Results 91 to 100 of about 10,052 (217)

Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease [PDF]

, 2013
Blood transfusion has been identified as a source of human-to-human transmission of variant Creutzfeldt–Jakob disease. Three cases of variant Creutzfeldt–Jakob disease have been identified following red cell transfusions from donors who subsequently ...
Abigail B. Diack, Bishop, Brown, Bruce, Bruce, Bruce, Clarke, Diack, Diane L. Ritchie, Fraser, Garske, Head, Hill, Hilton, HPA, James W. Ironside, Jean C. Manson, Llewelyn, Matthew T. Bishop, Peden, Pocchiari, Prusiner, Ritchie, Robert G. Will, Wadsworth, Will, Wroe   +26 more
core   +1 more source

Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells. [PDF]

Int J Mol Sci, 2022
Heumüller SE, Hornberger AC, Hebestreit AS, Hossinger A, Vorberg IM.   +4 more
europepmc   +1 more source

High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age [PDF]

, 2009
Following a severe outbreak of clinical scrapie in 2006–2007, a large dairy goat herd was culled and 200 animals were selected for post-mortem examinations in order to ascertain the prevalence of infection, the effect of age, breed and PRNP genotype on
Dawson, M., Goldmann, W., Gonzalez, L., Hawkins, S. A., Hope, J., Jeffrey, M., Konold, T., Martin, S., Ortiz-Pelaez, A., Phelan, L., Saunders, G., Siso, S., Stewart, P., Windl, O.   +13 more
core   +3 more sources

Phenotype shift from atypical scrapie to CH1641 following experimental transmission in sheep.

PLoS ONE, 2015
The interactions of host and infecting strain in ovine transmissible spongiform encephalopathies are known to be complex, and have a profound effect on the resulting phenotype of disease.
Marion M Simmons, S Jo Moore, Richard Lockey, Melanie J Chaplin, Timm Konold, Christopher Vickery, John Spiropoulos   +6 more
doaj   +1 more source

Molecular Typing of Protease-Resistant Prion Protein in Transmissible Spongiform Encephalopathies of Small Ruminants, France, 2002–2009

Emerging Infectious Diseases, 2011
The agent that causes bovine spongiform encephalopathy (BSE) may be infecting small ruminants, which could have serious implications for human health. To distinguish BSE from scrapie and to examine the molecular characteristics of the protease-resistant ...
Johann Vulin, Anne-Gaëlle Biacabe, Géraldine Cazeau, Didier Calavas, Thierry Baron   +4 more
doaj   +1 more source

Transmissible spongiform encephalopathies in Australia

Communicable Diseases Intelligence, 2001
The Australian National Creutzfeldt-Jakob Disease Registry (ANCJDR) commenced surveillance in September 1993 as part of the Commonwealth's response to 4 cases of pituitary hormone (gonadotrophin)-associated Creutzfeldt-Jakob disease (CJD). With the passage of time, the Registry has become responsible for ascertaining all human transmissible spongiform ...
A, Boyd, A, Fletcher, J S, Lee, V, Lewis, C L, Masters, S J, Collins   +5 more
openaire   +2 more sources

PrPSc detection in formalin-fixed paraffin-embedded tissue by ELISA [PDF]

, 2011
Background Formalin-fixed paraffin-embedded tissue is regularly employed in the diagnosis of transmissible spongiform encephalopathies (TSE) by immunohistochemistry (IHC), the standard by which all other TSE diagnostic protocols are judged.
Eric M Nicholson, Justin J Greenlee, Amir N Hamir   +2 more
core   +2 more sources

Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

Animal, 2016
Scrapie is a naturally occurring transmissible spongiform encephalopathy in sheep and goat. It has been known for ~250 years and is characterised by the accumulation of an abnormal isoform of a host-encoded prion protein that leads to progressive ...
L. Curcio, C. Sebastiani, P. Di Lorenzo, E. Lasagna, M. Biagetti   +4 more
doaj   +1 more source

Clinical perspectives of emerging pathogens in bleeding disorders. [PDF]

, 2006
As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe ...
Bozzette, Samuel, Diamond, Michael, Koerper, Marion A, Kulkarni, Roshni, Ludlam, Christopher A, Powderly, William G, Ritchie, Bruce, Siegel, Jamie, Simmonds, Peter, Stanley, Samuel, Tapper, Michael L, von Depka, Mario   +11 more
core   +1 more source

Transmissible Spongiform Encephalopathies in Humans [PDF]

Annual Review of Microbiology, 1999
▪ Abstract  Creutzfeldt-Jakob disease (CJD), the first transmissible spongiform encephalopathy (TSE) to be described in humans, occurs in a sporadic, familial, or iatrogenic form. Other TSEs in humans, shown to be associated with specific prion protein gene mutations, have been reported in different parts of the world.
openaire   +2 more sources