Results 91 to 100 of about 6,019 (214)

Transmissible Spongiform Encephalopathies [PDF]

, 2012
Neuronal death represents the primary pathology of neurodegenerative diseases such as Alzheimer's and Parkinson’s disease and Amyotrophic Lateral Sclerosis. These diseases usually present with a slow onset and a chronic progression. Various regions of the brain, spinal cord, or peripheral nerves may be affected, leading to functional impairment and ...
Glaucia N. M. Hajj, Tiago G., Michele C., Marilene H.   +3 more
openaire   +1 more source

Small critical RNAs in the scrapie agent

, 2009
Unconventional infectious agents cause transmissible spongiform encephalopathy (TSE) diseases including scrapie and bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease in humans. The protein only hypothesis claims that the TSE
Marie-Madeleine Ruchoux, Jean-Philippe Deslys, Nicolas Vignier, Pierre Lebon, Jean-Guy Fournier, Sophie Freire, Emmanuel Comoy, Steve Simoneau   +7 more
core  

The crystal structure of the globular domain of sheep prion protein

, 2004
The prion protein PrP is a naturally occurring polypeptide that becomes transformed from a normal conformation to that of an aggregated form, characteristic of pathological states in fatal transmissible spongiform conditions such as Creutzfeld–Jacob ...
Vasisht N, Whyte, SM, Dodson EJ, Vasisht, N, Gill, A.C., Whyte, S.M., Dodson, G.G., Whyte, S M, Vasisht, N., Bayley, P M, Verma, C., Verma C, Gill, A C, Bayley, PM, Bayley, P.M., Whyte SM, Haire LF, Gill AC, Gill, AC, Bayley PM, Dodson, EJ, Haire, L.F., Dodson, GG, Dodson, E.J., Haire, L F, Verma, C, Haire, LF, Dodson, E J, Dodson, G G   +28 more
core   +1 more source

Prion remains infectious after passage through digestive system of American crows (Corvus brachyrhynchos).

PLoS ONE, 2012
Avian scavengers, such as American crows (Corvus brachyrhynchos), have potential to translocate infectious agents (prions) of transmissible spongiform encephalopathy (TSE) diseases including chronic wasting disease, scrapie, and bovine spongiform ...
Kurt C VerCauteren, John L Pilon, Paul B Nash, Gregory E Phillips, Justin W Fischer   +4 more
doaj   +1 more source

Overexpression of mouse prion protein in transgenic mice causes a non-transmissible spongiform encephalopathy. [PDF]

Sci Rep, 2022
Jackson GS, Linehan J, Brandner S, Asante EA, Wadsworth JDF, Collinge J.   +5 more
europepmc   +1 more source

Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells. [PDF]

Int J Mol Sci, 2022
Heumüller SE, Hornberger AC, Hebestreit AS, Hossinger A, Vorberg IM.   +4 more
europepmc   +1 more source

Phenotype shift from atypical scrapie to CH1641 following experimental transmission in sheep.

PLoS ONE, 2015
The interactions of host and infecting strain in ovine transmissible spongiform encephalopathies are known to be complex, and have a profound effect on the resulting phenotype of disease.
Marion M Simmons, S Jo Moore, Richard Lockey, Melanie J Chaplin, Timm Konold, Christopher Vickery, John Spiropoulos   +6 more
doaj   +1 more source

Molecular Typing of Protease-Resistant Prion Protein in Transmissible Spongiform Encephalopathies of Small Ruminants, France, 2002–2009

Emerging Infectious Diseases, 2011
The agent that causes bovine spongiform encephalopathy (BSE) may be infecting small ruminants, which could have serious implications for human health. To distinguish BSE from scrapie and to examine the molecular characteristics of the protease-resistant ...
Johann Vulin, Anne-Gaëlle Biacabe, Géraldine Cazeau, Didier Calavas, Thierry Baron   +4 more
doaj   +1 more source

Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks

, 2011
Susceptibility to scrapie, a transmissible spongiform encephalopathy in sheep, is modulated by the genetic make-up of the sheep. Scrapie control policies, based on selecting animals of resistant genotype for breeding, have recently been adopted by the ...
van Roermund, H.J.W., Bas Engel, Lucien JM van Keulen, Roermund, H.J.W., van, Gonnie Nodelijk, van Roermund Herman JW, Vellema, P., Herman JW van Roermund, Vellema Piet, Engel, B., Thomas J Hagenaars, Nodelijk Gonnie, Engel Bas, Keulen, L.J.M., van, Hagenaars, T.H.J., van Keulen, L.J.M., Nodelijk, G., Piet Vellema, Hagenaars Thomas J, van Keulen Lucien JM   +19 more
core   +1 more source

Human α2β1HI CD133+VE epithelial prostate stem cells express low levels of active androgen receptor [PDF]

, 2012
Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated.
Ryan-Munden, C.A., Leung, Hing, Hepburn, A.C., Heer, R., Leung, H.Y., Ryan-Munden, Claudia, Wilson, L., Laura Wilson, Coffey, Kelly, Claudia A Ryan-Munden, Pal, Deepali, Coffey, K., Craig N Robson, Robson, C.N., Williamson, Stuart, Pal, D., Hepburn, Anastasia, Robson, Craig, Heer, Rakesh, Hing Y Leung, Leung, H.L., Deepali Pal, Williamson, S.C., Kelly Coffey, Wilson, Laura, Stuart C Williamson, Rakesh Heer, Tang, Yao Liang, Anastasia C Hepburn   +28 more
core   +1 more source