Results 131 to 140 of about 6,113,361 (250)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gene expression profiling in DLBCL primary clinical samples

, 2016
Accession Number: GSE74266 Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array Organism: Homo sapiens Published on 2016-10-05 Summary: Gene expression profiling was performed for 28 DLBCL primary clinical samples and assignment
Aalborg University Hospital, Dybkær, Karen; id_orcid, The Faculty of Engineering and Science (ENG), Klinik Kirurgi og Kræftbehandling, Department of Clinical Medicine, Schmitz, Alexander, Ettrup, Marianne Schmidt, Bilgrau, Anders Ellern, Klinik Diagnostik, Klinik Medicin, Bøgsted, Martin; id_orcid, Jørgensen, Laura Krogh, The Faculty of Medicine, Ranjbar, Benyamin, Aarhus University, Johnsen, Hans Erik, Primo, Maria Nascimento, Marques, Sara Correia, Department of Pathology, Blodsygdomme (Hæmatologi) [Klinik Medicin], Falgreen, Steffen, Laursen, Maria Bach, Bødker, Julie Støve; id_orcid, Mikkelsen, Jacob Giehm, Aalborg University, Department of Mathematical Sciences   +25 more
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Agroinfiltration Mediated Scalable Transient Gene Expression in Genome Edited Crop Plants. [PDF]

Int J Mol Sci, 2021
Kaur M, Manchanda P, Kalia A, Ahmed FK, Nepovimova E, Kuca K, Abd-Elsalam KA.   +6 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression

, 2011
In any given cell, thousands of genes are expressed and work in concert to ensure the cell's function, fitness, and survival. Each gene, in turn, must be expressed at the proper time and in the proper amounts to ensure the appropriate functional outcome.
L. T. MacNeil, A. J. M. Walhout, MacNeil, Lesley T., Albertha J.M. Walhout, Walhout, Albertha J M, Lesley T. MacNeil   +5 more
core   +1 more source

Increasing Transfection Efficiency of Lipoplexes by Modulating Complexation Solution for Transient Gene Expression. [PDF]

Int J Mol Sci, 2021
Kim J, Kim JY, Kim H, Kim E, Park S, Ryu KH, Lee EG.   +6 more
europepmc   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Expanding the application of a UV-visible reporter for transient gene expression and stable transformation in plants. [PDF]

Hortic Res, 2021
Yuan G, Lu H, Tang D, Hassan MM, Li Y, Chen JG, Tuskan GA, Yang X.   +7 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Transcriptional regulation of the human c-myc gene [PDF]

, 1988
The involvement of c-myc in the genesis of animal neoplasia is now well documented for several systems. In order to define the precise role played by the myc gene in tumorigenesis, a better understanding of the normal regulation of myc expression is ...
Wilkie, N M, Whitelaw, B, Lang, J C, Talbot, S   +3 more
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