Role of Hyperglycemia in Isogeneic Islet Transplantation: An Experimental Animal Study [PDF]
Experimental and Clinical Endocrinology and Diabetes, 2008 Study the role of hyperglycemia-induced beta cell loss on grafted islet destruction.Male inbred rats were made diabetic by streptozotocin administration and used as islet donors and/or isograft recipients to probe directly the role of hyperglycemia as an important determinant of transplanted islet fate, following exclusion of immune-related causes of ...
Maria Satra
exaly +6 more sources
Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats [PDF]
Journal of Diabetes Research, 2013 In this paper, we established a delayed wound healing model on diabetic rat to mimic the pathophysiology of clinical patients who suffered from diabetic foot ulcers.
Jiangbo Wan +4 more
doaj +4 more sources
Noninvasive quantification of granzyme B in cardiac allograft rejection using targeted ultrasound imaging [PDF]
Frontiers in Immunology, 2023 ObjectiveEndomyocardial biopsy is the gold standard method for the diagnosis of cardiac allograft rejection. However, it causes damage to the heart.
Yunjie Jin +14 more
doaj +4 more sources
THE INFLUENCE OF THE RECIPIENT UPON RENAL FUNCTION AFTER ISOGENEIC KIDNEY TRANSPLANTATION IN THE RAT
Transplantation, 1984 Little attention has been paid to the changes in renal function that occur after kidney transplantation when donor and recipient differ markedly in size. We studied this phenomenon after isogeneic kidney transplantation in rats of varying body weight (BW).
A P Provoost, E D Wolff, J C Molenaar
exaly +5 more sources
High-dose atorvastatin reduces oxidative stress of ischemia/reperfusion injury after isogeneic kidney transplantation in rats: in vivo, preclinical, case–control, open-label study [PDF]
Renal Replacement Therapy, 2023 Background Renal ischemia/reperfusion injury is an unavoidable event in transplantation in which free radical-mediated injury determines release of pro-inflammatory cytokines and activation of innate immunity.
Giacomo Cusumano +11 more
doaj +3 more sources
ISOGENEIC ISLET TRANSPLANTATION
Transplantation, 1991 81557
Peter R F Bell, Roger F L James
exaly +5 more sources
Molecular Medicine Reports, 2018 The present study investigated the effects of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in transplantation-associated arteriosclerosis by observing their expression in transplanted aortas in rats. Allogenic and isogenic abdominal aortic transplantations were performed and grafts were removed from the recipients
Si-Dong, Wei +5 more
semanticscholar +5 more sources
The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation
Journal of Cardiothoracic Surgery, 2019 Background Graft function may be affected if the organ is exposed to hypoxia. We hypothesized that bronchiolitis obliterans (BO) after lung transplantation is associated with hypoxia-inducible factor-1α (HIF-1α). This study compares the expression of HIF-
Haichao Xu +6 more
doaj +2 more sources
Nanotherapeutics in transplantation: How do we get to clinical implementation? [PDF]
Am J Transplant, 2022 Patients undergoing organ transplantation transition from one life‐altering issue (organ dysfunction) to a lifelong commitment—immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the long‐term and ...
Plumblee L +5 more
europepmc +2 more sources
Transplanting old organs promotes senescence in young recipients. [PDF]
Am J Transplant, 2023 In clinical organ transplantation, donor and recipient age may differ substantially. Old donor organs accumulate senescent cells that have the capacity to induce senescence in naïve cells.
Iske J +19 more
europepmc +2 more sources