luo   +12 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source