Results 111 to 120 of about 23,801 (234)

Taste genomics and type 2 diabetes mellitus: a systematic qualitative meta-synthesis [PDF]

Exploration of Endocrine and Metabolic Diseases
Background: Emerging evidence suggests that genetic variations in taste receptor genes may influence dietary behaviors, energy homeostasis, and metabolic risk, contributing to type 2 diabetes mellitus (T2DM) pathogenesis.
Vishnu Shivam, Sahana Kannan, Vishnu Harish   +2 more
doaj   +1 more source

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis [PDF]

, 2014
The question of how the neural and immune systems interact in host defence is important, integrating a system that senses the whole body with one that protects.
Bakri M. Assas, Jaleel A. Miyan, Joanne I. Pennock   +2 more
core   +2 more sources

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Capsazepine, a Transient Receptor Potential Vanilloid Type 1 (TRPV1) Antagonist, Attenuates Antinociceptive Effect of CB1 Receptor Agonist, WIN55,212-2, in the Rat Nucleus Cuneiformis

Basic and Clinical Neuroscience, 2011
Introduction: Nucleus cuneiformis (NCF), as part of descending pain inhibitory system, cooperates with periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) in supraspinal modulation of pain. Cannabinoids have analgesic effects in the PAG, RVM
Abbas Haghparast, Mohammad Ebrahimzadeh, Zahra Taslimil, Asghar Parvishan   +3 more
doaj   +2 more sources

Interaction Between the Cannabinoid and Vanilloid Systems on Anxiety in Male Rats

Basic and Clinical Neuroscience, 2017
Introduction: Previous studies have shown that the cannabinoid system is involved in anxiety.In addition, transient receptor potential vanilloid type-1 (TRPV1) channels are new targets for the development of anxiolytics.
Nafiseh Faraji, Alireza Komaki, Iraj Salehi   +2 more
doaj  

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia

Frontiers in Veterinary Science, 2019
Growing evidence indicates cannabinoid receptors as potential therapeutic targets for chronic pain. Consequently, there is an increasing interest in developing cannabinoid receptor agonists for treating human and veterinary pain. To better understand the
Roberto Chiocchetti, Giorgia Galiazzo, Claudio Tagliavia, Agnese Stanzani, Fiorella Giancola, Marika Menchetti, Gianfranco Militerno, Chiara Bernardini, Monica Forni, Luciana Mandrioli   +9 more
doaj   +1 more source

L-Carnitine Suppresses Transient Receptor Potential Vanilloid Type 1 Activation in Human Corneal Epithelial Cells. [PDF]

Int J Mol Sci, 2023
Lucius A, Chhatwal S, Chhatwal S, Valtink M, Reinach PS, Li A, Pleyer U, Mergler S.   +7 more
europepmc   +1 more source

Role of the transient receptor potential vanilloid type 1 channel in renal inflammation induced by lipopolysaccharide in mice.

Am J Physiol Regul Integr Comp Physiol, 2013
To determine the role of the transient receptor potential vanilloid type 1 (TRPV1) channel in the regulation of renal inflammation, lipopolysaccharide (LPS, 3 mg/kg) was intraperitoneally injected into wild-type (WT) and TRPV1-null mutant (TRPV1−/−) mice.
Wang Y, Wang DH.
europepmc   +4 more sources

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source