Results 51 to 60 of about 84,530 (234)

Transforming growth factor beta-1 (TGF-β1) expression in patients with adenomyosis [PDF]

Revista Brasileira de Ginecologia e Obstetrícia
Objective: To compare Transforming growth factor beta-1 (TGF-β1) expression in patients with and without adenomyosis. Methods: A prospective design was performed including 49 patients submitted to hysterectomy.
Andreia Jacobo, Renata Fogaça Borges, Carlos Augusto Bastos de Souza, Vanessa Krebs Genro, João Sabino Cunha-Filho   +4 more
doaj   +1 more source

Creep‐Induced Microstructural Evolution in an A2‐B2 Superalloy

Advanced Engineering Materials, EarlyView.
A 27.3Ta‐27.3Mo‐27.3Ti‐8Cr‐10Al (at.%) refractory high‐entropy alloy with precipitation‐strengthened A2‐B2 microstructure was studied by creep tests at 1030°C, which demonstrate a transition in deformation mechanisms in the range of 100–150 MPa applied stress. This is associated with changes in dislocation–precipitate interactions. Relevant deformation
Liu Yang, Aparajita Pramanik, Sandipan Sen, Shubhashis Dixit, Marcel Muench, R. J. Vikram, Daniel Schliephake, Yolita M. Eggeler, Ankur Chauhan, Martin Heilmaier, Alexander Kauffmann   +10 more
wiley   +1 more source

TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells

Stem Cell Reports, 2018
Summary: Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) in vivo. We asked whether TGF-β1 controls the cell cycle status of HSCs in vitro to enhance the reconstitution activity.
Xiaofang Wang, Fang Dong, Sen Zhang, Wanzhu Yang, Wenying Yu, Zhao Wang, Shanshan Zhang, Jinhong Wang, Shihui Ma, Peng Wu, Yun Gao, Ji Dong, Fuchou Tang, Tao Cheng, Hideo Ema   +14 more
doaj   +1 more source

External and Internal Cracking Caused by Heat Treatment in Laser Powder Bed Fusion‐Fabricated Inconel 738LC Components

Advanced Engineering Materials, EarlyView.
Manufacturing problems such as heat treatment‐induced cracking hinder the widespread application of the laser powder bed fusion (LPBF) process to superalloys. In this study, cracks in the LPBF components of Inconel 738LC superalloy are characterized after heat treatment at various temperature ranges, revealing two distinct cracking behaviors.
Kosuke Kuwabara, Masahiro Kusano, Ayako Ikeda, Toshio Osada, Makoto Watanabe   +4 more
wiley   +1 more source

Curcumin inhibits TGF-β1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts

Journal of the Formosan Medical Association, 2018
Background/Purpose: Many fibrotic processes are associated with an increased level of transforming growth factor-β1 (TGF-β1). TGF-β1 can increase synthesis of matrix proteins and enhance secretion of protease inhibitors, resulting in matrix accumulation.
Jung-Tsu Chen, Chen-Ying Wang, Min-Huey Chen   +2 more
doaj   +1 more source

MicroRNA-34a Promotes EMT and Liver Fibrosis in Primary Biliary Cholangitis by Regulating TGF-β1/smad Pathway

Journal of Immunology Research, 2021
Background and Aims. Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease. We found microRNA-34a (miR-34a), as the downstream gene of p53, was overexpressed in some of fibrogenic diseases.
Ying Pan, Jing Wang, Lan He, Fengchun Zhang   +3 more
doaj   +1 more source

One‐Step Curcumin‐Mediated Multiphoton Lithography for Bioactive 3D Scaffolds

Advanced Functional Materials, EarlyView.
Curcumin‐mediated multiphoton lithography enables one‐step fabrication of highly architected complex gelatin methacryloyl scaffolds by exploiting curcumin as a multifunctional bioactive photoinitiator. The resulting 3D structures support mesenchymal stem cell adhesion, proliferation, and migration, while exhibiting dual antibacterial activity through ...
Myrto Charitaki, Michalis Stavrou, Chrysanthi Pinelopi Apostolidou, Elmina Kabouraki, David Gray, Anna Mitraki, Anthi Ranella, Maria Farsari   +7 more
wiley   +1 more source

Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways

Cellular Physiology and Biochemistry, 2015
Background/Aims: Severe acute lung injury (ALI) often develops into acute respiratory distress syndrome (ARDS). Previous studies have shown that platelet-derived growth factor (PDGF) and transforming growth factor β1 (TGFβ1) participate in the ...
Xingqi Deng, Kun Jin, Yanyan Li, Wei Gu, Mei Liu, Ling Zhou   +5 more
doaj   +1 more source

A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses

Advanced Healthcare Materials, EarlyView.
This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang, Charles‐Francois Latchoumane, Avi Chopra, Md Marzan Sarkar, Chunki Kim, Nathan Gonsalves, Hsueh‐Fu Wu, John C. Sentmanat, Alan Liu, Isha Mhatre‐Winters, Aditya Mishra, Andrei G. Fedorov, Jay M. Patel, Nadja Zeltner, Steven L. Stice, Jason R. Richardson, Lohitash Karumbaiah   +16 more
wiley   +1 more source

Intraventricular administration of hepatocyte growth factor treats mouse communicating hydrocephalus induced by transforming growth factor β1

Neurobiology of Disease, 2006
Communicating hydrocephalus may occur spontaneously in elderly patients or occur as a complication of meningitis or intracranial hemorrhage, typically as a result of fibrosis along the route of cerebrospinal fluid (CSF) flow.
Tsuyoshi Tada, Hua Zhan, Yuichiro Tanaka, Kazuhiro Hongo, Kunio Matsumoto, Toshikazu Nakamura   +5 more
doaj   +1 more source