Results 11 to 20 of about 1,074 (138)

A Comprehensive Update of Cerebral Organoids between Applications and Challenges

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
The basic technology of stem cells has been developed and created organoids, which have established a strong interest in regenerative medicine. Different cell types have been used to generate cerebral organoids, which include interneurons and oligodendrocytes (OLs). OLs are fundamental for brain development.
Xiaodong Li, Abdullah Shopit, Jingmin Wang, Sandra Moreno   +3 more
wiley   +1 more source

Two Compartment Evaluation of Liver Grafts During Acellular Room Temperature Machine Perfusion (acRTMP) in a Rat Liver Transplant Model

Frontiers in Medicine, 2022
BackgroundSubnormothermic machine perfusion (SNMP) of liver grafts is currently less clinically developed than normothermic and hypothermic approaches, but may have logistical advantages.
Nader Abraham, Min Zhang, Paul Cray, Qimeng Gao, Kannan P. Samy, Ryan Neill, Greta Cywinska, JonCarlo Migaly, Riley Kahan, Arya Pontula, Samantha E. Halpern, Caroline Rush, Jude Penaflor, Samuel J. Kesseli, Madison Krischak, Mingqing Song, Matthew G. Hartwig, Justin J. Pollara, Andrew S. Barbas   +18 more
doaj   +1 more source

High-dose atorvastatin reduces oxidative stress of ischemia/reperfusion injury after isogeneic kidney transplantation in rats: in vivo, preclinical, case–control, open-label study

Renal Replacement Therapy, 2023
Background Renal ischemia/reperfusion injury is an unavoidable event in transplantation in which free radical-mediated injury determines release of pro-inflammatory cytokines and activation of innate immunity.
Giacomo Cusumano, Edoardo Cola, Gionata Spagnoletti, Anna Severino, Simona Giubilato, Egidio Stigliano, Maria Emiliana Caristo, Gisella Vischini, Giovanna Liuzzo, Maria Paola Salerno, Filippo Crea, Jacopo Romagnoli   +11 more
doaj   +1 more source

The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation

Journal of Cardiothoracic Surgery, 2019
Background Graft function may be affected if the organ is exposed to hypoxia. We hypothesized that bronchiolitis obliterans (BO) after lung transplantation is associated with hypoxia-inducible factor-1α (HIF-1α). This study compares the expression of HIF-
Haichao Xu, Abudumailamu Abuduwufuer, Wang Lv, Zhenyu Zhou, Yunhai Yang, Chong Zhang, Jian Hu   +6 more
doaj   +1 more source

The glomerular filtration rate of isogeneically transplanted rat kidneys

Kidney International, 1982
The glomerular filtration rate (GFR) was determined in rats with an isogeneic kidney transplant and compared with that of unilaterally nephrectomized rats. Experiments were carried out in adult rats, 3 months of age, weighing approximately 300 g, as well as in juvenile rats, 6 to 8 weeks of age, weighing approximately 170 g.
Provoost, Abraham P., de Keijzer, Marinus H., Kort, Wil J., Wolff, Erik D., Molenaar, Jan C.   +4 more
openaire   +2 more sources

Intrauterine Transplantation of Isogenic Pancreatic Islets in Experimental Diabetic Rats.

Journal of Veterinary Medical Science, 1994
The effect of intrauterine transplantation (IU group) as a potential immunologically privileged site on the diabetic state of the recipient was compared with that of conventional intraperitoneal transplantation (IP group) using Fisher 344 rats. Islets were isolated from the pancreata of normal rats and transplanted into the uterus and peritoneal cavity
SAKONJU, Iwao, TAURA, Yasuho, NAKAICHI, Munekazu, NAKAMA, Sanenori, KAGABU, Satoshi   +4 more
openaire   +3 more sources

Transplante isogênico de ilhotas de Langerhans no fígado de ratos: metodologia para separação e purificação das ilhotas de Langerhans Isogenic islet transplantation on the rat liver: Method for isolation and purification of the rat islets

Arquivos de Gastroenterologia, 2000
A maior indicação do transplante de pâncreas ou de ilhotas de Langerhans é o diabetes mellitus do tipo I. O processo deve suprir as necessidades de insulina mantendo os níveis glicêmicos dentro da normalidade.
Eleazar CHAIB, Apostolos PAPALOIS, Ingrid G. M. BRONS, Roy Y. CALNE   +3 more
doaj   +1 more source

Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF‐α‐Smurf1‐Akt‐mTOR‐P70S6K pathway

Journal of Cellular and Molecular Medicine, Volume 23, Issue 8, Page 5390-5402, August 2019., 2019
Abstract Allograft interstitial fibrosis was characterized by massive extracellular matrix deposition caused by activated fibroblasts and myofibroblasts. Epithelial‐mesenchymal transition (EMT) is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis.
Jiajun Zhou, Hong Cheng, Zijie Wang, Hao Chen, Chuanjian Suo, Hengcheng Zhang, Jiayi Zhang, Yanhao Yang, Liang Geng, Ming Gu, Ruoyun Tan   +10 more
wiley   +1 more source

Effects of Iso and Xeno Fetal Liver Fragments Transplantation on Acute and Chronic Liver Failure in Rats

Cell Transplantation, 1994
Isogeneic (rat) and xenogeneic (swine) fetal liver fragments (FLF) transplantation into the omentum was performed for d-galactosamine (d-Gal)-induced acute and carbon tetrachloride (CCI 4 )-induced chronic hepatic failure in rats. The recipients that had
M. Hagihara, T. Shimura, K. Takebe, B. Munkhbat, K. Tsuji   +4 more
doaj   +1 more source

Renal Allograft Rejection: Noninvasive Ultrasound‐ and MRI‐Based Diagnostics

Contrast Media &Molecular Imaging, Volume 2019, Issue 1, 2019., 2019
To date, allogeneic kidney transplantation remains the best available therapeutic option for patients with end‐stage renal disease regarding overall survival and quality of life. Despite the advancements in immunosuppressive drugs and protocols, episodes of acute allograft rejection, a sterile inflammatory process, continue to endanger allograft ...
Ulrich Jehn, Katharina Schuette-Nuetgen, Dominik Kentrup, Verena Hoerr, Stefan Reuter, Sarah Ohrndorf   +5 more
wiley   +1 more source