Results 101 to 110 of about 23,801 (234)

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain [PDF]

, 2013
Objectives Blockade of transient receptor potential vanilloid 1 (TRPV1) with systemic antagonists attenuates osteoarthritis (OA) pain behaviour in rat models, but on-target-mediated hyperthermia has halted clinical trials.
A Wong, Arden, Arendt-Nielsen, Ayoub, B N Okine, Brederson, Brenn, Brown, C Bullock, Caterina, Chu, Clayton, Crawford, Creamer, D A Barrett, D A Walsh, D F McWilliams, D R Sagar, De Schepper, Donaldson, Dunham, Engler, Fernandes, Fernihough, G J Hathway, Garami, Gavva, Gavva, Guo, Guzman, Haywood, Hendiani, Hinton, Honore, Honore, J Huang, J J Burston, J Turner, K Paton, Kelly, Kelly, Kelly, Planells-Cases, R J Chapman, Romanovsky, S Kelly, S Woodhams, Sagar, Schuelert, Schuelert, Steiner, Suokas, Swanson, Szolcsanyi, V Chapman, Valdes, Wong, Xie, Zhang   +58 more
core   +5 more sources

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice

Frontiers in Pharmacology, 2017
Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA) within several pain-related brain structures.
Diego C. Mascarenhas, Diego C. Mascarenhas, Karina S. Gomes, Tatiani Sorregotti, Tatiani Sorregotti, Ricardo L. Nunes-de-Souza, Ricardo L. Nunes-de-Souza   +6 more
doaj   +1 more source

Non‐Pharmacological Interventions for Cough in Patients With Lung Cancer: A Systematic Review and Meta‐Analysis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Background Cough, a prevalent and debilitating symptom of lung cancer, remains poorly managed. Accumulating evidence on non‐pharmacological interventions for lung cancer cough necessitates systematic evaluation to assess their efficacy. Aim To synthesise evidence on non‐pharmacological interventions for managing cough in lung cancer patients ...
Mengyao Cao, Xueyan Cheng, Victor Ho‐fun Lee, Chia‐Chin Lin, Denise Shuk Ting Cheung   +4 more
wiley   +1 more source

Capsaicin: beyond TRPV1

Frontiers in Nutrition
Capsaicin, the chili-pungent compound, has a peculiar chemical structure that allows it to impact mammalian physiology. Besides its classical effects through activating the Transient Receptor Potential Vanilloid type 1 (TRPV1), growing experimental ...
Rebeca Juárez-Contreras, Rebeca Juárez-Contreras, Edgardo Mota-Carrillo, Edgardo Mota-Carrillo, Angelica Piedra-Ramírez, Angelica Piedra-Ramírez, Daniel Farías-Sánchez, Daniel Farías-Sánchez, Ricardo González-Ramírez, Ricardo González-Ramírez, Sara Luz Morales-Lázaro, Sara Luz Morales-Lázaro   +11 more
doaj   +1 more source

Uncoupling protein 2: a key player and a potential therapeutic target in vascular diseases [PDF]

, 2017
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative ...
Forte, Maurizio, Migliarino, Serena, Perelli, Marika, Pierelli, Giorgia, Rubattu, Speranza, Stanzione, Rosita, Volpe, Massimo   +6 more
core   +2 more sources

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Capsaicin for neuropathic pain: linking traditional medicine and molecular biology [PDF]

, 2012
Capsaicin has long been used as a traditional medicine to treat pain and, recently, its mechanism of analgesic action has been discovered. This review article documents the clinical development of capsaicin to demonstrate that pharmacognosy still has a ...
Haanpää, Maija, Treede, Rolf-Detlef
core   +1 more source

Supplementary Figure 1 from Transient Receptor Potential Type Vanilloid 1 Suppresses Skin Carcinogenesis

, 2023
Supplementary Figure 1 from Transient Receptor Potential Type Vanilloid 1 Suppresses Skin ...
Zigang Dong, Ke Yao, Wei-Ya Ma, Marna E. Ericson, Feng Zhu, Duo Zheng, Yong-Yeon Cho, Ann M. Bode   +7 more
openaire   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source