Results 11 to 20 of about 1,497 (173)

Nanotherapeutics in transplantation: How do we get to clinical implementation? [PDF]

Am J Transplant, 2022
Patients undergoing organ transplantation transition from one life‐altering issue (organ dysfunction) to a lifelong commitment—immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the long‐term and ...
Plumblee L, Atkinson C, Jaishankar D, Scott E, Tietjen GT, Nadig SN.   +5 more
europepmc   +2 more sources

Whole‐Genome Sequencing Revealed a Late‐Maturing Isogenic Rice Koshihikari Integrated with Hd16 Gene Derived from an Ise Shrine Mutant

International Journal of Genomics, Volume 2022, Issue 1, 2022., 2022
We identified the key genes controlling the late maturation of the Japonica cultivar Isehikari, which was found at Ise Jingu Shrine and matures 6 days later than Koshihikari. We conducted a genetics‐based approach through this study. First, the latest mature plants, which flowered later than Isehikari, were segregated in the F2 and F3 generations of ...
Motonori Tomita, Ryotaro Tokuyama, Shosuke Matsumoto, Kazuo Ishii, Vijay Gahlaut   +4 more
wiley   +1 more source

A Comprehensive Update of Cerebral Organoids between Applications and Challenges

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
The basic technology of stem cells has been developed and created organoids, which have established a strong interest in regenerative medicine. Different cell types have been used to generate cerebral organoids, which include interneurons and oligodendrocytes (OLs). OLs are fundamental for brain development.
Xiaodong Li, Abdullah Shopit, Jingmin Wang, Sandra Moreno   +3 more
wiley   +1 more source

Cuff Anastomosis of Both Renal Artery and Vein to Minimize Thrombosis: A Novel Method of Kidney Transplantation in Mice

Journal of Investigative Surgery, 2022
Objectives Anastomosis of renal artery and renal vein in mouse models of kidney transplantation is technically challenging. Conventional technique using suture may result in vascular thrombosis.
Yi Yu, Jun Li, Zirong Bi, Chenglin Wu, Shicong Yang, Qifeng Jiang, Ronghai Deng, Qian Fu, Longshan Liu, Changxi Wang   +9 more
doaj   +1 more source

High-dose atorvastatin reduces oxidative stress of ischemia/reperfusion injury after isogeneic kidney transplantation in rats: in vivo, preclinical, case–control, open-label study

Renal Replacement Therapy, 2023
Background Renal ischemia/reperfusion injury is an unavoidable event in transplantation in which free radical-mediated injury determines release of pro-inflammatory cytokines and activation of innate immunity.
Giacomo Cusumano, Edoardo Cola, Gionata Spagnoletti, Anna Severino, Simona Giubilato, Egidio Stigliano, Maria Emiliana Caristo, Gisella Vischini, Giovanna Liuzzo, Maria Paola Salerno, Filippo Crea, Jacopo Romagnoli   +11 more
doaj   +1 more source

In vitro studies on the inhibitory effect of lymphoid cells. II. Antitumor activity of lymphoid cells from spontaneous mammary tumor-bearing mice on the autochthonous primary culture tumor cells [PDF]

, 1971
As a step in the elucidation of human cancer immunity we studied antitumor activity of lymphoid cells by conducting a series of cultures using the primary culture of cells from spontaneous mammary cancers from C3H and RIll mice mixed with autochthonous ...
Ohsugi, Masaki
core   +3 more sources

Tissue typing by unidirectional mixed lymphocyte culture. I. Demonstration of the cumulative effect of non-H-2 antigens in mice by cultured lymphocytes mixed with cell homogenate [PDF]

, 1970
1. The mixed lymphocyte culture test where live lymphocytes of female mice are cultured with supersonicated cell homogenate of isogeneic male mice does not reflect the difference in H-Y histocompatibility antigen alone. 2.
Tsunemitsu, Kensuke
core   +1 more source

Effect in supralethally irradiated rats of granulocyte colony- stimulating factor and lisofylline on hematopoietic reconstitution by syngeneic bone marrow or whole organ passenger leukocytes [PDF]

, 1997
We have previously shown the existence of migratory hematopoietic stem cells in adult solid organs. This study demonstrates that granulocyte colony- stimulating factor (G-CSF) and lisofylline, a phosphatidic acid inhibitor that suppresses hematopoiesis ...
Abdul Rao, Angus W. Thomson, Anthony J. Demetris, Berry, Bociek, Clarke, Fontes, Foster, Foster, Lieschke, Lyman, Masanobu Terakura, Moore, Murase, Murase, Noriko Murase, Qing Ye, Schuening, Singer, Starzl, Tanikawa, Thomas E. Starzl, Toshiki Sakamoto, Uckun   +23 more
core   +1 more source

The glomerular filtration rate of isogeneically transplanted rat kidneys

Kidney International, 1982
The glomerular filtration rate (GFR) was determined in rats with an isogeneic kidney transplant and compared with that of unilaterally nephrectomized rats. Experiments were carried out in adult rats, 3 months of age, weighing approximately 300 g, as well as in juvenile rats, 6 to 8 weeks of age, weighing approximately 170 g.
Provoost, Abraham P., de Keijzer, Marinus H., Kort, Wil J., Wolff, Erik D., Molenaar, Jan C.   +4 more
openaire   +2 more sources

Adipose Tissue-Derived Mesenchymal Stem Cells Increase Skin Allograft Survival and Inhibit Th-17 Immune Response [PDF]

, 2013
Adipose tissue-derived mesenchymal stem cells (ADSC) exhibit immunosuppressive capabilities both in vitro and in vivo. Their use for therapy in the transplant field is attractive as they could render the use of immunosuppressive drugs unnecessary.
Bassi, Ênio José, Câmara, Niels Olsen Saraiva, da Silva, Marina Burgos, de Almeida, Danilo Candido, Larocca, Rafael Assumpção, Moraes-Vieira, Pedro Manoel, Pacheco-Silva, Alvaro, Semedo, Patrícia, Thornley, Thomas   +8 more
core   +5 more sources