Results 91 to 100 of about 11,254,715 (215)

Transient receptor potential channels in bladder function

, 2013
The transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions.
Avelino, A., Cruz, C., Frias, B., Cruz, F., Boudes, M., de Ridder, D., Charrua, Ana   +6 more
core  

TRP Channels as Potential Drug Targets

, 2018
The transient receptor potential (TRP) superfamily of channels comprises a diverse group of cation channels. Four TRP channel subunits coassemble to form functional homo- or heterotetramers that pass sodium, calcium, or both in the inward direction ...
Magdalene M. Moran
core   +1 more source

Allosterism and structure in thermally activated transient receptor potential channels

, 2022
S.371-398The molecular sensors that mediate temperature changes in living organisms are a large family of proteins known as thermosensitive transient receptor potential (TRP) ion channels.
Miño-Galaz, G., Latorre, R., Diaz-Franulic, I., Poblete, H., González, C.   +4 more
core   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Editorial: Transient receptor potential (TRP) ion channels in non-excitable cells

Frontiers in Physiology, 2023
Mustafa Nazıroğlu, Mustafa Nazıroğlu, Beatrice Mihaela Radu, Dana Cucu   +3 more
doaj   +1 more source

TRP channels in mammalian hearing loss

Frontiers in Molecular Neuroscience
Hearing loss, a common sensory disorder, significantly diminishes quality of life and can stem from diverse causes, including genetic predispositions, aging, noise exposure, and ototoxic medications.
Zhidong Zhang, Baoshan Wang
doaj   +1 more source

Structure of the full-length TRPV2 channel by cryo-EM

Nature Communications, 2016
Transient receptor potential (TRP) proteins are Ca2+-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation
Kevin W. Huynh, Matthew R. Cohen, Jiansen Jiang, Amrita Samanta, David T. Lodowski, Z. Hong Zhou, Vera Y. Moiseenkova-Bell   +6 more
doaj   +1 more source

The Diacylglycerol Analogs OAG and DOG Differentially Affect Primary Events of Pheromone Transduction in the Hawkmoth Manduca sexta in a Zeitgebertime-Dependent Manner Apparently Targeting TRP Channels

Frontiers in Cellular Neuroscience, 2018
For the hawkmoth Manduca sexta accumulating evidence suggests that pheromone transduction acts via a metabotropic signal transduction cascade, with G-protein-dependent phospholipase C (PLC) activations generating diacylglycerol (DAG) and inositol ...
Petra Gawalek, Monika Stengl
doaj   +1 more source

Thermosensory Transient Receptor Potential Ion Channels and Asthma

, 2021
Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology.
Juliy M. Perelman, Denis E. Naumov, Tatyana P. Novgorodtseva, Tatyana A. Gvozdenko, Oxana Yu. Kytikova, Yulia K. Denisenko   +5 more
core   +1 more source

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

Pest Management Science, EarlyView.
This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti, Eric L. Patterson, Todd A. Gaines, Aldo Merotto   +3 more
wiley   +1 more source