Results 31 to 40 of about 2,033 (187)

Transplante isogênico de ilhotas de Langerhans no fígado de ratos: metodologia para separação e purificação das ilhotas de Langerhans Isogenic islet transplantation on the rat liver: Method for isolation and purification of the rat islets

Arquivos de Gastroenterologia, 2000
A maior indicação do transplante de pâncreas ou de ilhotas de Langerhans é o diabetes mellitus do tipo I. O processo deve suprir as necessidades de insulina mantendo os níveis glicêmicos dentro da normalidade.
Eleazar CHAIB, Apostolos PAPALOIS, Ingrid G. M. BRONS, Roy Y. CALNE   +3 more
doaj   +1 more source

Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF‐α‐Smurf1‐Akt‐mTOR‐P70S6K pathway

Journal of Cellular and Molecular Medicine, Volume 23, Issue 8, Page 5390-5402, August 2019., 2019
Abstract Allograft interstitial fibrosis was characterized by massive extracellular matrix deposition caused by activated fibroblasts and myofibroblasts. Epithelial‐mesenchymal transition (EMT) is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis.
Jiajun Zhou, Hong Cheng, Zijie Wang, Hao Chen, Chuanjian Suo, Hengcheng Zhang, Jiayi Zhang, Yanhao Yang, Liang Geng, Ming Gu, Ruoyun Tan   +10 more
wiley   +1 more source

Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation.

Kidney International, 2011
Carbon monoxide (CO) can provide beneficial antiapoptotic and anti-inflammatory effects in the context of ischemia–reperfusion injury (IRI). Here we tested the ability of pretreating the kidney donor with carbon monoxide-releasing molecules (CORM) to ...
Y. Caumartin, J. Stephen, Jian P. Deng, D. Lian, Z. Lan, Weihua Liu, B. Garcia, A. Jevnikar, Hao Wang, G. Cepinskas, P. Luke   +10 more
semanticscholar   +2 more sources

Renal Allograft Rejection: Noninvasive Ultrasound‐ and MRI‐Based Diagnostics

Contrast Media &Molecular Imaging, Volume 2019, Issue 1, 2019., 2019
To date, allogeneic kidney transplantation remains the best available therapeutic option for patients with end‐stage renal disease regarding overall survival and quality of life. Despite the advancements in immunosuppressive drugs and protocols, episodes of acute allograft rejection, a sterile inflammatory process, continue to endanger allograft ...
Ulrich Jehn, Katharina Schuette-Nuetgen, Dominik Kentrup, Verena Hoerr, Stefan Reuter, Sarah Ohrndorf   +5 more
wiley   +1 more source

Exogenous Lipocalin 2 Ameliorates Acute Rejection in a Mouse Model of Renal Transplantation

American Journal of Transplantation, Volume 16, Issue 3, Page 808-820, March 2016., 2016
Abstract Lipocalin 2 (Lcn2) is rapidly produced by damaged nephron epithelia and is one of the most promising new markers of renal injury, delayed graft function and acute allograft rejection (AR); however, the functional importance of Lcn2 in renal transplantation is largely unknown. To understand the role of Lcn2 in renal AR, kidneys from Balb/c mice
M. I. Ashraf, H. G. Schwelberger, K. A. Brendel, J. Feurle, J. Andrassy, K. Kotsch, H. Regele, J. Pratschke, H. T. Maier, F. Aigner   +9 more
wiley   +1 more source

Extracellular Vesicles from MSC Modulate the Immune Response to Renal Allografts in a MHC Disparate Rat Model

Stem Cells International, Volume 2015, Issue 1, 2015., 2015
Application of mesenchymal stromal cells (MSC) has been proposed for solid organ transplantation based on their potent immunomodulatory effects. Since side effects from the injection of large cells cannot be excluded, the hypothesis rises that extracellular vesicles (EV) may cause immunomodulatory effects comparable to MSC without additional side ...
M. Koch, A. Lemke, C. Lange, Eva Mezey
wiley   +1 more source

Two Faces of TGF‐Beta1 in Breast Cancer

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Breast cancer (BC) is potentially life‐threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF‐β1 is one of many factors that have
Joanna Magdalena Zarzynska, Arkadiusz Orzechowski   +1 more
wiley   +1 more source

Cellular transplantation of nephrons

, 2005
Cellular transplantation of nephrons. Embryonic renal cellular primordia transplanted into animal hosts undergo nephrogenesis in situ, become vascularized by blood vessels of host origin, exhibit excretory function, and support life in otherwise anephric
Hammerman, Marc R.
core   +1 more source

Immunological Barriers to Stem Cell Therapy in the Central Nervous System

Stem Cells International, Volume 2014, Issue 1, 2014., 2014
The central nervous system is vulnerable to many neurodegenerative disorders such as Alzheimer’s disease that result in the extensive loss of neuronal cells. Stem cells have the ability to differentiate into many types of cells, which make them ideal for treating such disorders.
Gregory E. Tullis, Kathleen Spears, Mark D. Kirk, Donald S. Sakaguchi   +3 more
wiley   +1 more source

IL-10, TGF-β, IL-2, IL-6, IL-17, IL-23, TNF-α, and IFN-γ concentrations in recipient serum and intestinal grafts (S1 and S2 Tables).

, 2014
Cytokine concentrations in the recipient serum and intestinal grafts were measured by ELISA on day 1, 5, 7, and 10 after transplantation. Data are expressed as mean ± SD (p≤0.05 compared with *nontransplanted controls; #isogeneic controls; +allogeneic ...
Wei-Ping Zheng (674857), Zhong-Yang Shen (674859), Chong Don (674858), Ben-Juan Wu (674855), Nan-Nan Fu (674856), Wen Zhang (7555), Yang Yang (45629), Hong-Li Song (674854)   +7 more
core   +1 more source