Results 101 to 110 of about 1,651,715 (287)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Towards the effects of translators' emotional intelligence and anxiety on their translation quality. [PDF]
Heliyon, 2023 Qiu G.
europepmc +1 more source
Evaluation of Hindi to Punjabi Machine Translation System [PDF]
, 2009 Machine Translation in India is relatively young. The earliest efforts date from the late 80s and early 90s. The success of every system is judged from its evaluation experimental results.
Goyal, Vishal, SINGH LEHAL, Gurpreet
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A retrospective view on the promise on machine translation for Bahasa Melayu-English [PDF]
, 2010 Research and development activities for machine translation systems from English language to others are more progressive than vice versa. It has been more than 30 years since the machine translation was introduced and yet a Malay language or Bahasa ...
Jamaludin, Zulikha +2 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
TECHNIQUES AND QUALITY OF 'CIVIL WAR: WHOSE SIDE ARE YOU ON?' COMIC TRANSLATION
Leksema: Jurnal Bahasa dan Sastra, 2018 The objectives of this study were to know the translation techniques and the assessment translation quality of Marvel comic series entitled Civil War: Whose Side Are You? (Part 1 and 2) in terms of accuracy, acceptability, and readability.
Rifqi Hanif Barezzi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source