Results 21 to 30 of about 30,248 (242)
Frontiers in Molecular Biosciences, 2023 Introduction: Calcium flux is the master second messenger that influences the proliferation–apoptosis balance. The ability of calcium flux alterations to reduce cell growth makes ion channels interesting targets for therapy.
Federica Maggi +7 more
doaj +1 more source
Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]
PLoS ONE, 2011 Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder +21 more
doaj +1 more source
Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models
Channels, 2023 Cardiovascular disease, especially heart failure (HF) is the leading cause of death in patients with diabetes. Individuals with diabetes are prone to a special type of cardiomyopathy called diabetic cardiomyopathy (DCM), which cannot be explained by ...
Jiaqi Bao +4 more
doaj +1 more source
TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]
, 2020 Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core +1 more source
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin [PDF]
The Journal of Physiology, 2005 Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+ permeable non‐selective cation channel activated by physical and chemical stimuli. Resiniferatoxin (RTX), an ultrapotent agonist of TRPV1, is under investigation for treatment of urinary bladder hyper‐reflexia and chronic pain conditions.
Manish, Raisinghani +2 more
openaire +2 more sources
Vascular Expression of Transient Receptor Potential Vanilloid 1 (TRPV1) [PDF]
Journal of Histochemistry & Cytochemistry, 2015 Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was funded by the British
Sand, Claire A +2 more
openaire +3 more sources
Dexmedetomidine modulates transient receptor potential vanilloid subtype 1
Biochemical and Biophysical Research Communications, 2020 Dexmedetomidine, a highly selective alpha-2 adrenergic receptor agonist and novel sedative drug with minimal respiratory suppression, have shown anti-nociceptive activity in various pain models by poorly understood mechanisms. Because alpha-2 adrenergic receptor is co-localized with TRPV1 polymodal nociceptive receptor in dorsal root ganglion neurons ...
Byeong-Min Lee +6 more
openaire +3 more sources
The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not [PDF]
Pharmacological Reviews, 2009 The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel as pain therapeutics has revealed that these compounds cause hyperthermia in humans. This undesirable on-target side effect has triggered a surge of interest in the role of TRPV1 in thermoregulation and revived the hypothesis that TRPV1 channels serve as ...
Andrej A, Romanovsky +8 more
openaire +2 more sources
Sensitization of Transient Receptor Potential Vanilloid 1 by the Prokineticin Receptor Agonist Bv8 [PDF]
The Journal of Neuroscience, 2006 Small mammalian proteins called the prokineticins [prokineticin 1 (PK1) and PK2] and two corresponding G-protein-coupled receptors [prokineticin receptor 1 (PKR1) and PKR2] have been identified recently, but the physiological role of the PK/PKR system remains mostly unexplored. Bv8, a protein extracted from frog skin, is a convenient and potent agonist
V. Vellani +6 more
openaire +3 more sources
The Journal of Headache and Pain, 2021 Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker +7 more
doaj +1 more source