Results 51 to 60 of about 258,884 (313)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

ANALISIS SIRKUMSTAN PADA BUKU CERITA ANAK THE 7 HABBITS OF HAPPY KIDS KARYA SEAN COVEY DAN TERJEMAHANNYA (Kajian Terjemahan dengan Pendekatan Systemic Functional Linguistics)

open access: yesLingua: Jurnal Bahasa, Sastra dan Pengajarannya, 2018
This research investigated the form and types of circumstances,  translation techniques, translation quality of circumstances, and the impact of translation techniques towards the form, types and translation quality of circumstances in bilingual kids ...
Husna Imro’athush Sholihah   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Techniques of Translating Adele’s 25 Album into Indonesian and The Naturalness Quality

open access: yesRainbow: Journal of Literature, Linguistics and Culture, 2019
This research focuses on analyzing the use of translation techniques and the naturalness of the translated lyrics. The objectives of the study were to investigate the translation techniques used to translate song lyrics and to identify the naturalness in
Edi Hartono, Issy Yuliasri
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Discursive Creation Technique of English to Indonesian Subtitle in Harry Potter: the Chamber of Secrets Movie

open access: yesLingual, 2019
The purpose of this paper is to analyze the used of discursive creation technique of English to Indonesian subtitle in Harry Potter: The Chamber of Secrets movie. This research is descriptive qualitative method.
Lilik Istiqomah   +2 more
doaj  

The Concept of Equivalence and Translation Techniques in the Poststructuralists’ Theories of Translation

open access: yesRespectus Philologicus, 2015
This article studies the development of the translation theories in the second half of the twentieth century, a period during which significant theoretical contributions were made in translation circles. These contributions had a profound impact on the practice of translation.
openaire   +4 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

METHODS AND TECHNIQUES OF TRANSLATION

open access: yes, 2022
When describing the translation process, researchers use such concepts as method, technique, method, each of which has its own content. A method is not an activity, not a system of actions, but a psychological operation that realizes an action. It is possible to go from one language to another to express an already formulated thought, to re-name the ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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