Optimal Acceptance of Incompatible Kidneys [PDF]
Journal of the Operational Research Society 2025, 2022 Incompatibility between patient and donor is a major barrier in kidney transplantation (KT). The increasing shortage of kidney donors has driven the development of desensitization techniques to overcome this immunological challenge. Compared with compatible KT, patients undergoing incompatible KTs are more likely to experience rejection, infection ...
arxiv +1 more source
Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022 Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers +7 more
wiley +1 more source
A Transformer-Based Deep Learning Approach for Fairly Predicting Post-Liver Transplant Risk Factors [PDF]
J Biomed Inform. 2024 Jan;149:104545, 2023 Liver transplantation is a life-saving procedure for patients with end-stage liver disease. There are two main challenges in liver transplant: finding the best matching patient for a donor and ensuring transplant equity among different subpopulations. The current MELD scoring system evaluates a patient's mortality risk if not receiving an organ within ...
arxiv +1 more source
Skin Immunology and Rejection in VCA and Organ Transplantation
Current Transplantation Reports, 2020 Skin provides a window into the health of an individual. Using transplanted skin as a monitor can provide a powerful tool for surveillance of rejection in a transplant.
D. Leonard +4 more
semanticscholar +1 more source
A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD
JCI Insight, 2021 Graft-versus-host disease (GVHD) is a pathological process caused by an exaggerated donor lymphocyte response to host antigens after allogeneic hematopoietic cell transplantation (allo-HCT).
M. Hanief Sofi +12 more
doaj +1 more source
Unraveling the Role of Allo-Antibodies and Transplant Injury. [PDF]
, 2016 Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both ...
Matsuda, Yoshiko, Sarwal, Minnie M
core +9 more sources
Transplant: Immunology and treatment of rejection [PDF]
American Journal of Kidney Diseases, 2004 Connie L, Davis, Donald E, Hricik
openaire +4 more sources
Transplantation tolerance from a historical perspective [PDF]
, 2001 Although transplantation immunology as a distinctive field began with the development of experimental models that showed the feasibility of bone marrow transplantation, organ engraftment was accomplished first in humans, and was thought for many years to
Starzl, TE, Zinkernagel, RM
core +1 more source
Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey. [PDF]
, 2020 Primary Immune Regulatory Disorders (PIRD) are an expanding group of diseases caused by gene defects in several different immune pathways, such as regulatory T cell function.
Allenspach, Eric J +59 more
core +1 more source
The role of HLA-DP mismatches and donor specific HLA-DP antibodies in kidney transplantation : a case series [PDF]
, 2021 BACKGROUND: The impact of HLA-DP mismatches on renal allograft outcome is still poorly understood and is suggested to be less than that of the other HLA loci.
Abramowicz, D +9 more
core +2 more sources