Results 31 to 40 of about 1,497 (173)
Custodiol-N, the novel cardioplegic solution reduces ischemia/reperfusion injury after cardiopulmonary bypass [PDF]
, 2015 Backgrounds: On the basis of Custodiol preservation and cardioplegic solution a novel cardioplegic solution was developed to improve the postischemic cardiac and endothelial function.
Karck, Matthias +4 more
core +1 more source
Immunological Barriers to Stem Cell Therapy in the Central Nervous System
Stem Cells International, Volume 2014, Issue 1, 2014., 2014 The central nervous system is vulnerable to many neurodegenerative disorders such as Alzheimer’s disease that result in the extensive loss of neuronal cells. Stem cells have the ability to differentiate into many types of cells, which make them ideal for treating such disorders.
Gregory E. Tullis +3 more
wiley +1 more source
Impairment of early fracture healing by skeletal muscle trauma is restored by FK506 [PDF]
, 2017 BACKGROUND: Heightened local inflammation due to muscle trauma or disease is associated with impaired bone regeneration. METHODS: We hypothesized that FK506, an FDA approved immunomodulatory compound with neurotrophic and osteogenic effects, will ...
Corona, Benjamin T. +8 more
core +2 more sources
International Journal of Endocrinology, Volume 2012, Issue 1, 2012., 2012 The complementary role of hyperglycemia and p27kip1 suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27kip1 gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27kip1 protein content in cultured targeting islets was 22% of that in ...
Szu-Tah Chen +5 more
wiley +1 more source
Islet Assessment for Transplantation [PDF]
, 2009 Author Manuscript: 2010 December 1.Purpose of review: There is a critical need for meaningful viability and potency assays that characterize islet preparations for release prior to clinical islet cell transplantation (ICT).
Colton, Clark K. +2 more
core +1 more source
Cell Transplantation, 1996 Intraductal distention of the pancreas with collagenase followed by stationary warm incubation improves the recovery of islets of Langerhans in the rat, but controlled studies are needed for valid comparison with standard isolation methods.
A.M. James Shapiro +3 more
doaj +1 more source
Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts. [PDF]
British Journal of Cancer, 1966 Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts.
Woodruff, M F, Boak, J L
openaire +2 more sources
Osteogenic Small Molecule FK506 for Enhanced Bone Formation in a Rabbit Ankle Fusion Model
Journal of Orthopaedic Research, Volume 43, Issue 10, Page 1805-1812, October 2025.ABSTRACT Non‐union remains a significant complication following ankle fusion procedures, underscoring the need for effective osteogenic adjuvants to improve boney healing and fusion outcomes. This study investigates the osteogenic potential of FK506 (Tacrolimus), both in vitro and in vivo, for enhanced ankle fusion.
Nicholas Huffman +6 more
wiley +1 more source
Advanced Science, Volume 12, Issue 20, May 29, 2025.Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu +19 more
wiley +1 more source
Molecular Medicine Reports, 2018 The present study investigated the effects of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in transplantation-associated arteriosclerosis by observing their expression in transplanted aortas in rats. Allogenic and isogenic abdominal aortic transplantations were performed and grafts were removed from the recipients
Si-Dong, Wei +5 more
openaire +3 more sources