Results 81 to 90 of about 23,801 (234)

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. [PDF]

, 2017
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety ...
Yang, Fan, Zheng, Jie
core   +2 more sources

Hell's Itch: A Self‐Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a severely distressing dermatological condition characterized by the onset of incessant itching and intolerable pain 2–3 days post‐sunburn. It is underdiagnosed and underreported, and no definitive management framework has yet been developed.
Kai Peter Moors, Willem I. Visser
wiley   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Peripheral Mediators of Colorectal Nociception and Sensitization [PDF]

, 2012
Several ion channels are thought to facilitate colorectal afferent neuron sensitization, which contributes to abdominal pain in irritable bowel syndrome (IBS).
Kiyatkin, Michael E
core  

Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat [PDF]

, 2016
Background: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic ...
A Dickenson, A Hasani, A Morita, A Szabo, A Szallasi, A Tóth, AC Barrett, D Melck, D Ursu, DR Sagar, FN McNamara, G Woolfe, GY Wong, H Xu, J Hoffmann, JB Davis, JR Ghilardi, JR Saper, L Bach-Rojecky, L Petrocellis De, L Yang, M Alsalem, M Cantillon, M Caterina, M Tominaga, M-G Lee, MDM Wallace, MJ Caterina, MJ Gunthorpe, N Kedei, NR Gavva, P Anand, PA Koplas, PE Micevych, PJ Millns, R Docherty, RM Lindsay, S Diamond, S Mandadi, SR Eid, T Christoph, T Rosenbaum, V Marzo Di, Z Vogel   +43 more
core   +2 more sources

Data from Transient Receptor Potential Type Vanilloid 1 Suppresses Skin Carcinogenesis

, 2023
<div>Abstract<p>Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief. However, TRPV1 is a widely expressed protein whose function might be critical in various nonneuronal physiologic conditions.
Zigang Dong, Ke Yao, Wei-Ya Ma, Marna E. Ericson, Feng Zhu, Duo Zheng, Yong-Yeon Cho, Ann M. Bode   +7 more
openaire   +1 more source

Deletion of Transient Receptor Potential Vanilloid Type 1 Receptors Exaggerates Renal Damage in Deoxycorticosterone Acetate-Salt Hypertension [PDF]

Hypertension, 2008
To determine whether the transient receptor potential vanilloid type 1 (TRPV1) channel provides protection against hypertension-induced renal damage, hypertension was induced by uninephrectomy and by giving deoxycorticosterone acetate (DOCA)-salt in wild-type (WT) and TRPV1-null mutant (TRPV1 −/−
Youping, Wang, Dagmar, Babánková, Jie, Huang, Greg M, Swain, Donna H, Wang   +4 more
openaire   +2 more sources

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

TRPV1 Antagonists as Novel Anti-Diabetic Agents: Regulation of Oral Glucose Tolerance and Insulin Secretion Through Reduction of Low-Grade Inflammation?

Medical Sciences, 2019
With a global prevalence among adults over 18 years of age approaching 9%, Type 2 diabetes mellitus (T2DM) has reached pandemic proportions and represents a major unmet medical need. To date, no disease modifying treatment is available for T2DM patients.
Dorte X. Gram, Josefine Fribo, Istvan Nagy, Carsten Gotfredsen, Ana Charrua, John B. Hansen, Anker J. Hansen, Arpad Szallasi   +7 more
doaj   +1 more source

A Closer Look at Anandamide Interaction With TRPV1

Frontiers in Molecular Biosciences, 2020
The transient receptor potential subfamily vanilloid type 1 ion channel (TRPV1), located in the peripheral nervous system has been implicated in the perception of pain and possesses the ability to be modulated by various cannabinoid ligands.
Chante Muller, Diane L. Lynch, Dow P. Hurst, Patricia H. Reggio   +3 more
doaj   +1 more source